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Basal cell-type carcinoma of the prostate is exceptionally rare, often lacking PSA secretion and therefore presenting with nonspecific symptoms typical of BPH and frequently at locally advanced stages. This report describes a U.S. Vietnam veteran exposed to Agent Orange who was diagnosed with multiple distinct prostate cancer types, initially BCCP treated with definitive radiotherapy, later developing localized prostatic adenocarcinoma managed with salvage high-intensity focused ultrasound, with no recurrence 60 months later.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/case-of-basal-cell-prostate-cancer-and-recurrence-with-prostatic-adenocarcinoma-in-a-united-states-military-veteran-exposed-to-agent-orange/360665/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/case-of-basal-cell-prostate-cancer-and-recurrence-with-prostatic-adenocarcinoma-in-a-united-states-military-veteran-exposed-to-agent-orange/360665.png","ImageObject",300,407,{"name":92,"@type":93},"Franzy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is basal cell-type prostate carcinoma difficult to detect early?","Question",{"text":113,"@type":114},"It does not usually secrete PSA and often presents with symptoms similar to typical BPH, leading to diagnoses at more advanced stages.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What exposure and diagnosis are described in the case report?",{"text":118,"@type":114},"A U.S. Vietnam veteran with Agent Orange exposure was diagnosed with basal cell-type prostate carcinoma and later developed localized prostatic adenocarcinoma.",{"name":120,"@type":111,"acceptedAnswer":121},"How was recurrence managed, and what was the outcome by follow-up?",{"text":122,"@type":114},"The recurrence was treated with salvage high-intensity focused ultrasound (S-HIFU), and the patient remained without recurrence for 60 months after the procedure.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},360665,1790194240,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336478945519,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Clinical Case Reports  \nCASE REPORT  OPEN ACCESS   \nCase of Basal Cell Prostate Cancer and Recurrence With Prostatic Adenocarcinoma in a United States Military Veteran Exposed to Agent Orange  \nGerman Santiago Herrera Alzate1  | Piroz Bahar1 | Daniel S. Levin1 | Andrew Wood2 | Arvin K. George3 | Paul J. Chuba4  \n1University of Michigan Medical School, Ann Arbor, Michigan, USA | 2Department of Urology, Michigan Medicine, Ann Arbor, Michigan,  \nUSA | 3Department of Urology, Johns Hopkins Medicine, Baltimore, Maryland, USA | 4Henry Ford Hospital, Detroit, Michigan, USA Correspondence: German Santiago Herrera Alzate ([geherrer@med.umich.edu](geherrer@med.umich.edu))  \nReceived: 7 July 2025 | Revised: 7 March 2026 | Accepted: 19 June 2026  \nKeywords: Agent Orange | basal cell carcinoma | high-intensity focused ultrasound ablation | prostatic neoplasms  \nABSTRACT  \nProstate cancer is the most commonly diagnosed cancer and the second leading cause of cancer death in men. Acinar adenocarcinoma accounts for 90% of primary prostatic cancers. Carcinoma of the basal cells of the prostate is extremely rare, making up less than 1% of prostate cancer diagnoses. As opposed to adenocarcinoma, basal cell-type carcinoma of the prostate (BCCP) does not usually secrete PSA and most commonly presents with symptoms of typical BPH. Due to its nonspecific symptoms and absence of PSA secretion, it is often diagnosed at the locally advanced stage. In part due to its rarity, there are no standardized treatment protocols. Agent Orange (AO) is a pesticide utilized by the US Military during the Vietnam War, which was contaminated with polychlorinated dibenzo-dioxins (PCDDs) . These compounds have been linked to the development of various malignancies, including prostate cancer, although a direct causal relationship remains unproven. We present the case of a US Vietnam Veteran with Agent Orange exposure who was diagnosed with multiple distinct types of prostate cancer, including BCCP. He was initially found to have BCCP on pathological evaluation of prostate tissue from a prostatic resection for BPH. He was treated with definitive radiotherapy. He subsequently developed a recurrence of prostate cancer, but on this occasion, he was found to have localized prostatic adenocarcinoma and was treated with salvage High Intensity-Focused Ultrasound (S-HIFU) . He remained without recurrence to the time of the writing of this report, 60 months after undergoing S-HIFU. Upon review of the literature, there is a lack of data regarding the environmental exposures of patients who develop BCCP, as well as a lack of documentation of rare subtypes of prostate cancers that have been identified in AO-exposed Veterans. Further studies on this subject would be beneficial, as there are millions of US veterans alive who had exposure to PCDDs during the Vietnam War and the more recent Global War on Terror.  \n1 | Introduction  \nIn 2025, there are estimated to be 1,053,250 new cases of cancer diagnosed in men in the United States, with prostate cancer making up 30% of these new cases [1] . Though there has been a recent decrease in cancer mortality overall, prostate cancer maintains a high mortality burden as the second leading cause of cancer death in men [2] . 90% of prostate cancers are acinar  \nepithelial in origin, originating from secretory acini, and present as adenocarcinoma [3, 4]. Non-acinar variants make up less than 2% . Within this category, basal cell-type epithelial carcinoma of the prostate (BCCP) is an extraordinarily rare subtype, making up less than 0.01% of prostate cancers [5] . As opposed to adenocarcinoma, BCCP does not secrete PSA, making it more difficult to identify on routine screening [6]. Due to the rarity of this subtype, a standard treatment modality has not been established.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original w","cbCaiqqpaBrLrSUY","https://ap.wps.com/l/cbCaiqqpaBrLrSUY","pdf",783334,"English","# Abstract\n# Introduction\n## Prostate cancer epidemiology and PSA screening challenges\n## Basal cell-type carcinoma rarity and treatment uncertainty\n# Key clinical message","[{\"question\":\"Why is basal cell-type prostate carcinoma difficult to detect early?\",\"answer\":\"It does not usually secrete PSA and often presents with symptoms similar to typical BPH, leading to diagnoses at more advanced stages.\"},{\"question\":\"What exposure and diagnosis are described in the case report?\",\"answer\":\"A U.S. Vietnam veteran with Agent Orange exposure was diagnosed with basal cell-type prostate carcinoma and later developed localized prostatic adenocarcinoma.\"},{\"question\":\"How was recurrence managed, and what was the outcome by follow-up?\",\"answer\":\"The recurrence was treated with salvage high-intensity focused ultrasound (S-HIFU), and the patient remained without recurrence for 60 months after the procedure.\"}]","Case of Basal Cell Prostate Cancer and Recurrence With Prostatic Adenocarcinoma in a United States Military Veteran Exposed to Agent Orange | PDF",1790140996,15]