[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332273-105":3,"detail-sidebar-cat-0-en-105":85,"doc-detail-332273-en":135},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":78,"head_meta":80,"extra_data":82,"updated_unix":84},105,"en","causality-between-six-psychiatric-disorders-and-digestive-tract-cancers-risk-a-two-sample-mendelian-randomization-study","Causality between six psychiatric disorders and digestive tract cancers risk - a two-sample Mendelian randomization study","","Associations between psychiatric disorders and digestive tract cancers have been proposed, yet the causal relationship remains unclear. This study applies two-sample Mendelian randomization to test genetic links between six psychiatric disorders—schizophrenia, bipolar disorder, major depressive disorder, attention deficit hyperactivity disorder, autism spectrum disorder, and panic disorder—and risk of esophagus cancer, gastric cancer, and colorectal cancer using genome-wide association data. Inverse-variance weighted, weighted median, and MR-Egger analyses found no causal effect for esophagus or gastric cancers, and no increased colorectal cancer risk overall. Panic disorder showed a lower colorectal cancer risk (OR=0.79, 95% CI 0.66–0.93, P=0.01).",{"@graph":14,"@context":77},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/causality-between-six-psychiatric-disorders-and-digestive-tract-cancers-risk-a-two-sample-mendelian-randomization-study/332273/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/causality-between-six-psychiatric-disorders-and-digestive-tract-cancers-risk-a-two-sample-mendelian-randomization-study/332273.png","ImageObject",300,407,{"name":42,"@type":43},"Noah","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69,73],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main goal of this study?","Question",{"text":63,"@type":64},"To evaluate whether six psychiatric disorders have a causal genetic link with the risk of esophagus, gastric, and colorectal cancers using two-sample Mendelian randomization.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which psychiatric disorders and digestive tract cancers were analyzed?",{"text":68,"@type":64},"Psychiatric disorders included schizophrenia, bipolar disorder, major depressive disorder, ADHD, autism spectrum disorder, and panic disorder. Digestive tract cancers included esophagus cancer, gastric cancer, and colorectal cancer.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the study find about causal effects for esophagus and gastric cancers?",{"text":72,"@type":64},"No causal link was identified between psychiatric disorders and the risk of esophagus cancer or gastric cancer.",{"name":74,"@type":61,"acceptedAnswer":75},"How did panic disorder relate to colorectal cancer risk?",{"text":76,"@type":64},"Panic disorder was associated with a lower colorectal cancer risk (OR = 0.79, 95% CI 0.66–0.93, P = 0.01).","https://schema.org",{"og:url":32,"og:type":79,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":81,"canonical":32},"index,follow",{"doc_id":83,"site_id":7},332273,1790168454,{"code":4,"msg":86,"data":87},"success",[88,92,96,100,105,110,115,119,124,127,131],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Exam",70,"exam",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},5,"Comic",60,"comic",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},6,"Technology",50,"technology",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},7,"Healthcare",40,"healthcare",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":117,"slug":118},8,30,"research-report",{"id":120,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":122,"slug":123},9,"Religion & Spirituality",20,"religion-spirituality",{"id":122,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":122,"slug":126},"World Cup","world-cup",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":128,"slug":130},10,"Lifestyle","lifestyle",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":133,"show_sort_weight":101,"slug":134},19,"General","general",{"code":4,"msg":86,"data":136},{"doc_id":83,"user_id":137,"nickname":42,"user_avatar":138,"doc_module":4,"category_id":116,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":139,"file_id":140,"file_url":141,"file_type":142,"file_size":143,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":144,"language":145,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":146,"faqs":147,"seo_title":148,"seo_description":12,"update_tm":149,"read_time":150,"preview_page_count":4},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nCausality between six psychiatric disorders and digestive tract cancers risk: a two‑sample Mendelian randomization study  \nQi Fu1, Linghui Li2, Niyang Zhuoma3, Rui Ma1, Zhixi Zhao3, Zhaxi Quzuo3, Zhen Wang3, Deji Yangzong3 & Ji Di1*  \nAssociations between psychiatric disorders and digestive tract cancers have been proposed. However, the causal link between these factors remains unclear. This study pioneers Mendelian randomization (MR) analysis to explore