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This report describes a 66-year-old man with early-stage collisional squamous cell carcinoma and adenoid cystic carcinoma detected by endoscopy. Endoscopic submucosal dissection guided by magnification and endoscopic ultrasonography achieved complete removal. Follow-up for six months showed no recurrence. 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In the digestive system, it is more common in large glands such as the liver and pancreas, and it is rarer in the esophagus.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the early esophageal collision cancer detected and treated?",{"text":117,"@type":113},"The lesion was detected in early stages by endoscopy. High-grade squamous intraepithelial neoplasia was identified on biopsy, and the tumor was removed by endoscopic submucosal dissection (ESD) using magnification endoscopy and endoscopic ultrasonography.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the pathology findings and the follow-up outcome?",{"text":121,"@type":113},"Postoperative pathology confirmed collision cancer composed of squamous cell carcinoma (SqCC) and adenoid cystic carcinoma (AdCC). After six months of postoperative follow-up, there was no recurrence.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},377590,1790746340,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090894170,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","TYPE Case Report  \nPUBLISHED 02 February 2023 DOI 10.3389/fonc.2023.1072336  \nOPEN ACCESS  \nEDITED BY  \nRupert Langer,  \nUniversity of Bern, Switzerland  \nREVIEWED BY  \nJean-Philippe Ratone,  \nInstitut Paoli-Calmettes (IPC), France Gianni Lazzarin,  \nAbano Terme Hospital, Italy  \n*CORRESPONDENCE Shutian Zhang  \n [zhangshutian@ccmu.edu.cn](zhangshutian@ccmu.edu.cn)[ ](zhangshutian@ccmu.edu.cn)Qiaozhi Zhou  \n [zhouqzh@sina.com](zhouqzh@sina.com)  \n†These authors have contributed equally to this work and share first authorship  \n‡These authors have contributed equally to this work and share last authorship  \nSPECIALTY SECTION  \nThis article was submitted to Gastrointestinal Cancers: Gastric and  \nEsophageal Cancers, a section of the journal Frontiers in Oncology  \nRECEIVED 17 October 2022  \nACCEPTED 23 January 2023  \nPUBLISHED 02 February 2023  \nCITATION  \nLiang Z, Wei Y, Li P, Xu R, Zhou Q and Zhang S (2023) Case report: First case of early adenoid cystic carcinoma and squamous cell carcinoma collision cancer treated by endoscopic  \nsubmucosal dissection.  \nFront. Oncol. 13:1072336 .  \ndoi: 10.3389/fonc.2023.1072336  \nCOPYRIGHT  \n© 2023 Liang, Wei, Li, Xu, Zhou and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nCase report: First case of early adenoid cystic carcinoma and squamous cell carcinoma collision cancer treated by endoscopic submucosal dissection  \nZheng Liang 1†, Yongqiu Wei 1†, Peng Li 1, Rui Xu 2, Qiaozhi Zhou 1*‡ and Shutian Zhang 1*‡  \n1 Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing, China, 2 Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, China  \nBackground: Collision cancer, a rare tumor, rarely occurs in the esophagus. Most reported cases of esophageal collision cancers are advanced cancers that can only be treated with surgery or palliative chemoradiotherapy. Here, we report a rare case of collisional squamous cell carcinoma (SqCC) and adenoid cystic carcinoma (AdCC) that was detected in the early stages by endoscopy.  \nCase summary: A 66-year-old man presented with retrosternal pain after swallowing and underwent endoscopy. Pathological biopsy showed high-gradesquamous intraepithelial neoplasia. The lesion was removed by endoscopic submucosal dissection (ES D) after magnification and endo sco pic ultrasonography. Postoperative pathology proved that the lesion was collision cancer comprising SqCC and AdCC. After six months of postoperative follow-up, there was no recurrence of esophageal cancer.  \nConclusions: We provided a case report related to the diagnosis and treatment of esophageal collision cancer, especially early collision cancer. More research is needed to provide insights into the management of collision cancers.  \nKEYWORDS  \ncollision cancer, early esophageal cancer, esophageal squamous cell carcinoma, esophageal adenoid cystic carcinoma, endoscopic submucosal dissection  \nAbbreviations: AdCC, Adenoid cystic carcinoma; ASC, Adenosquamous carcinoma; ADC, adenocarcinoma; AVA, Avascular area; BLI-ME, Blue laser imaging magnifying endoscope; ESD, Endoscopic submucosal dissection; GIST, Gastrointestinal stromal tumor; NBI, Narrowband light imaging; SmCC, Small cell carcinoma; SMT, Submucosal tumor; SqCC, Squamous cell carcinoma.  \nFrontiers in Oncology 01 [frontiersin.org](frontiersin.org)  \nIntroduction  \nCollision cancer refers to a tumor that occurs at the same site but originates from two tissues that infiltrate each other but do not migrate to each o","cbCaimdZT8I0hlJb","https://ap.wps.com/l/cbCaimdZT8I0hlJb","pdf",2295658,"English","# Introduction\n# Case description\n# Case summary\n# Conclusions","[{\"question\":\"What is collision cancer in the esophagus?\",\"answer\":\"Collision cancer refers to tumors that arise at the same site from two tissues that infiltrate each other without migrating into each other. In the digestive system, it is more common in large glands such as the liver and pancreas, and it is rarer in the esophagus.\"},{\"question\":\"How was the early esophageal collision cancer detected and treated?\",\"answer\":\"The lesion was detected in early stages by endoscopy. High-grade squamous intraepithelial neoplasia was identified on biopsy, and the tumor was removed by endoscopic submucosal dissection (ESD) using magnification endoscopy and endoscopic ultrasonography.\"},{\"question\":\"What were the pathology findings and the follow-up outcome?\",\"answer\":\"Postoperative pathology confirmed collision cancer composed of squamous cell carcinoma (SqCC) and adenoid cystic carcinoma (AdCC). After six months of postoperative follow-up, there was no recurrence.\"}]","Case report: First case of early adenoid cystic carcinoma and squamous cell carcinoma collision cancer treated by endoscopic submucosal dissection | PDF",1790226125,15]