[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332024-105":59,"doc-detail-332024-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","cd8-t-cell-based-cancer-immunotherapy-review-mechanisms-and-therapeutic-regimens","CD8 + T cell-based cancer immunotherapy - Review - Mechanisms and Therapeutic Regimens","","The immune system safeguards humans against both external and internal threats, with CD8+ T cells serving a crucial role in eliminating pathological dangers. Over recent decades, CD8+ T cell-based immunotherapies have shown encouraging results against difficult-to-treat conditions. In cancer, however, tumors evolve and can undermine CD8+ T cell formation and killing by recruiting immune escape accomplices. This review explains CD8+ T cell biology, maps tumor immune escape mechanisms, and evaluates multiple immunotherapy regimens, highlighting advantages, drawbacks, and future challenges for clinical translation.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cd8-t-cell-based-cancer-immunotherapy-review-mechanisms-and-therapeutic-regimens/332024/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cd8-t-cell-based-cancer-immunotherapy-review-mechanisms-and-therapeutic-regimens/332024.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What role do CD8+ T cells play in cancer immunity?","Question",{"text":113,"@type":114},"CD8+ T cells are the main effectors of acquired cellular immunity and are highly destructive against tumors when they encounter them.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do tumors interfere with CD8+ T cell function?",{"text":118,"@type":114},"Tumors can adopt immune escape strategies that disrupt immune surveillance, thereby disturbing effective CD8+ T cell functions and promoting uncontrolled growth.",{"name":120,"@type":111,"acceptedAnswer":121},"Which CD8+ T cell-based immunotherapies are discussed in the review?",{"text":122,"@type":114},"The review discusses regimens such as immune checkpoint blockers, neoantigen vaccines, CAR-T, and TCR-T, and also mentions approved autologous TIL-based therapy.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},332024,1790440324,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Chen et al. Journal of Translational Medicine (2024) 22:394  \n[https://doi.org/10.1186/s12967-024-05134-6](https://doi.org/10.1186/s12967-024-05134-6)  \nJournal of Translational Medicine  \nREVIEW Open Access  \nCD8 + T cell-based cancer immunotherapy  \nYanxia Chen 1†, Dingning Yu 1,2†, Hui Qian 1,3, Yinghong Shi 1,3* and Zhimin Tao 1,3,4*  \nAbstract  \nThe immune system in humans is a defense department against both exogenous and endogenous hazards, where CD8+ T cells play a crucial role in opposing pathological threats. Various immunotherapies based on CD8+ T cells have emerged in recent decades, showing their promising results in treating intractable diseases. However, in the fight against the constantly changing and evolving cancers, the formation and function of CD8+ T cells can be challenged by tumors that might train a group of accomplices to resist the T cell killing. As cancer therapy stepped into the era of immunotherapy, understanding the physiological role of CD8+ T cells, studying the machinery of tumor immune escape, and thereby formulating different therapeutic strategies become the imperative missions for clinical and translational researchers to fulfill. After brief basics of CD8+ T cell-based biology is covered, this review delineates the mechanisms of tumor immune escape and discusses different cancer immunotherapy regimens with their own advantages and setbacks, embracing challenges and perspectives in near future. Keywords CD8+ T cell, Cancer therapy, CAR-T, Checkpoint inhibitor, Solid tumor  \nIntroduction  \nThe basics of cancer immunotherapy is to initiate and optimize the key procedures in the innate or acquired immune system, including but not limited to, surveillance, identification, and elimination of tumors [1]. The ultimate executors of acquired cellular immunity, i.e., CD8+ T cells, are exceptionally destructive when encountering tumors [2]. The advent of novel cancer treatments,  \n†Yanxia Chen and Dingning Yu contributed equally to this work.  \n*Correspondence: Yinghong Shi [shiwuyisunny@163.com](shiwuyisunny@163.com)[ ](shiwuyisunny@163.com)Zhimin Tao [jsutao@ujs.edu.cn](jsutao@ujs.edu.cn)  \n1Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China  \n2Department of Laboratory Medicine, Shaoxing People’s Hospital, Shaoxing, Zhejiang 312000, China  \n3Zhenjiang Key Laboratory of High Technology Research on Exosomes Foundation and Transformation Application, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China  \n4Department of Emergency Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China  \nsuch as immune checkpoint blockers, neoantigen vaccines, chimeric antigen receptor T (CAR-T) cell therapy and T-cell receptor T (TCR-T) cell therapy, points to that CD8+ T cell-based immunotherapy has gained dramatic breakthroughs. Recently, autologous cell therapy using tumor-infiltrating lymphocytes (TILs) has been approved by the United States (US) Food and Drug Administration (FDA) to treat patients with unresectable or metastatic melanoma, further bolstering the already rapid development of novel CD8+ T cell-involved therapy [3].  \nUnder normal circumstances, the immune system monitors the aberrant activities in the body and identifies and removes the suspicious components (e.g., tumor cells), thereby preventing tumor initiation. However, in patients suffering from cancers, the fulfillment of immune surveillance can go awry. A variety of immune escape strategies might be adopted by tumors to counteract the host’s monitoring, thus leading to uncontrolled tumor growth [4, 5]. Under these circumstances, the effective functions of CD8+ T cells can be remarkably disturbed. Therefore, exploration of constantly changing immune escape mechanisms and development of  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons","cbCaidjRWvUcbG2t","https://ap.wps.com/l/cbCaidjRWvUcbG2t","pdf",3715496,17,"English","# Introduction\n## Basics of cancer immunotherapy and CD8+ T cells\n## CD8+ T cell-based therapeutic breakthroughs","[{\"question\":\"What role do CD8+ T cells play in cancer immunity?\",\"answer\":\"CD8+ T cells are the main effectors of acquired cellular immunity and are highly destructive against tumors when they encounter them.\"},{\"question\":\"How do tumors interfere with CD8+ T cell function?\",\"answer\":\"Tumors can adopt immune escape strategies that disrupt immune surveillance, thereby disturbing effective CD8+ T cell functions and promoting uncontrolled growth.\"},{\"question\":\"Which CD8+ T cell-based immunotherapies are discussed in the review?\",\"answer\":\"The review discusses regimens such as immune checkpoint blockers, neoantigen vaccines, CAR-T, and TCR-T, and also mentions approved autologous TIL-based therapy.\"}]","CD8 + T cell-based cancer immunotherapy - Review - Mechanisms and Therapeutic Regimens | PDF",1789996359,43]