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A prior study showed that adding capecitabine maintenance after radiofrequency ablation improved 5-year overall survival (88.7% vs 69.1%) and reduced 5-year local tumor progression (22.7% vs 49.0%), despite no significant difference in progression-free survival. 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A recent article demonstrated that adding capecitabine maintenance therapy after radiofrequency ablation improved the 5-year overall survival (88.7% vs 69.1%) and reduced local tumor progression (22.7% vs 49.0%) compared with radiofrequency ablation alone. Although progression-free survival did not differ significantly between the two treatments, multivariate analysis confirmed a robust survival benefit. These findings support the use of systemic maintenance to eradicate micrometastases after locoregional control and warrant validation in prospective randomized trials.  \nKey Words: Colorectal cancer; Lung oligometastases; Radiofrequency ablation; Capecitabine; Maintenance therapy; Recurrence prevention  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Preventing the recurrence of lung oligometastases from colorectal cancer after local therapy is crucial. Recent evidence demonstrated that capecitabine maintenance after radiofrequency ablation significantly increased 5-year overall survival and reduced 5-year local tumor progression rates compared with radiofrequency ablation alone. This synergistic approach proactively targets micrometastatic disease. Despite the retrospective nature of the study, its robust results support the confirmation of systemic maintenance with local ablation in prospective randomized controlled trials.  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 28, 2025  Volume 31  Issue 48   \nGiangregorio F. Preventing CRC lung oligometastases recurrence  \nCitation: Giangregorio F. Capecitabine maintenance after radiofrequency ablation: A preventive strategy for lung oligometastases from colorectal cancer. World J Gastroenterol 2025; 31(48): 113550  \nURL: [https://www.wjgnet.com/1007-9327/full/v31/i48/113550.htm](https://www.wjgnet.com/1007-9327/full/v31/i48/113550.htm)  \nDOI: [https://dx.doi.org/10.3748/wjg.v31.i48.113550](https://dx.doi.org/10.3748/wjg.v31.i48.113550)  \nThe recent article by Li et al [1], titled “Radiofrequency ablation with or without capecitabine maintenance therapy for lung oligometastases from colorectal cancer”, was read with great interest. The study aimed to determine whether adding capecitabine maintenance therapy after radiofrequency ablation (RFA) improves outcomes for patients with lung oligometastases from colorectal canc","cbCain5uZeBeVdGn","https://ap.wps.com/l/cbCain5uZeBeVdGn","pdf",448257,"English","# Abstract\n# Key Words\n# Core Tip\n# Letter to the Editor\n## Study background and aims\n## Definitions and clinical context of oligometastatic disease","[{\"question\":\"What clinical question does the letter address?\",\"answer\":\"It focuses on whether adding capecitabine maintenance after radiofrequency ablation improves outcomes for lung oligometastases from colorectal cancer compared with radiofrequency ablation alone.\"},{\"question\":\"What outcomes reportedly improved with capecitabine maintenance?\",\"answer\":\"Compared with radiofrequency ablation alone, the referenced article reported higher 5-year overall survival and lower 5-year local tumor progression. Progression-free survival was not significantly different.\"},{\"question\":\"Why is systemic maintenance considered important after local therapy?\",\"answer\":\"The findings are interpreted as evidence that systemic maintenance may eradicate micrometastatic disease following locoregional control, warranting confirmation in prospective randomized trials.\"}]","Capecitabine maintenance after radiofrequency ablation - A preventive strategy for lung oligometastases from colorectal cancer | PDF",1790565696,18]