[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-360081-105":59,"doc-detail-360081-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","castration-resistance-accelerates-prostate-cancer-kinetics","Castration Resistance Accelerates Prostate Cancer Kinetics","","Background: Prostate cancer may remain indolent for years, making the timing of androgen deprivation therapy (ADT) and the emergence of treatment resistance critical. Although castration has been used for decades, castration resistance has not been systematically quantified in relation to prostate cancer progression. Prostate-specific antigen doubling time (PSADT) estimates kinetics and predicts survival, but whether PSADT changes with castration resistance is unclear. Methods: Longitudinal PSADT before castration and after development of castration resistance was assessed in 40 patients.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/castration-resistance-accelerates-prostate-cancer-kinetics/360081/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/castration-resistance-accelerates-prostate-cancer-kinetics/360081.png","ImageObject",300,407,{"name":92,"@type":93},"Rizky","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How was progression measured in the study?","Question",{"text":112,"@type":113},"Progression was quantified using prostate-specific antigen doubling time (PSADT), comparing values before castration and after castration resistance developed.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What key result links castration resistance to disease kinetics?",{"text":117,"@type":113},"Castration-resistant prostate cancer showed a markedly shorter CR-PSADT than castration-naïve PSADT, indicating accelerated kinetics after resistance.",{"name":119,"@type":110,"acceptedAnswer":120},"What do the findings suggest about survival and biological aggressiveness?",{"text":121,"@type":113},"CR-PSADT correlated positively with overall survival and, in a metastatic cohort, showed a negative correlation with the Ki-67 proliferation index, suggesting an association with tumor growth activity.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},360081,1790472599,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962085564807,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","The Prostate   \nORIGINAL ARTICLE   \nCastration Resistance Accelerates Prostate Cancer Kinetics  \nSheila Jonnatan1  | Luka Cavka1 | Angelo M. De Marzo1 | Samuel R. Denmeade1  | Mark C. Markowski1 | Emmanuel S. Antonarakis2 | Bruce J. Trock1  | Catherine H. Marshall1  | Ravi A. Madan3 | David J. Einstein4 | Laura A. Sena1  \n1Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA | 2Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA | 3Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA | 4Division of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA  \nCorrespondence: Laura A. Sena ([laura.sena@jhmi.edu](laura.sena@jhmi.edu))  \nReceived: 7 August 2025 | Revised: 16 February 2026 | Accepted: 30 March 2026  \nFunding: National Institutes of Health, Grant/Award Number: K08CA273167; Prostate Cancer Foundation  \nKeywords: cancer kinetics | castration resistance | Prostate cancer | prostate‐specific antigen doubling time  \nABSTRACT  \nBackground: Prostate cancer can be an indolent disease with which patients can live for many years. Thus, an understanding of how therapy and its ensuing resistance affect prostate cancer kinetics may guide efforts to determine optimal timing of therapy initiation. Despite the fact that castration has been used as therapy for prostate cancer for more than 70 years, no prior study has systematically quantified the effect of castration resistance on the rate of progression. The prostate‐specific antigen doubling time (PSADT) estimates prostate cancer kinetics and predicts overall survival, but whether PSADT changes as a result of castration resistance is not known.  \nMethods: Here, we studied the longitudinal change in the PSADT before castration and following the development of castration resistance in a cohort of 40 patients with prostate cancer.  \nResults: The PSADT of castration‐resistant prostate cancer (CR‐PSADT) was markedly shorter than the matched PSADT of castration‐naïve prostate cancer (CN‐PSADT) (median 2.6 months vs. 5.8 months, p \u003C 0.001) . The CR‐PSADT positively correlated with the CN‐PSADT and with overall survival. Sensitivity analysis suggested that the PSADT did not change as a function of time during progression when treatment was unchanged. Using a separate cohort of 36 patients with metastatic CRPC, we confirmed a positive correlation of CR‐PSADT with overall survival and identified a negative correlation with the Ki‐67 proliferation index of metastatic tumor biopsies.  \nConclusions: Castration‐resistant prostate cancer is associated with markedly accelerated disease kinetics compared with castration‐naïve prostate cancer. This acceleration of disease progression has the potential to shorten the survival of some patients with indolent disease who are treated prematurely with ADT.  \n1 | Introduction  \nThe current trend in the treatment of patients with a high risk of death from prostate cancer is earlier and more complete androgen receptor (AR) inhibition. Yet even patients who eventually die from prostate cancer can live with the disease for  \na long period of time with preserved quality of life. Given this, and that AR inhibition is generally not curative, appropriate timing of its deployment is important to maximize patient benefit and therefore has been a hotly debated and studied topic for many decades [1, 2] . A treatment resistance‐induced change in rate of progression may be an important variable to consider  \nThis is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.  \n© 2026 The Author(s) . The Prostate published by Wiley Periodicals LLC.  \nThe Prostate, 2026; 86:1021–1027 1021  \n[https://doi.org/10.1002/pros.70177](https://do","cbCaimhNcFZY5Yao","https://ap.wps.com/l/cbCaimhNcFZY5Yao","pdf",1295194,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction\n# Materials and Methods","[{\"question\":\"How was progression measured in the study?\",\"answer\":\"Progression was quantified using prostate-specific antigen doubling time (PSADT), comparing values before castration and after castration resistance developed.\"},{\"question\":\"What key result links castration resistance to disease kinetics?\",\"answer\":\"Castration-resistant prostate cancer showed a markedly shorter CR-PSADT than castration-naïve PSADT, indicating accelerated kinetics after resistance.\"},{\"question\":\"What do the findings suggest about survival and biological aggressiveness?\",\"answer\":\"CR-PSADT correlated positively with overall survival and, in a metastatic cohort, showed a negative correlation with the Ki-67 proliferation index, suggesting an association with tumor growth activity.\"}]","Castration Resistance Accelerates Prostate Cancer Kinetics | PDF",1790138709,18]