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This case report describes two elderly female patients with advanced thyroid carcinoma treated with the targeted combination dabrafenib and trametinib after diagnosis confirmation by ultrasound-guided fine-needle aspiration. Clinical symptoms improved markedly and tumors gradually shrank during follow-up. The authors conclude that this rare therapeutic modality may offer effective guidance for similar patients.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/case-report-visibly-curative-effect-of-dabrafenib-and-trametinib-on-advanced-thyroid-carcinoma-in-2-patients/384377/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/case-report-visibly-curative-effect-of-dabrafenib-and-trametinib-on-advanced-thyroid-carcinoma-in-2-patients/384377.png","ImageObject",300,407,{"name":92,"@type":93},"nayy☆","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What patient population and diagnoses are presented?","Question",{"text":112,"@type":113},"Two elderly female patients with advanced thyroid carcinoma are reported. Poorly differentiated thyroid carcinoma was confirmed for both patients through ultrasound-guided fine-needle aspiration.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the cases evaluated and monitored?",{"text":117,"@type":113},"Computed tomography and ultrasonography documented neck masses and visible compressions. Follow-up was used to track tumor shrinkage and symptom relief during treatment.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment and outcomes were reported?",{"text":121,"@type":113},"Both patients received dabrafenib and trametinib. Dyspnea and dysphagia improved significantly, and the tumors gradually decreased in size over the follow-up period.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},384377,1790655313,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090893153,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","TYPE Case Report  \nPUBLISHED 05 January 2023 DOI 10.3389/fonc.2022.1099268  \nOPEN ACCESS  \nEDITED BY  \nAkinfemi Akingboye,  \nDudley Group NHS Foundation Trust, United Kingdom  \nREVIEWED BY  \nZeyu Wu,  \nGuangdong Provincial People’s Hospital, China  \nAnkui Yang,  \nSun Yat-sen University Cancer Center (SYSUCC), China  \nXinying Li,  \nXiangya Hospital, Central South University, China  \n*CORRESPONDENCE  \nZhihui Li  \n [rockoliver@vip.sina.com](rockoliver@vip.sina.com)[ ](rockoliver@vip.sina.com)Kun Zhang  \n [zhangkun1989111@163.com](zhangkun1989111@163.com)  \nSPECIALTY SECTION  \nThis article was submitted to Surgical Oncology, a section of the journal Frontiers in Oncology  \nRECEIVED 15 November 2022  \nACCEPTED 13 December 2022  \nPUBLISHED 05 January 2023  \nCITATION  \nPeng X, Lei J, Li Z and Zhang K (2023) Case report: Visibly curative effect of  \ndabrafenib and trametinib on advanced thyroid carcinoma in 2 patients.  \nFront. Oncol. 12:1099268 .  \ndoi: 10.3389/fonc.2022.1099268  \nCOPYRIGHT  \n© 2023 Peng, Lei, Li and Zhang. This isan open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nCase report: Visibly curative effect of dabrafenib and trametinib on advanced thyroid carcinoma in 2 patients  \nXue Peng, Jianyong Lei, Zhihui Li* and Kun Zhang*  \nThyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu, China  \nBackground: Differentiated thyroid cancer accounts for the majority of thyroid cancers and has a good prognosis after standard treatment. However, there are still some complex and refractory thyroid cancers, including locally advanced differentiated thyroid carcinoma and medullary carcinoma (MTC), poorly differentiated thyroid carcinoma (PDTC), and anaplastic thyroid carcinoma (ATC) . Here, we report the therapeutic response of 2 advanced thyroid carcinoma patients treated with dabrafenib and trametinib.  \nCase presentation: Two elderly females presented to the clinic with neck masses, dyspnea, and dysphagia. Signs of the trachea and esophageal compression were markedly visible in computed tomography (CT) scan and ultrasonography. Pathologic diagnoses of PDTC were confirmed for both patients through ultrasound-guided fine-needle aspiration (US-FNA) . Both patients were significantly relieved from dyspnea and dysphagia after a course of treatment with dabrafenib and trametinib, and their tumors gradually shrank during the follow-up period.  \nConclusion: Overall, this treatment modality is rare, but effective. By sharing these 2 case reports, we hope to provide a reference for the treatment of clinically similar patients with advanced thyroid carcinoma.  \nKEYWORDS  \ndabrafenib, trametinib, lymph node metastasis, thyroid carcinoma, targeted drug  \nIntroduction  \nLocally advanced thyroid carcinoma is a type of thyroid cancer in which the tumor markedly invades surrounding organs and structures. Especially, poorly differentiated thyroid carcinoma is more aggressive and rapidly progresses to distant metastases. Poorly differentiated thyroid carcinoma is an aggressive form of follicular cell-derived thyroid  \nFrontiers in Oncology 01 [frontiersin.org](frontiersin.org)  \ncarcinoma with a behavior, morphology, and prognosis that is intermediate between indolent differentiated thyroid carcinoma (DTC) and rapidly growing and often fatal ATC (1). PDTC is a rare disease that was first described by Sakamoto in 1938 (2) and is reported to occur in 2% to 15% of all thyroid carcinomas (1, 3). Starting in 2004, the World Health Organization (WHO) classified PDTC as a non-follicular non-papillary, thyroglobulin-producing thyroid carcino","cbCaij852vmQn8qT","https://ap.wps.com/l/cbCaij852vmQn8qT","pdf",2994818,"English","# Background\n# Case presentation\n## Case 1\n## Case 2\n# Conclusion\n# Keywords\n# Introduction","[{\"question\":\"What patient population and diagnoses are presented?\",\"answer\":\"Two elderly female patients with advanced thyroid carcinoma are reported. Poorly differentiated thyroid carcinoma was confirmed for both patients through ultrasound-guided fine-needle aspiration.\"},{\"question\":\"How were the cases evaluated and monitored?\",\"answer\":\"Computed tomography and ultrasonography documented neck masses and visible compressions. Follow-up was used to track tumor shrinkage and symptom relief during treatment.\"},{\"question\":\"What treatment and outcomes were reported?\",\"answer\":\"Both patients received dabrafenib and trametinib. Dyspnea and dysphagia improved significantly, and the tumors gradually decreased in size over the follow-up period.\"}]","Case report - Visibly curative effect of dabrafenib and trametinib on advanced thyroid carcinoma in 2 patients | PDF",1790262937,18]