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Surgical resection is the most effective treatment, yet timing and approach are controversial; this review consolidates evidence, highlights key risks, and discusses modern strategies.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/cardiac-myxoma-and-its-implications-for-cardioembolic-stroke-minireviews/406180/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/cardiac-myxoma-and-its-implications-for-cardioembolic-stroke-minireviews/406180.png","ImageObject",300,407,{"name":42,"@type":43},"Quinn Holloway","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What mechanisms explain CM-related ischemic stroke (CM-IS)?","Question",{"text":63,"@type":64},"CM-IS is associated with embolism from detached tumor debris and metastatic infiltration by the myxoma.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Why is diagnosis of CM-IS challenging?",{"text":68,"@type":64},"Diagnosis requires a comprehensive evaluation of clinical manifestations, imaging findings, and laboratory results, and histopathological examination is needed for definitive confirmation.",{"name":70,"@type":61,"acceptedAnswer":71},"What is the most effective treatment for CM-IS?",{"text":72,"@type":64},"Surgical resection of the myxoma is described as the most effective CM-IS treatment, although optimal timing and approach remain controversial.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},406180,1790718958,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":111,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":117,"preview_page_count":4},2336474466712,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","| W | J | C | World Journal of\u003Cbr>Cardiology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Cardiol 2025 December 26; 17(12): 112396  \nDOI: 10.4330/wjc.v17.i12.112396 ISSN 1949-8462 (online)  \nMINIREVIEWS  \nCardiac myxoma and its implications for cardioembolic stroke  \nBin Cai, Man-Li Qiao, Dan Miao, Guang-Zhi Liu  \nSpecialty type: Cardiac and cardiovascular systems  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B, Grade C  \nNovelty: Grade C, Grade C  \nCreativity or Innovation: Grade C, Grade C  \nScientific Significance: Grade B, Grade C  \nP-Reviewer: Arboix A, MD, PhD, Associate Professor, Spain  \nReceived: July 27, 2025  \nRevised: September 4, 2025  \nAccepted: November 13, 2025  \nPublished online: December 26, 2025  \nProcessing time: 152 Days and 1.1 Hours  \nBin Cai, Guang-Zhi Liu, Department of Neurology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing 100144, China  \nMan-Li Qiao, Department of General Practice, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China  \nDan Miao, Department of Neurology, Qingdao Hiser Hospital Affiliated of Qingdao University/Qingdao Traditional Chinese Medicine Hospital, Qingdao 266011, Shandong Province, China  \nCorresponding author: Guang-Zhi Liu, MD, PhD, Professor, Department of Neurology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, No. 33 Badachu Road, Shijingshan District, Beijing 100144, [China.](China. guangzhi2002@hotmail.com)[ guangzhi2002@hotmail.com](China. guangzhi2002@hotmail.com)  \nAbstract  \nCardiac myxoma (CM) is the most common type of primary cardiac tumor and a major embolic source of cardioembolic stroke. Two potential causative mechanisms are associated with CM-related ischemic stroke (CM-IS): Embolism from detached tumor debris and metastatic infiltration. The risk factors for embolism from CM remain unclear and are widely debated in the literature. CM-IS often initially presents with central nervous system complications. Diagnosis requires a comprehensive assessment of clinical manifestations, imaging findings, and laboratory test results, with histopathological examination required for a definitive diagnosis. Surgical resection of myxoma is the most effective CM-IS treatment, although the optimal timing and approach remain controversial. This review consolidates the current knowledge on CM-IS, identifies critical risk factors for embolic complications, and discusses contemporary treatment str-ategies, emphasizing the need for individualized management protocols and further research to improve outcomes in affected patients.  \nKey Words: Myxoma; Cerebral embolism; Cardioembolic stroke; Ischemic stroke; Mechanism; Risk factors; Diagnosis; Treatment  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJC  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 26, 2025  Volume 17  Issue 12   \nCai B et al. Clarifying the connection between atrial myxoma and stroke  \nCore Tip: Cardiac myxoma, although rare, is a significant cause of cardioembolic stroke in young adults, often due to embolism from tumor fragments or metastatic spread. The link between tumor mobility, morphology, and stroke risk remains unclear. This article explores the relationship between cardiac myxoma and ischemic stroke (CM-IS), highlighting two potential pathogenetic mechanisms and identifying tumor morphology and mobility as critical risk factors. CM-IS predominantly affects younger patients presenting with acute neurological symptoms, necessitating tailored diagnostic and therapeutic approaches. The analysis highlights the complexity of CM-IS and calls for further research to refine its management and support clinical decision making.  \nCitation: Cai B, Qiao ML, Miao D, Liu GZ. Cardiac myxoma and","cbCaidZ6xmXvxVps","https://ap.wps.com/l/cbCaidZ6xmXvxVps","pdf",1865648,"English","# Introduction\n# Methods (Updated Review Search Strategy)\n## Databases and time window\n## Inclusion and exclusion criteria","[{\"question\":\"What mechanisms explain CM-related ischemic stroke (CM-IS)?\",\"answer\":\"CM-IS is associated with embolism from detached tumor debris and metastatic infiltration by the myxoma.\"},{\"question\":\"Why is diagnosis of CM-IS challenging?\",\"answer\":\"Diagnosis requires a comprehensive evaluation of clinical manifestations, imaging findings, and laboratory results, and histopathological examination is needed for definitive confirmation.\"},{\"question\":\"What is the most effective treatment for CM-IS?\",\"answer\":\"Surgical resection of the myxoma is described as the most effective CM-IS treatment, although optimal timing and approach remain controversial.\"}]","Cardiac myxoma and its implications for cardioembolic stroke - MiniReviews | PDF",1790563988]