the genetic link between psychiatric disorders and digestive tract cancers risk. We analysed data on six psychiatric disorders [schizophrenia, bipolar disorder, major depressive disorder (MDD), attention deficit hyperactivity disorder, autism spectrum disorder, and panic disorder (PD)] and digestive tract cancers [esophagus cancer (EC), gastric cancer (GC), and colorectal cancer (CRC)] from genome‑wide association studies databases. Using instrumental variables identified from significant single nucleotide polymorphism associations, we employed the inverse variance weighted (IVW) method alongside the weighted median (WM) method and MR‑Egger regression. The results revealed no causal link between psychiatric disorders and the risk of EC or GC. Psychiatric disorders were not identified as risk factors for CRC. Notably, PD demonstrated a lower CRC risk (OR = 0.79, 95% CI 0.66–0.93, P = 0.01). This MR analysis underscores the lack of a causal association between psychiatric disorders and digestive tract cancers risk while suggesting a potential protective effect of PD against CRC.  \nKeywords Colorectal cancer, Esophagus cancer, Gastric cancer, Mendelian randomization, Psychiatric disorders  \nDigestive tract cancers predominantly encompass esophagus cancer (EC), gastric cancer (GC), and colorectal cancer (CRC) and are collectively characterised by elevated morbidity and mortality rates1. EC is the eighth most prevalent malignancy globally and the sixth leading cause of cancer-related mortality. The number of deaths from esophagus cancer is 500,000 each year2,3. The five-year survival rate for EC shows a notable decrease, registering merely 20% in the United States in 2023 and 40.1% in China in 20181,4. Sex, race, smoking, alcohol consumption, dietary habits, and nutritional status are recognized as risk factors for EC5. Epidemiological studies in 2022 disclosed GC as the fifth most common cancer globally, with an annual incidence surpassing 1.1 million6. Concurrently, GC has a high mortality rate, positioning it as the fourth leading cause of cancer-associated deaths7. According to statistical data, GC caused 800,000 deaths worldwide in 20208. Age, the presence of Helicobacter pylori, and reduced consumption of fruits and vegetables have been identified as risk factors for the development of GC9. CRC has a high incidence rate. Global cancer data from 2018 showed that 10% of all cancers diagnosed each year were CRC10. It is the second most prevalent cancer in men and the third most common in women. The overall number of individuals with CRC is increasing, with a projected 2.5 million new cases anticipated by the year 203511. Risk factors associated with CRC include sex, age, genetic predisposition, and inflammatory processes. Although numerous risk factors associated with digestive tract cancers have been validated, a multitude of potential risk factors, including psychiatric disorders, remain unexplored. Investigating the causal connections between these unidentified risk factors and digestive tract cancers holds clinical promise and offers valuable insights for the prevention and treatment of such malignancies.  \nThe term ‘psychiatric disorder’ describes conditions marked by deviations in perception, behaviour, and cognition. Psychiatric disorders often lead to suicidal behaviour, which is one of the most important public health  \n1Qinghai University Affiliated Hospital (The Clinical Medical School), Q","cbCailVKEVhDxPaj","https://ap.wps.com/l/cbCailVKEVhDxPaj","pdf",7201988,15,"English","# Background\n## Digestive tract cancers and risk factors\n## Psychiatric disorders and related mechanisms\n# Mendelian randomization study\n## Genetic instruments and GWAS datasets\n## Statistical methods (IVW, weighted median, MR-Egger)\n# Results\n## Esophagus cancer\n## Gastric cancer\n## Colorectal cancer and panic disorder finding","[{\"question\":\"What is the main goal of this study?\",\"answer\":\"To evaluate whether six psychiatric disorders have a causal genetic link with the risk of esophagus, gastric, and colorectal cancers using two-sample Mendelian randomization.\"},{\"question\":\"Which psychiatric disorders and digestive tract cancers were analyzed?\",\"answer\":\"Psychiatric disorders included schizophrenia, bipolar disorder, major depressive disorder, ADHD, autism spectrum disorder, and panic disorder. Digestive tract cancers included esophagus cancer, gastric cancer, and colorectal cancer.\"},{\"question\":\"What did the study find about causal effects for esophagus and gastric cancers?\",\"answer\":\"No causal link was identified between psychiatric disorders and the risk of esophagus cancer or gastric cancer.\"},{\"question\":\"How did panic disorder relate to colorectal cancer risk?\",\"answer\":\"Panic disorder was associated with a lower colorectal cancer risk (OR = 0.79, 95% CI 0.66–0.93, P = 0.01).\"}]","Causality between six psychiatric disorders and digestive tract cancers risk - a two-sample Mendelian randomization study | PDF",1789997617,38]