[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-327816-105":59,"doc-detail-327816-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","case-report-of-multiple-primary-cancers-and-results-of-genetic-testing-to-preliminarily-explore-their-pathogenesis-study","Case report of multiple primary cancers and results of genetic testing to preliminarily explore their pathogenesis - study","","Multiple primary malignancies arising in one patient are uncommon. This case describes a 71-year-old man diagnosed with three primary tumors: lung cancer, intrahepatic cholangiocarcinoma, and prostate cancer, along with an initial genetic investigation into mechanisms driving multiple tumor development. Due to late-stage disease, high tumor burden, and poor physical condition, survival was only a few months. Whole-exome sequencing detected multiple gene mutations involving proliferation, cell-cycle regulation, genetic stability, metabolism, invasion, angiogenesis, and apoptosis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/case-report-of-multiple-primary-cancers-and-results-of-genetic-testing-to-preliminarily-explore-their-pathogenesis-study/327816/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/case-report-of-multiple-primary-cancers-and-results-of-genetic-testing-to-preliminarily-explore-their-pathogenesis-study/327816.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-21","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What cancers were identified in the reported patient?","Question",{"text":112,"@type":113},"The patient was found to have three primary tumors simultaneously: lung cancer, intrahepatic cholangiocarcinoma, and prostate cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What genetic method was used to explore the mechanism of multiple primary cancers?",{"text":117,"@type":113},"Whole-exome sequencing was performed on pathological tissues to investigate potential genetic mechanisms behind multiple primary tumors.",{"name":119,"@type":110,"acceptedAnswer":120},"Which biological pathways were implicated by detected gene mutations?",{"text":121,"@type":113},"The reported mutations involved pathways related to cell proliferation, cell cycle regulation, genetic stability, metabolism, cell invasion, angiogenesis, and cell apoptosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},327816,1789999649,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","Case report of multiple primary cancersand results of genetic testing to preliminarily explore their pathogenesis  \nZhao Hong 1*, Zhang Tongsong2*, Chen Cunhai3,4, Li Xiao3,4 and Song Haiping3,4  \nSAGE Open Medical Case Reports Volume 12: 1–6 © The Author(s) 2024 Article reuse guidelines:  \n[sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/2050313X241252371](DOI: 10.1177/2050313X241252371)[ ](DOI: 10.1177/2050313X241252371)[journals.sagepub.com/home/sco](journals.sagepub.com/home/sco)  \nAbstract  \nThe occurrence of multiple primary malignancies in a single patient has been relatively rare. We report here the case of a 71-year-old man with three primary tumors of lung cancer, intrahepatic cholangiocarcinoma, and prostate cancer, and a preliminary study of the mechanisms by which multiple primary tumors develop at the genetic level. Because of the late stage of the patient's condition, large tumor burden, and poor physical status, the patient survived only a few months. In the case presented herein, cholangiocarcinoma, lung cancer, and prostate cancer were found simultaneously, and the pathogenic sites are not related. Whole-exome sequencing was performed on the pathological tissues to explore the mechanism that may underlie multiple primary cancers at the genetic level. Several gene mutations were found in this case. They involved cell proliferation, cell cycle regulation, genetic stability, metabolism, cell invasion, angiogenesis, cell apoptosis, and other pathways. It can be preliminarily inferred that the mechanism underlying multiple primary tumors is related to the abnormality of tumor-promoting and suppressing pathways.  \nKeywords  \nGenetic mutation, whole-exome sequencing, multiple primary cancer, case report  \nDate received: 29 November 2023; accepted: 16 April 2024  \nIntroduction  \nIn recent years, the tumor detection rate has increased, and some patients are found to have multiple primary cancers (MPCs) . MPCs often occur in the digestive, respiratory, and urinary systems.1–4 The site of second primary cancer is closely related to the site of the first primary cancer, and the diagnosis is based on the standards established by Warren and Gates in 1932.4 The most famous pathogenesis ofMPCis the theory of field cancerization proposed by Slaughter et [al. in](al. in) 1953 to explain the development of head and necksquamous cell carcinoma, which is often accompanied by multiple malignant or precancerous lesions.5  \nThere is no standard treatment plan or recommendation for MPCs; thus, treatment remains difficult. Treating tumors according to the type of gene mutation may provide a new direction for the diagnosis and treatment of MPCs. We here report, for the first time, a case of three primary tumors of lung cancer, intrahepatic cholangiocarcinoma, and prostate cancer, and a preliminary study of the mechanisms by which multiple primary tumors develop at the genetic level.  \nCase presentation  \nThe patient, male, 71 years old, with a previous history of hypertension anamnesis, with no family history of cancer, was admitted to the hospital with “upper abdominal distension for 5 months, aggravated for half a month” on March 9, 2020. He  \n1 Department of Gastroenterology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences Qingdao Central Hospital, Qingdao, China 2Department of Radiotherapy, Qilu Hospital of Shandong University (Qingdao), Qingdao, China  \n3Department of Internal Medicine-Oncology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences Qingdao Central Hospital, Qingdao, China  \n4Department of Internal Medicine-Oncology, Qingdao Tumor Hospital, Qingdao, China  \n*These authors share the co-first authorship.  \nCorresponding Author:  \nSong Haiping, Department of Internal Medicine-Oncology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences Qingdao Central Hospitall, 127 Siliu South ","cbCaie8lJWsoDWWn","https://ap.wps.com/l/cbCaie8lJWsoDWWn","pdf",1297080,"English","# Abstract\n# Keywords\n# Introduction\n# Case presentation\n# Figures","[{\"question\":\"What cancers were identified in the reported patient?\",\"answer\":\"The patient was found to have three primary tumors simultaneously: lung cancer, intrahepatic cholangiocarcinoma, and prostate cancer.\"},{\"question\":\"What genetic method was used to explore the mechanism of multiple primary cancers?\",\"answer\":\"Whole-exome sequencing was performed on pathological tissues to investigate potential genetic mechanisms behind multiple primary tumors.\"},{\"question\":\"Which biological pathways were implicated by detected gene mutations?\",\"answer\":\"The reported mutations involved pathways related to cell proliferation, cell cycle regulation, genetic stability, metabolism, cell invasion, angiogenesis, and cell apoptosis.\"}]","Case report of multiple primary cancers and results of genetic testing to preliminarily explore their pathogenesis - study | PDF",1789978124,15]