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This case report describes a 61-year-old woman with malignant thymic tumor invasion of the SVC who developed postoperative SVCS due to graft occlusion. Emergency endovascular therapy used 8F guiding catheter-directed thrombectomy followed by sequential balloon dilation and Bard venous stent placement, rapidly relieving stenosis and symptoms. Anticoagulation was continued with no thrombosis at August 2024 follow-up. The authors conclude the multimodal approach is feasible, safe, and effective, but patients require close monitoring and further studies are needed.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/catheter-directed-thrombectomy-combined-with-angioplasty-and-stent-implantation-for-superior-vena-cava-syndrome-a-case-report/448410/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/catheter-directed-thrombectomy-combined-with-angioplasty-and-stent-implantation-for-superior-vena-cava-syndrome-a-case-report/448410.png","ImageObject",300,407,{"name":92,"@type":93},"Mia  ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What condition does the case report focus on and what usually causes it after SVC reconstruction?","Question",{"text":113,"@type":114},"The report focuses on superior vena cava (SVC) syndrome (SVCS). Thrombus formation within the vascular graft is described as the most common cause after SVC reconstruction using e-PTFE grafts.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What multimodal endovascular treatment was used in the emergency setting?",{"text":118,"@type":114},"The emergency protocol combined 8F guiding catheter-directed thrombectomy, sequential balloon dilation, and Bard venous stent implantation to resolve the occlusion and stenosis.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the outcomes and follow-up results after treatment?",{"text":122,"@type":114},"The intervention rapidly relieved symptoms and resolved stenosis. The patient received anticoagulants and had no thrombosis at follow-up in August 2024.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},448410,1790779562,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46,"preview_page_count":4},687207024478,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Catheter-directed thrombectomy combined with angioplasty and stent implantation for superior vena cava syndrome: a case report  \nHao Wang, Zi-Yi Liu, Chang-Yuan Liu, Guang-Sheng Zhao, Shun-Xiong Tang, Jun-Jie Qu, Fang Xu, Jun Zhou  \nDepartment of Interventional Therapy, Affiliated Zhongshan Hospital of Dalian University, Dalian, China  \nContributions: (I) Conception and design: H Wang, ZY Liu; (II) Administrative support: J Zhou; (III) Provision of study materials or patients: HWang; (IV) Collection and assembly of data: CY Liu, JJ Qu, F Xu; (V) Data analysis and interpretation: ZY Liu, CY Liu; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.  \nCorrespondence to: Jun Zhou, MS. Department of Interventional Therapy, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian 116001, China. Email: [18698629436@163.com](18698629436@163.com).  \nBackground: Superior vena cava (SVC) syndrome (SVCS) caused by thrombosis in artificial vascular grafts is characterized by high morbidity and mortality, with endovascular treatment being the primary therapeutic approach. In this case report, we present a safe multimodal endovascular treatment protocol that can rapidly alleviate acute SVCS symptoms, combining targeted thrombectomy via a guiding catheter with balloon dilation and Bard venous stent placement. Such combined endovascular therapies remain relatively  \nuncommon in clinical reports.  \nCase Description: A 61-year-old female with a 10-year history of mediastinal nodules was admitted to hospital for recurrent dizziness. Via computed tomography (CT), she was diagnosed with a malignant thymic tumor invading the SVC and subsequently underwent sternotomy via a video-assisted thoracoscopic approach for tumor resection and SVC reconstruction with an 8-mm expanded polytetrafluoroethylene (e-PTFE) graft. Postoperatively, she developed SVCS (upper extremity/chest wall swelling, cyanosis) due to graft occlusion. Emergency treatment included 8F guiding catheter thrombectomy, sequential balloon dilatation, and Bard venous stenting, which resolved the stenosis. She received anticoagulants (lowmolecular-weight heparin and subsequent rivaroxaban) and had no thrombosis at follow-up in August 2024.  \nConclusions: The combination of guiding catheter thrombectomy, balloon dilatation, and Bard stent implantation is feasible, safe, and effective for e-PTFE graft-associated SVCS, relieving symptoms quickly and avoiding reoperation. This approach can benefit patients unsuited to surgery, but they should be monitored closely for adverse hemodynamic events after stenting. Further studies are needed to validate the  \nefficacy of this method.  \nKeywords: Superior vena cava syndrome (SVCS); angioplasty; stent implantation; expanded polytetrafluoroethylene  \ngraft (e-PTFE graft); case report  \nSubmitted Nov 11, 2025. Accepted for publication Dec 10, 2025. Published online Dec 24, 2025.  \ndoi: 10.21037/tcr-2025-aw-2492  \nView this article at: [https://dx.doi.org/10.21037/tcr-2025-aw-2492](https://dx.doi.org/10.21037/tcr-2025-aw-2492)  \nIntroduction  \nSuperior vena cava (SVC) syndrome (SVCS) is a wellrecognized clinical entity associated with significant morbidity and mortality. Thrombus formation within the vascular graft is considered the most common cause of postoperative SVC syndrome in patients undergoing SVC  \nreconstruction with expanded polytetrafluoroethylene (e-PTFE) . Here, we present a case of a female patient who developed SVC syndrome following artificial vascular graft implantation after resection of a malignant thymic tumor. Without removal of the graft, endovascular intervention—consisting of guiding catheter-directed thrombectomy  \n© AME Publishing Company. Transl Cancer Res 2025;14(12):9091-9098 | [https://dx.doi.org/10.21037/tcr-2025-aw-2492](https://dx.doi.org/10.21037/tcr-2025-aw-2492)  \n9092 Wang et al. Multimodal endoluminal interventional therapy for SVCS  \nFigure 1 The patient unde","cbCaipRPSo0JMdwL","https://ap.wps.com/l/cbCaipRPSo0JMdwL","pdf",434877,"English","# Introduction\n# Case Description\n# Conclusions\n# Highlight Box\n## Key findings\n## What is known and what is new?\n## What is the implication, and what should change now?\n# Case presentation","[{\"question\":\"What condition does the case report focus on and what usually causes it after SVC reconstruction?\",\"answer\":\"The report focuses on superior vena cava (SVC) syndrome (SVCS). Thrombus formation within the vascular graft is described as the most common cause after SVC reconstruction using e-PTFE grafts.\"},{\"question\":\"What multimodal endovascular treatment was used in the emergency setting?\",\"answer\":\"The emergency protocol combined 8F guiding catheter-directed thrombectomy, sequential balloon dilation, and Bard venous stent implantation to resolve the occlusion and stenosis.\"},{\"question\":\"What were the outcomes and follow-up results after treatment?\",\"answer\":\"The intervention rapidly relieved symptoms and resolved stenosis. The patient received anticoagulants and had no thrombosis at follow-up in August 2024.\"}]","Catheter-directed thrombectomy combined with angioplasty and stent implantation for superior vena cava syndrome - a case report | PDF",1790726886]