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|  |\n| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |\n| CARB-X GRADUATES-THERAPEUTICS |  |  |  |  |  |  |  |  |  |  |\n| Novelty* |  |  |  |  |  | Development Stage |  |  |  |  |\n| \u003Cbr>Product Developer & Graduation Date\u003Cbr>Peptilogics 12/24 | Product\u003Cbr>PLG0206: Direct-acting engineered peptides | Bacteria\u003Cbr>Broad spectrum | New\u003Cbr>Abx\u003Cbr>Cls\u003Cbr> • \u003Cbr>•\u003Cbr>•\u003Cbr>• | New\u003Cbr>Abx\u003Cbr>Tgt | Non\u003Cbr>trad\u003Cbr> • \u003Cbr>•\u003Cbr>•\u003Cbr>• | Hit-to-lead | Lead\u003Cbr>Optimization |  | Pre-Clinical | Phase 1 |\n|  |  |  |  |  |  |  |  |  |  | |\n|  |  |  |  |  |  |  |  |  |  |  |\n| Trellis Bioscience 5/24\u003Cbr>Clarametyx Biosciences 11/22 | TRL1068: Antibiofilm monoclonal antibody\u003Cbr>CMTX-101: Antibiofilm Monoclonal Antibody | Broad spectrum\u003Cbr>ESKAPE, MRSA |  | •\u003Cbr>•\u003Cbr>• |  |  |  |  | \u003Cbr>| |\n|  |  |  |  |  |  |  |  |  |  |  |\n|  |  |  |  |  |  |  |  |  | |  |\n|  |  |  |  |  |  |  |  |  |  |  |\n| GlaxoSmithKline 12/21 | GSK3882347: FimH Antagonist UTI | E. coli |  |  |  |  |  |  |  |  |\n|  |  |  |  |  |  |  |  |  |  |  |\n| Entasis Tx. 12/20 | ETX0282CPDP: Oral Combination | Gram-negative pathogens |  |  |  |  |  |  |  | |\n| Tetraphase 06/19 | TP-6076: Novel Fluorocycline | Acinetobacter, Enterobacteriaceae |  |  |  |  |  |  |  |  |\n|  |  |  |  |  |  |  |  |  |  |  |\n| Iterum 03/19 | Sulopenem | Gram-negative activity |  |  |  |  |  |  |  |  |\n|  |  |  |  |  |  |  |  |  |  | |\n| Spero 03/18 | SPR741: Antibiotic Potentiator | Gram-negative activity | • |  | • |  |  |  |  | |\n|  |  |  |  |  |  |  |  |  |  |  |\n| Oppilotech 10/17 | LPS | Gram-negative pathogens |  |  |  |  |  |  |  |  |\n| CARB-X GRADUATES-PREVENTATIVES |  |  |  |  |  |  |  |  |  |  |\n| Novelty* |  |  |  |  |  | Development Stage |  |  |  |  |\n| \u003Cbr>Product Developer & Graduation Date\u003Cbr>GlaxoSmithKline 06/25 | Product\u003Cbr>GSK iNTS-TCV iNTS-typhoid conjugate vaccine | Bacteria\u003Cbr>Salmonella enterica | Type\u003Cbr>Vaccine |  |  | Hit-to-lead | Lead\u003Cbr>Optimization |  | Pre-Clinical | Phase 1 |\n|  |  |  |  |  |  |  |  |  |  | |\n|  |  |  |  |  |  |  |  |  |  |  |\n| Seres 04/21 | SER-155: LBP Cocktail Preventative | Broad spectrum activity vs CRE/VRE | Microbiome |  |  |  | |  | |  |\n|  |  |  |  |  |  |  |  |  |  |  |\n| Vedanta 09/18 | VE303: LBP Cocktail Preventative | C.difficile | Microbiome |  |  |  |  |  |  |  |\n| CARB-X GRADUATES-DIAGNOSTICS |  |  |  |  |  |  |  |  |  |  |\n| Development Stage |  |  |  |  |  |  |  |  |  |  |\n| Product Developer & Graduation Date | Product | Syndrome | Healthcare\u003Cbr>Level |  |  | Feasibility | Optimization |  | Develop\u003Cbr>ment | Verification & Validation |\n| Pattern Bioscience 06/23 | Digital culture single cell biometric analysis | Lower respiratory tract infections | LIV |  |  |  | |  | |  |\n|  |  |  |  |  |  |  |  |  |  |  |\n| Helixbind 03/22 | Rapid/BSI, Automated culture-free | Bloodstream infections | LIV |  |  |  |  |  |  | |\n| Proteus 02/22 | Rapid POC Dx, Optical bacterial imaging | Lower respiratory tract infections | LIV |  |  |  |  |  |  |  |\n|  |  |  |  |  |  |  |  |  |  | |\n|  |  |  |  |  |  |  |  |  |  |  |\n| Specific Diagnostics 03/20 | SPECIFAST REVEAL™, Colorimetric Sensor Array to detect VOCs | Bloodstream infections | LIV |  |  |  |  |  |  | |\n|  |  |  |  |  |  |  |  |  |  |  |\n| T2 Biosystems 09/19 | Expanded bacteria and resistance panels for T2Dx | Bloodstream infections | LIV |  |  |  |  |  | | |\n|  |  |  |  |  |  |  |  |  |  |  |\n| *Note: Regarding CARB-X graduates, red bars represent Development Stage while in the CARB-X porfolio, and pink bars represent Development Stage progress after graduating from the CARB-X program. |  |  |  |  |  |  |  |  |  |  |\n|  |  |  |  |  |  |  |  |  |  |  |\n| Active Product Pipeline, as of 6/30/25\u003Cbr>Products currently funded and supported by CARB-X |  |  |  |  |  |  |  |  |  |  |\n| ACTIVE-THERAPEUTICS PROJECTS |  |  |  |  |  |  |  |  |  |  |\n| Product Developer\u003Cbr>ArrePath","cbCaijF8JMbfRp2f","https://ap.wps.com/l/cbCaijF8JMbfRp2f","pdf",227796,"English","# CARB-X Complete Portfolio (as of 6/30/25)\n## Graduates-Therapeutics\n## Graduates-Preventatives\n## Graduates-Diagnostics\n## Active Product Pipeline (as of 6/30/25)\n## Active-Therapeutics Projects\n## Active-Preventatives Projects\n## Active-Diagnostics Projects","[{\"question\":\"How is the CARB-X content organized in the portfolio overview?\",\"answer\":\"It is organized into a complete portfolio as of 6/30/25, including graduate listings for therapeutics, preventatives, and diagnostics, followed by an active product pipeline section covering currently funded projects.\"},{\"question\":\"What development-stage information does the document provide for CARB-X products?\",\"answer\":\"For each product it records progress through stages such as feasibility, hit-to-lead, lead optimization, pre-clinical, and Phase 1, and it also indicates development-stage progress related to graduation.\"},{\"question\":\"What kinds of technical descriptors are included for therapeutics and diagnostics?\",\"answer\":\"Therapeutics entries include targets and spectrum of activity (e.g., Gram-negative activity, ESKAPE, MRSA), while diagnostics entries describe the syndrome focus and diagnostic approach steps such as verification and validation.\"}]","CARB-X Pipeline - 2025-06-30 | PDF"]