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The document consolidates advances in diagnosis and treatment, translating findings into clear first-, second-, and third-line options with explicit consideration of evidence levels, clinical support, and consensus safety, tolerability, and treatment-emergent switch risk. New hierarchical rankings address acute mania, acute depression, and maintenance in bipolar I, and also cover bipolar II, specific populations, comorbidities, and safety 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is new in the CANMAT and ISBD 2018 bipolar disorder guidelines?","Question",{"text":113,"@type":114},"The guidelines introduce hierarchical rankings for first- and second-line treatments across acute mania, acute depression, and maintenance in bipolar I disorder, plus updated recommendations reflecting advances since 2005.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do the guidelines structure treatment recommendations?",{"text":118,"@type":114},"Recommendations are organized into first-, second-, and third-line options, using evidence levels, clinical support based on experience, and consensus ratings of safety, tolerability, and switch risk.",{"name":120,"@type":111,"acceptedAnswer":121},"Which bipolar disorder groups and patient populations are covered?",{"text":122,"@type":114},"Beyond bipolar I, the guidelines provide an overview and recommendations for bipolar II and include advice for specific populations such as women across reproductive stages, children and 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for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder  \nLakshmi NYatham1 | Sidney H Kennedy2  | Sagar V Parikh3 | Ayal Schaffer2  | David J Bond4 | Benicio N Frey5 | Verinder Sharma6 | Benjamin I Goldstein2  | Soham Rej7  | Serge Beaulieu7 | Martin Alda8  | Glenda MacQueen9  | Roumen V Milev10  | Arun Ravindran2 | Claire O’Donovan8 | Diane McIntosh1 | Raymond W Lam1  | Gustavo Vazquez10 | Flavio Kapczinski5 | Roger S McIntyre2 Jan Kozicky11  | Shigenobu Kanba12 | Beny Lafer13  | Trisha Suppes14 | Joseph R Calabrese15 | Eduard Vieta16  | Gin Malhi17 | Robert M Post18  | Michael Berk19  \n1Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada 2Department of Psychiatry, University of Toronto, Toronto, ON, Canada 3Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA 4Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA  \n5Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada 6Departments of Psychiatry and Obstetrics & Gynaecology, Western University, London, ON, Canada 7Department of Psychiatry, McGill University, Montreal, QC, Canada  \n8Department of Psychiatry, Dalhousie University, Halifax, NS, Canada 9Department of Psychiatry, University of Calgary, Calgary, AB, Canada  \n10Departments of Psychiatry and Psychology, Queen’s University, Kingston, ON, Canada 11School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada 12Department of Neuropsychiatry, Kyushu University, Fukuoka, Japan  \n13Department of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil  \n14Bipolar and Depression Research Program, VA Palo Alto, Department of Psychiatry & Behavioral Sciences Stanford University, Stanford, CA, USA 15Department of Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA  \n16Bipolar Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain 17Department of Psychiatry, University of Sydney, Sydney, NSW, Australia  \n18Department of Psychiatry, George Washington University, Washington, DC, USA  \n19Deakin Univeristy, IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Geelong, Vic., Australia  \n|  \nCorrespondence  \nLakshmi NYatham, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.  \n[Email: yatham@mail.ubc.ca](Email: yatham@mail.ubc.ca)  \nBipolar Disorders. 2018;20:97–[170. wileyonlinelibrary.com/journal/bdi](170. wileyonlinelibrary.com/journal/bdi) © 2018 John Wiley & Sons A/S. | 97  \nPublished by John Wiley & Sons Ltd  \nThe Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published treatment guidelines for bipolar disorder in 2005, along with international commentaries and subsequent updates in 2007, 2009, and 2013. The last two updates were published in collaboration with the International Society for Bipolar Disorders (ISBD) . These 2018 CANMAT and ISBD Bipolar Treatment Guidelines represent the significant advances in the field since the last full edition was published in 2005, including updates to diagnosis and management as well as new research into pharmacological and psychological treatments. These advances have been translated into clear and easy to use recommendations for first, second, and third-line treatments, with consideration given to levels of evidence for efficacy, clinical support based on experience, and consensus ratings of safety, tolerability, and treatment-emergent switch risk. New to these guidelines, hierarchical rankings were created for first and second-line treatments recommended for acute mania, acute depression, and maintenance treatment in bipolar I disorder. Created by considering the impact of each treatment across all ","cbCaioRQTSYudZW7","https://ap.wps.com/l/cbCaioRQTSYudZW7","pdf",3590383,74,"English","# Introduction\n## Overview of guideline advances\n## Evidence-based treatment recommendations\n## Bipolar disorder scope and populations\n## Comorbidities and safety monitoring","[{\"question\":\"What is new in the CANMAT and ISBD 2018 bipolar disorder guidelines?\",\"answer\":\"The guidelines introduce hierarchical rankings for first- and second-line treatments across acute mania, acute depression, and maintenance in bipolar I disorder, plus updated recommendations reflecting advances since 2005.\"},{\"question\":\"How do the guidelines structure treatment recommendations?\",\"answer\":\"Recommendations are organized into first-, second-, and third-line options, using evidence levels, clinical support based on experience, and consensus ratings of safety, tolerability, and switch risk.\"},{\"question\":\"Which bipolar disorder groups and patient populations are covered?\",\"answer\":\"Beyond bipolar I, the guidelines provide an overview and recommendations for bipolar II and include advice for specific populations such as women across reproductive stages, children and adolescents, and older adults.\"}]","CANMAT and ISBD 2018 Guidelines for the Management of Bipolar Disorder | PDF",1790971795,186]