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It highlights a recent report of stroke-like incidence after vaccination in a case series from Indochina where one patient had underlying breast cancer. The authors propose a possible mechanism via post-vaccination changes in blood viscosity related to increased immunoglobulin/immune elements, potentially predisposing malignancy patients to hyperviscosity and stroke-like events. Precaution is advised for patients with underlying malignancy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cancerous-patient-covid-19-vaccination-blood-viscosity-and-stroke-like-complication-letter-to-editor/384127/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cancerous-patient-covid-19-vaccination-blood-viscosity-and-stroke-like-complication-letter-to-editor/384127.png","ImageObject",300,407,{"name":92,"@type":93},"supergirl","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main concern about COVID-19 vaccination discussed in the letter?","Question",{"text":112,"@type":113},"The letter emphasizes possible adverse effects, particularly vascular complications and neurologic complications such as stroke-like events after vaccination.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why do the authors suggest stroke-like complications may occur after vaccination?",{"text":117,"@type":113},"They propose that vaccination may increase blood viscosity through elevated immune elements such as immunoglobulins, and that cancer patients may already have a higher baseline viscosity.",{"name":119,"@type":110,"acceptedAnswer":120},"What precaution is recommended for patients with underlying malignancy?",{"text":121,"@type":113},"The letter advises using COVID-19 vaccination with precaution in patients who have underlying malignancy due to the risk of hyperviscosity and related stroke-like events.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},384127,1790763924,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},962088121634,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Letter to Editor  \nCancerous Patient, COVID‑19 Vaccination, Blood Viscosity and Stroke‑Like Complication  \nDear Editor,  \nThe coronavirus disease 2019 (COVID‑19) vaccine is the hope for the management of the COVID‑19 outbreak. At present, the COVID‑19 vaccine is already in use in several countries. An important concern is the adverse effect of vaccination. There are many possible adverse effects of the COVID‑19 vaccine including vascular complication. The possible neurological complication due to the COVID‑19 vaccine is an important present consideration.[1] There are many recent reports on neurological incidences including stroke‑like complication after vaccination.  \nIn a recent local report from Indochina ([https://www](https://www). [reuters.com/world/asia](reuters.com/world/asia)‑pacific/thailand‑sticks‑with‑sinovac‑ vaccine‑after‑cases‑stroke‑like‑side‑effects‑2021‑04‑21/), a post‑COVID‑19 vaccination stroke‑like incidence occurs. A patient with underlying breast cancer is a member of all six affected cases, there is a patient with underlying breast cancer. It is questionable on the exact pathomechanism of the incidence. Indeed, a possible explanation of post‑vaccination vascular complication is the change of blood viscosity. The COVID‑19 vaccination can result in a change of blood viscosity due to an increased level of immune elements.[2] An increase in immunoglobulin is confirmed as a possible cause of increased blood viscosity.[3] A cancer patient, including the one with breast malignancy, might have a background high‑blood viscosity.[4] Therefore, after vaccination, a hyperviscosity might occur, and it might result in a stroke‑like event. For COVID‑19 vaccination, it should be used with precaution in a patient with the underlying malignancy.  \nFinancial support and sponsorship  \nNil.  \nConflicts of interest  \nThere are no conflicts of interest.  \nBeuy Joob, Viroj Wiwanitkit1  \nPrivate Academic Consultant, Bangkok, Thailand, 1Honorary Professor, Department of Community Medicine, Dr DY Patil Vidhyapeeth, Pune, Maharashtra, India  \nAddress for correspondence:  \nDr. Beuy Joob,  \nPrivate Academic Consultan, Bangkok Thailand.  \nE‑mail: [beuyjoob@hotmail.com](beuyjoob@hotmail.com)  \nReceived: 22 May 21 Revised: 25 May 2021  \nAccepted: 29 May 21 Published: 22 Jun 23  \nReferences  \n1. Lu L, Xiong W, Mu J, Zhang Q, Zhang H, Zou L, et al. The potential neurological effect of the COVID‑19 vaccines: A review. Acta Neurol Scand 2021. doi: 10. 1111/ane. 13417. Online ahead of print.  \n2. Saadat S, Tehrani ZR, Logue J, Newman M, Frieman MB, Harris AD, et al. Binding and neutralization antibody titers after a single vaccine dose in health care workers previously infected with SARS‑CoV‑2 . JAMA 2021;325:1467‑9 .  \n3. Dalakas MC. High‑dose intravenous immunoglobulin and serum viscosity: Risk of precipitating thromboembolic events. Neurology 1994;44:223‑6 .  \n4. von Tempelhoff G‑F, Schönmann N, Heilmann L, Pollow K, Hommel G. Prognostic role of plasmaviscosity in breast cancer. Clin Hemorheol Microcirc 2002;26:55‑61 .  \nHow to cite this article: Joob B, Wiwanitkit V. Cancerous patient, COVID‑19 vaccination, blood viscosity and stroke‑like complication. Int J Prev Med 2023;14:87 .  \n© 2023 International Journal of Preventive Medicine | Published by Wolters Kluwer ‑ Medknow  \n© 2023 International Journal of Preventive Medicine | Published by Wolters Kluwer-Medknow 1","cbCaivD222AKAdia","https://ap.wps.com/l/cbCaivD222AKAdia","pdf",351070,"English","# Letter to Editor\n## Adverse effects and neurologic complications\n## Proposed mechanism: blood viscosity changes\n## Clinical implication and precautions\n## Financial support, conflicts of interest, and correspondence","[{\"question\":\"What is the main concern about COVID-19 vaccination discussed in the letter?\",\"answer\":\"The letter emphasizes possible adverse effects, particularly vascular complications and neurologic complications such as stroke-like events after vaccination.\"},{\"question\":\"Why do the authors suggest stroke-like complications may occur after vaccination?\",\"answer\":\"They propose that vaccination may increase blood viscosity through elevated immune elements such as immunoglobulins, and that cancer patients may already have a higher baseline viscosity.\"},{\"question\":\"What precaution is recommended for patients with underlying malignancy?\",\"answer\":\"The letter advises using COVID-19 vaccination with precaution in patients who have underlying malignancy due to the risk of hyperviscosity and related stroke-like events.\"}]","Cancerous Patient, COVID-19 Vaccination, Blood Viscosity and Stroke-Like Complication - Letter to Editor | PDF",1790261313]