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Dermatologic management is described, but surgical experience with wound treatment is limited. This report details surgical management of chronic lower-limb traumatic wounds resistant to conservative dermatological therapy in a 35-year-old male with KID syndrome, including debridement, excision, and targeted antimicrobial approaches.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/case-report-of-wound-treatment-with-hyiodine-gel-in-an-occasional-kid-syndrome-patient/461528/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/case-report-of-wound-treatment-with-hyiodine-gel-in-an-occasional-kid-syndrome-patient/461528.png","ImageObject",300,407,{"name":92,"@type":93},"A glass of water","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-06","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main clinical problem addressed in this case report?","Question",{"text":112,"@type":113},"The report addresses chronic traumatic wounds of both lower limbs in a patient with KID syndrome that did not respond to conservative dermatological therapy.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What surgical steps were used when outpatient treatment was insufficient?",{"text":117,"@type":113},"After minimal improvement for three months, the inpatient approach included complete excision of hyperkeratotic tissue and creation of a wide ulcer bed, alongside systemic and topical therapies.",{"name":119,"@type":110,"acceptedAnswer":120},"How did the combined therapies affect the wound outcome?",{"text":121,"@type":113},"Combined systemic antibiotic and antipsoriatic therapy with topical sodium hyaluronate and iodine supported gradual wound healing and improved skin condition without major complications.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},461528,1790815818,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090760832,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Case Report  \nCase Report of Wound Treatment with Hyiodine Gel in an Occasional KID Syndrome Patient  \nMarianna Hajská 1, Silvia Bittner Fialová 2, *, Martin Dubovský 1 and Arpád Panyko 1  \n1 Comenius University Bratislava, Faculty of Medicine and University Hospital, 4th Department of Surgery, Bratislava, Ružinovská 6, 82606 Bratislava, Slovakia; marianna.hajska@fmed.uniba.sk (M.H.);  \nmartin.dubovsky@fmed.uniba.sk (M.D.); arpad.panyko@fmed.uniba.sk (A.P.)  \n2 Comenius University Bratislava, Faculty of Pharmacy, Department of Pharmacognosy and Botany, Odbojárov 10, 83232 Bratislava, Slovakia  \n* [Correspondence: fialova@fpharm.uniba.sk](Correspondence: fialova@fpharm.uniba.sk)  \nAbstract  \nBackground/Objectives: Keratitis–ichthyosis–deafness (KID) syndrome is an exceptionally rare congenital multisystem disorder, with an estimated prevalence below 1:1,000,000 and fewer than 100 reported cases worldwide. It is characterized by hyperkeratosis, alopecia, nail dystrophy, hearing loss, and ocular involvement. While dermatological management is well described, surgical experience with wound treatment in KID syndrome remains extremely limited. The objective of this report is to describe the surgical management and outcomes of a patient with chronic lower-limb wounds associated with KID syndrome. Methods: A 35-year-old male with KID syndrome was referred to the surgical outpatient clinic for chronic traumatic wounds of both lower limbs resistant to conservative dermatological therapy. Initial outpatient treatment included serial sharp surgical debridement under local anesthesia, combined with topical keratolytics and silver sulfadiazine with hyaluronic acid. Due to minimal improvement after three months, an inpatient surgical approach was initiated, involving complete excision of hyperkeratotic tissue, creation of a wide ulcer bed, and adjunct systemic and topical therapies. Results: The inpatient management enabled thorough removal of pathological tissue and better control of local infection and inflammation. Combined systemic antibiotic and antipsoriatic therapy, together with topical sodium hyaluronate and iodine, was associated with gradual wound healing and improved skin condition. The patient tolerated the procedures well, without major complications. Conclusions: Surgical debridement and excision, when combined with targeted dermatological and antimicrobial therapy, can be an effective and safe strategy for managing chronic wounds in KID syndrome. This case highlights the importance of multidisciplinary collaboration and individualized surgical planning in this extremely rare disorder.  \nAcademic Editor: Hajime Matsumura  \nReceived: 13 November 2025  \nRevised: 16 December 2025  \nAccepted: 17 December 2025  \nPublished: 19 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \nKeywords: keratitis–ichthyosis–deafness (KID) syndrome; chronic wounds; surgical debridement; hyperkeratosis; multidisciplinary management  \n1. Introduction  \nKeratitis–ichthyosis–deafness (KID) syndrome is a sporadic genetic disorder with an estimated prevalence below 1:1,000,000, and approximately one hundred patients have been described in the literature [1] . The disease results from heterozygous mutations in the GJB2 gene encoding connexin-26 (Cx26), a structural component of gap junction channels responsible for ionic and metabolic intercellular communication [2] . The GJB2 gene is  \nexpressed in a variety of tissues, including several ectodermal epithelia affected in KID syndrome: the corneal epithelium, epidermis of skin, cochlea, and hair follicles [3] . Pathogenic mutations lead to hemichannel dysfunction and impaired keratinocyte differentiation, clinically manifesting as hyperkeratosis, impaired skin barrier, inflammatory complications, and frequent infections. The classical triad","cbCaibqKwBbYyxqx","https://ap.wps.com/l/cbCaibqKwBbYyxqx","pdf",923001,"English","# Abstract\n## Background/Objectives\n## Methods\n## Results\n## Conclusions\n# 1. Introduction","[{\"question\":\"What is the main clinical problem addressed in this case report?\",\"answer\":\"The report addresses chronic traumatic wounds of both lower limbs in a patient with KID syndrome that did not respond to conservative dermatological therapy.\"},{\"question\":\"What surgical steps were used when outpatient treatment was insufficient?\",\"answer\":\"After minimal improvement for three months, the inpatient approach included complete excision of hyperkeratotic tissue and creation of a wide ulcer bed, alongside systemic and topical therapies.\"},{\"question\":\"How did the combined therapies affect the wound outcome?\",\"answer\":\"Combined systemic antibiotic and antipsoriatic therapy with topical sodium hyaluronate and iodine supported gradual wound healing and improved skin condition without major complications.\"}]","Case Report of Wound Treatment with Hyiodine Gel in an Occasional KID Syndrome Patient | PDF",1790761802,23]