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Aim: Identify tumor-derived exosomes that distinguish immune-hot versus immune-cold tumors and reflect immunotherapy responses. Methods: Transcriptomic and single-cell RNA-seq datasets were used to map CD47 expression and immuno-correlations in ovarian and epithelial cancers, with a pan-gynecological cohort for validation. Results: CD47 defined a tumor exosomal signature without clinicopathological transcriptional differences, correlated with immune signaling activation, immune-cell enrichment, immune-hot/cold discrimination, and higher immunotherapy sensitivity. TMA showed CD47 upregulation and association with CD8 levels. Conclusion: CD47 marks inflammatory TME, immune-hot tumors, and immunotherapy responsiveness.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cd47-is-a-tumor-cell-derived-exosomal-signature-and-regulates-tumor-immune-microenvironment-and-immunotherapy-responses-article-abstract/374122/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cd47-is-a-tumor-cell-derived-exosomal-signature-and-regulates-tumor-immune-microenvironment-and-immunotherapy-responses-article-abstract/374122.png","ImageObject",300,407,{"name":92,"@type":93},"Eliana","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study’s main goal regarding CD47 and exosomes?","Question",{"text":113,"@type":114},"To identify tumor-derived exosomal (TEX) features, especially CD47, that can distinguish immune-hot versus immune-cold tumors and predict immunotherapy responses.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were transcriptomic and single-cell RNA-seq datasets used?",{"text":118,"@type":114},"The study downloaded transcriptomic and scRNA-seq datasets to analyze CD47 expression patterns and its immunological correlations across ovarian cancer and multiple epithelial cell carcinomas.",{"name":120,"@type":111,"acceptedAnswer":121},"What relationship did the study find between CD47 expression and immunotherapy response?",{"text":122,"@type":114},"In immunotherapy cohorts, patients with a CD47-high phenotype were more sensitive to immunotherapy and tended to achieve remission after treatment, alongside evidence of CD47 upregulation and CD8 association.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},374122,1790248913,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","Translational Oncology 53 (2025) 102291  \nContents lists available at ScienceDirect Translational Oncology  \njournal [homepage:](homepage: www.elsevier.com/locate/tranon)[ www.elsevier.com/locate/tranon](homepage: www.elsevier.com/locate/tranon)  \n| CD47 is a tumor cell-derived exosomal signature and regulates tumor immune microenvironment and immunotherapy responses\u003Cbr>Yifei Luan a,1 , Yinghui Zhang b,1, Shangjin Lib,1, Caiyun Gaoc, Xinyi Ying d, Shaojie Zhao b,2,*, Bing Zhang b,2,*\u003Cbr>a School of Innovation and Entrepreneurship, Hangzhou Medical College, Hangzhou 310053, PR China\u003Cbr>b Wuxi Maternal and Child Health Care Hospital, The Affiliated Women’s Hospital of Jiangnan University, Wuxi 214002, PR China c Market Supervision and Law Enforcement Guarantee Service Center of Xihu District, Hangzhou 310013, PR China\u003Cbr>d Department of Clinical Medicine, Hangzhou Medical College, Hangzhou 310053, PR China |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Key words:\u003Cbr>Ovarian cancer Exosome\u003Cbr>CD47 Immunotherapy Gynecological cancer |  | Background: The pathogenesis of ovarian cancer (OvCa) involves a complex interplay of genetic, environmental, and hormonal factors. With the in-depth exploration of tumor ecosystem, exosomes can mediate the immunological status of tumor microenvironment (TME). Therefore, we aimed to recognize the tumor-derived exosomes (TEXs) which can distinguish the immune-hot and cold tumors and reflect the immunotherapeutic responses. Methods: A large set of transcriptomic and single-cell RNA-sequencing (scRNA-seq) datasets were downloaded and used to analyze the expression pattern of CD47 and its immuno-correlations in OvCa and multiple epithelial cell carcinomas such as breast cancers. In addition, a pan-gynecological cancer cohort was used to validate the correlation between CD47 and the inflamed TME.\u003Cbr>Results: In the current study, we found that CD47 was a TEX signature and had no transcriptional differences among patients with different clinicopathological features. Moreover, CD47 expression was positively correlated with the activation of immunological signaling pathways and enrichment of immune cell subpopulations in OvCa. Furthermore, in breast cancer and gynecological cancers, CD47, specially expressed in tumor cells, also showed favorable ability to distinguish the immune-hot and cold carcinomas. Moreover, in immunotherapy cohorts of breast cancer and other epithelial cell carcinomas, patients with CD47-high phenotype were more sensitive to immunotherapy and tended to achieve remission after treatment. Results from the TMA showed that CD47 was upregulated in tumor tissues and positively correlated with CD8 level.\u003Cbr>Conclusion: In conclusion, CD47 is associated with an inflammatory TME, immune-hot tumors, and sensitivity of immunotherapy, highlighting the values of CD47 in identifying immunological traits and an immunotherapeutic response. |\n\nIntroduction  \nOvarian cancer (OvCa) is one of the most common malignant tumors, with the worst morbidity and poor prognosis of any gynecological cancers worldwide [1,2]. Despite the incidence of OvCa is third after cervix and uterine among gynecologic cancers, it is responsible for more deaths, which accounted for 313,959 cases and 207,252 deaths annually [3,4]. The low survival rates of OvCa have been the focus of  \ninvestigation in recent decades [5]. Even though patients diagnosed atan early stage have a five-year relative survival rate of >90 %, over two-thirds are diagnosed at advanced stages and have poor clinical outcomes despite the application of the innovative molecular targeted therapy [2].  \nDuring the past decade, accumulating researchers have focused on the application of immunotherapy on multiple solid carcinomas, which has revolutionized the management of multiple solid carcinomas [6,7].  \n* Correspondence authors at: Department of Gynecology, Wuxi Maternal and Child Health Care Hospital, The Affiliated Women’s Ho","cbCaimnxT3DNfWoY","https://ap.wps.com/l/cbCaimnxT3DNfWoY","pdf",17073170,"English","# Abstract\n# Introduction","[{\"question\":\"What was the study’s main goal regarding CD47 and exosomes?\",\"answer\":\"To identify tumor-derived exosomal (TEX) features, especially CD47, that can distinguish immune-hot versus immune-cold tumors and predict immunotherapy responses.\"},{\"question\":\"How were transcriptomic and single-cell RNA-seq datasets used?\",\"answer\":\"The study downloaded transcriptomic and scRNA-seq datasets to analyze CD47 expression patterns and its immunological correlations across ovarian cancer and multiple epithelial cell carcinomas.\"},{\"question\":\"What relationship did the study find between CD47 expression and immunotherapy response?\",\"answer\":\"In immunotherapy cohorts, patients with a CD47-high phenotype were more sensitive to immunotherapy and tended to achieve remission after treatment, alongside evidence of CD47 upregulation and CD8 association.\"}]","CD47 is a tumor cell-derived exosomal signature and regulates tumor immune microenvironment and immunotherapy responses - Article Abstract | PDF",1790201162,35]