[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31426":3,"doc-seo-31426":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31426,1099513958607,"Jiven","https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399",8,"Research & Report","CaO2-DOX-CuMOF/PEG GSH-Responsive Chemo-Chemodynamic Anticancer Nanoplatform","Efficient chemodynamic therapy depends on intracellular H2O2 self-supply coupled with glutathione (GSH) depletion. Doxorubicin (DOX) was loaded onto CaO2 nanoparticles and then encapsulated into a Cu-based metal–organic framework (CuMOF), followed by PEG surface modification to yield the CaO2-DOX-CuMOF/PEG nanoplatform. The system is GSH-responsive: it generates endogenous oxidative stress and releases DOX. In GSH-rich cancer cells, CaO2-DOX-CuMOF/PEG disintegrates to liberate DOX and CaO2, promoting H2O2 formation and reactive oxygen species (ROS). In vitro assays on lung adenocarcinoma cells and in vivo mouse tumor models confirm superior tumor suppression versus single therapies, with broad drug-loading potential.","cbCaifRvLk7VW8Eo","https://ap.wps.com/l/cbCaifRvLk7VW8Eo","pdf",14503586,1,15,"English","en","# Introduction\n## Chemodynamic therapy via Fenton-like chemistry\n## MOFs for synergistic CT–CDT\n## Rationale for Cu-based MOFs and GSH responsiveness\n## Improving intracellular H2O2 using H2O2 generators and CaO2","[{\"question\":\"What intracellular conditions are required for efficient chemodynamic therapy?\",\"answer\":\"Efficient CDT requires self-supply of H2O2 inside cells while simultaneously depleting glutathione (GSH) to enable oxidative stress–mediated cancer killing.\"},{\"question\":\"How does the CaO2-DOX-CuMOF/PEG nanoplatform respond to GSH in cancer cells?\",\"answer\":\"GSH-rich cancer cells disintegrate CaO2-DOX-CuMOF/PEG, releasing DOX and CaO2. The freed components promote formation of H2O2, which drives reactive oxygen species (ROS) generation and oxidative stress.\"},{\"question\":\"What evidence supports the benefit of combining chemo−chemodynamic therapy in this study?\",\"answer\":\"Antiproliferative performance was assessed in vitro using lung adenocarcinoma cells via cytotoxicity, intracellular ROS generation, and mitochondrial membrane potential, and in vivo in a mice tumor model where the combined therapy outperformed individual therapies.\"}]",1779483632,38,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"cao2-dox-cumofpeg-gsh-responsive-chemo-chemodynamic-anticancer-nanoplatform","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/cao2-dox-cumofpeg-gsh-responsive-chemo-chemodynamic-anticancer-nanoplatform/31426/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-22",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What intracellular conditions are required for efficient chemodynamic therapy?","Question",{"text":73,"@type":74},"Efficient CDT requires self-supply of H2O2 inside cells while simultaneously depleting glutathione (GSH) to enable oxidative stress–mediated cancer killing.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How does the CaO2-DOX-CuMOF/PEG nanoplatform respond to GSH in cancer cells?",{"text":78,"@type":74},"GSH-rich cancer cells disintegrate CaO2-DOX-CuMOF/PEG, releasing DOX and CaO2. The freed components promote formation of H2O2, which drives reactive oxygen species (ROS) generation and oxidative stress.",{"name":80,"@type":71,"acceptedAnswer":81},"What evidence supports the benefit of combining chemo−chemodynamic therapy in this study?",{"text":82,"@type":74},"Antiproliferative performance was assessed in vitro using lung adenocarcinoma cells via cytotoxicity, intracellular ROS generation, and mitochondrial membrane potential, and in vivo in a mice tumor model where the combined therapy outperformed individual therapies.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]