[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-383731-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-383731-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","causes-of-death-among-patients-with-cutaneous-melanoma-a-us-population-based-study","Causes of death among patients with cutaneous melanoma - a US population-based study","","Research on mortality outcomes and non-cancer-related causes of death in patients with cutaneous melanoma (CM) remains limited. This US population-based study used the SEER database to analyze 224,624 malignant CM patients diagnosed between 2000 and 2019. Deaths totaled 60,110 (26.8%); proportions rose with stage, reaching 80% in distant melanoma. Non-cancer causes were most common in localized disease, while cardiovascular and cerebrovascular conditions dominated. Compared with the general population, localized CM showed no increased non-cancer mortality risk, whereas regional and distant cohorts did.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/causes-of-death-among-patients-with-cutaneous-melanoma-a-us-population-based-study/383731/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/causes-of-death-among-patients-with-cutaneous-melanoma-a-us-population-based-study/383731.png","ImageObject",300,407,{"name":42,"@type":43},"\tJames","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-27","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":30},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What question does the study address about cutaneous melanoma outcomes?","Question",{"text":62,"@type":63},"The study evaluates the prevalence of non-cancer-related deaths after a cutaneous melanoma diagnosis and compares mortality risk across melanoma stages.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"Which data source and time period were used to build the patient cohort?",{"text":67,"@type":63},"The cohort includes 224,624 patients diagnosed with malignant cutaneous melanoma in the United States between 2000 and 2019, extracted from the SEER database.",{"name":69,"@type":60,"acceptedAnswer":70},"How did non-cancer deaths vary by melanoma stage?",{"text":71,"@type":63},"The share of deaths increased with disease stage, reaching 80% in distant melanoma. For localized melanoma, most fatalities (60.5%) were from non-cancer causes.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},383731,1790457718,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":30,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},2336474466412,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nCauses of death among patients with cutaneous melanoma: a US population‑based study  \nMohammed Ahmed Sadeq1,3, Mohamed HadyAshry2,3,  \nReem Mohammed Farouk Ghorab1 & Abdelrahman Yousry Afify2*  \nResearch on mortality outcomes and non‑cancer‑related causes of death in patients with cutaneous melanoma (CM) remains limited. This study aimed to identify the prevalence of non‑cancer‑related deaths following CM diagnosis. The data of 224,624 patients diagnosed with malignant CM in the United States between 2000 and 2019 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We stratified our cohort based on their melanoma stage at diagnosis and further calculated standardized mortality ratios (SMRs) for each cause of death, comparing their relative risk to that of the general US population. The total number of fatalities among melanoma patients was 60,110, representing 26.8% of the total cases. The percentage of deaths is directly proportional to the disease stage, reaching 80% in distant melanoma. The highest fatalities among the localized melanoma group (25,332; 60.5%) occurred from non‑cancer causes, followed by melanoma‑attributable deaths (10,817; 25.8%). Conversely, melanoma is the leading cause of death in regional and distant melanoma cohorts. Cardiovascular and cerebrovascular diseases were the most prevalent non‑cancer causes of death among the three disease‑stage cohorts. Compared to the general population, we did not observe an increased risk of death dueto non‑cancer causes in the localized CM cohort, while patients diagnosed with regional and distant CMs had a statistically significant higher risk of death from all the reported major causes of death.  \nAbbreviations  \nCM Cutaneous melanoma  \nSEER Surveillance, epidemiology, and end results SMR Standardized mortality ratio  \nICD-10 International classification of disease-tenth revision O/E Observed-to-expected ratio  \nMelanoma is an aggressive type of cancer that usually originates in the skin, typically starting out as a mole following cell DNA damage related to ultraviolet (UV) radiation exposure from the sun or tan beds, with an increased risk in old, light-skinned, positive family history, and immunosuppressed individuals. It often arises from cutaneous epidermal melanocytes; however, it can occur in any melanocyte-containing tissue, such asthe genitourinary and uveal tracts1. Although melanoma only makes for less than 10% of skin cancer cases2, it remains the deadliest type owing to its aggressiveness and high mortality rate. In addition, the incidence of melanoma is increasing at an alarming rate faster than any other solid tumor, becoming the fifth most common cancer in the United States1.  \nThe pathophysiology of melanoma involves the uncontrolled growth and spread of abnormal melanocytes. These cells can arise from existing moles or develop in previously healthy skin. Melanoma can be classified into four stages, with stage I being the earliest and stage IV the most advanced. In the early stages, cancer is confined to the outermost layer of the skin, but as it progresses, it can invade deeper layers of the skin and spread to other parts of the body via the lymphatic system or bloodstream3.  \nThe stage of the disease, the site of growth, and the patient’s general health all influence melanoma treatment. The main therapy for early-stage melanoma is surgical excision, which includes the removal of the cancerous lesion as well as a margin of nearby healthy tissue. In some instances, lymph nodes may be removed to avoid  \n1Faculty of Medicine, Misr University for Science and Technology, 6th of October, Giza, Egypt. 2School of Medicine, New Giza University (NGU), Giza, Egypt. 3These authors contributed equally: Mohammed Ahmed Sadeq and Mohamed HadyAshry.*[email: aafify@ngu.edu.eg](email: aafify@ngu.edu.eg)  \n[www. nature.com/scientificreports/](www. nature.com/","cbCaijux2IDHPOL2","https://ap.wps.com/l/cbCaijux2IDHPOL2","pdf",1060519,11,"English","# Methods\n## Data source and cohort selection\n## Mortality analysis approach\n# Results\n## Overall fatalities and stage distribution\n## Non-cancer causes by stage\n## Comparison with general population","[{\"question\":\"What question does the study address about cutaneous melanoma outcomes?\",\"answer\":\"The study evaluates the prevalence of non-cancer-related deaths after a cutaneous melanoma diagnosis and compares mortality risk across melanoma stages.\"},{\"question\":\"Which data source and time period were used to build the patient cohort?\",\"answer\":\"The cohort includes 224,624 patients diagnosed with malignant cutaneous melanoma in the United States between 2000 and 2019, extracted from the SEER database.\"},{\"question\":\"How did non-cancer deaths vary by melanoma stage?\",\"answer\":\"The share of deaths increased with disease stage, reaching 80% in distant melanoma. For localized melanoma, most fatalities (60.5%) were from non-cancer causes.\"}]","Causes of death among patients with cutaneous melanoma - a US population-based study | PDF",1790258938,28]