[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332348-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-332348-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","cd58-defines-regulatory-macrophages-within-the-tumor-microenvironment-article","CD58 defines regulatory macrophages within the tumor microenvironment - Article","","CD58 is implicated in immune suppression and cancer stemness, yet predictive biomarkers for immunotherapy response remain limited. This study evaluates CD58’s immune predictive significance in glioma patients by linking CD58 expression with clinicopathologic features and tumorigenic potential. CD58high cells accelerate tumor formation in vivo and induce macrophage polarization via CXCL5 secretion, enhancing PD-L1 regulation through IL-6 in vitro. CD58-based evaluation supports identifying patients likely to benefit from immunotherapy.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/cd58-defines-regulatory-macrophages-within-the-tumor-microenvironment-article/332348/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/cd58-defines-regulatory-macrophages-within-the-tumor-microenvironment-article/332348.png","ImageObject",300,407,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main focus regarding CD58 in this work?","Question",{"text":63,"@type":64},"The work assesses the immune predictive significance of CD58 in glioma patients, linking its expression to patient outcomes and tumor behavior.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do CD58high cells affect tumor formation?",{"text":68,"@type":64},"CD58high cells show accelerated tumor formation in vivo compared with CD58low cells.",{"name":70,"@type":61,"acceptedAnswer":71},"What mechanism connects CD58high glioma to macrophage regulation?",{"text":72,"@type":64},"CD58high glioma induces macrophage polarization through CXCL5 secretion, with M2 macrophages regulating PD-L1 expression via IL-6 production in vitro.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332348,1790185409,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","communications biology Article  \n[https://doi.org/10.1038/s42003-024-06712-6](https://doi.org/10.1038/s42003-024-06712-6)  \nCD58 defines regulatory macrophages within the tumor microenvironment  \n Check for updates  \nBo Wu1,4, Xiaoni Zhan2,4 & Meixi Jiang 3   \nCD58has been implicated in immune suppression andisassociated with stemness in various types of cancer. Nonetheless, efficient biomarkers for assessing cancer patient response to immunotherapy are lacking. The present work focused on assessing the immune predictive significance of CD58 for patients with glioma. The expression of CD58 correlates with the clinicopathologic characteristics of patients with glioma, suggesting CD58high cells to signify glioma with tumorigenic potential. The CD58high cells displayed accelerated tumor formation compared to CD58low cells in vivo. Taken together, CD58 could potentially serve as a marker for glioma. CD58high glioma induces macrophage polarization through CXCL5 secretion, where M2 macrophages regulate PD-L1 expression within CD58high glioma via IL-6 production in vitro. Moreover, it was found that combination treatment with CD58 significantly increased the volume of tumors in the xenograft specimens. Evaluating CD58 expression represents a promising approach for identifying patients who can benefit from immunotherapy.  \nImmune checkpoint blockades-based immunotherapy represents the candidate treatment for advanced solid and liquid tumor patients1. Immune structure, with the feature of typical infiltrating immune cell components, density and functional status in tumor microenvironment (TME), significantly influences clinical outcomes2,3. TME-targeting immunotherapy has emerged as a cancer treatment. However, because of the considerable TME heterogeneity, monoclonal anti-programmed cell death protein 1 (PD-1) antibody is associated with a poor response rate4. Therefore, identifying new immunoregulatory factors for enhancing anti-tumor response is crucial. Macrophages account for innate immune cells with the highest abundance within TME, which demonstrate potent tumor-promoting and immunosuppressive activities in numerous cancers and are important for establishing efficient anticancer immunity5. Inline with environmental cues, tumor-associated macrophages demonstrate various activation statuses to exert typical effects, which are simply categorized into classically activated6–8. Nonetheless, cancer cells are recently suggested to increase anti-phagocytic marker expression, evading macrophage phagocytosis9. Therefore, a comprehensive exploration of the significance of macrophages in cancer is essential.  \nCD58, called LFA-3 as well, is an immune adhesion molecule and a surface glycoprotein with a high glycosylation level(40–70 kDa), besides, its expression can be widely detected in nonhematopoietic and hematopoietic cells10, 11. CD58 expressed on the cell surface enhances the effector–target adhesion in the case of antigen-specific recognition12. It also provides an  \nefficient second signal to activate T cells, as a result, it can optimize and replenish theTCR/CD3pathway-regulated proliferative response13, 14. CD58 expression is regulated by cytokines in a cell-dependent manner15–17. CD58 expression remained unchanged after bronchial epithelial cells were stimulated by TNF-α and IFN-γ18. CD58 is the risk factor, and there is nodefinite report regarding its relation with tumor-associated macrophages. Such observations provide more information regarding the effect of CD58 on cancer and offer the potential predictive system for evaluating the prognosis of cancer patients.  \nResults  \nCD58 expression in pan-cancer  \nFor analyzing CD58 levels in healthy and tumor tissues, the UCSC xenaShiny online approach was used. CD58 expression in pan-cancer was analyzed, which suggested that CD58 expression was significantly different in tumors compared with matched non-carcinoma tissues (Fig. 1a). Subsequently, patients from the cohort of 33 cancers were classified","cbCaiaHXGWwfOOVz","https://ap.wps.com/l/cbCaiaHXGWwfOOVz","pdf",3855412,13,"English","# CD58 expression in pan-cancer\n## Prognostic impact across cancer cohorts\n# CD58high glioma cells harbor stemness properties\n## Gene set enrichment analysis","[{\"question\":\"What is the main focus regarding CD58 in this work?\",\"answer\":\"The work assesses the immune predictive significance of CD58 in glioma patients, linking its expression to patient outcomes and tumor behavior.\"},{\"question\":\"How do CD58high cells affect tumor formation?\",\"answer\":\"CD58high cells show accelerated tumor formation in vivo compared with CD58low cells.\"},{\"question\":\"What mechanism connects CD58high glioma to macrophage regulation?\",\"answer\":\"CD58high glioma induces macrophage polarization through CXCL5 secretion, with M2 macrophages regulating PD-L1 expression via IL-6 production in vitro.\"}]","CD58 defines regulatory macrophages within the tumor microenvironment - Article | PDF",1789997813,33]