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It explains how advances in nanomaterial fabrication support a targeted therapy paradigm, including nanoparticle-assisted hyperthermia via controlled heating, magnetic nanoparticle thermoresponsiveness, and gold- or nanotube–based adjunct strategies. It also outlines how functionalized nanoparticles enable guided drug delivery and how biosensors can detect tumor biomarkers in body fluids.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cancer-treatment-approaches-within-the-frame-of-hyperthermia-drug-delivery-systems-and-biosensors-concepts-and-future-potentials/338539/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cancer-treatment-approaches-within-the-frame-of-hyperthermia-drug-delivery-systems-and-biosensors-concepts-and-future-potentials/338539.png","ImageObject",300,407,{"name":92,"@type":93},"Clementine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What traditional cancer treatment approaches are discussed, and what limitation do they share?","Question",{"text":113,"@type":114},"The review introduces traditional treatment routes such as surgery, chemotherapy, and radiotherapy. It highlights that these approaches can cause significant side effects, including fatigue, nausea, and hair loss.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does hyperthermia contribute to targeted cancer treatment in this review?",{"text":118,"@type":114},"Hyperthermia is described as a personalized approach that heats diseased tissue to destroy it via thermal effects. Magnetic nanoparticles can enhance heating and improve targeting accuracy.",{"name":120,"@type":111,"acceptedAnswer":121},"What roles do nanoparticles and biosensors play in the proposed targeted therapies?",{"text":122,"@type":114},"Functionalized nanoparticles support drug delivery by carrying therapeutic agents and releasing them at target sites. Nanoparticle-based biosensors can detect, monitor, and target tumor tissues by tracking biomarkers in body fluids.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},338539,1790078995,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1374391974564,"https://ap-avatar.wpscdn.com/avatar/14000253aa45c000a9e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779874745381141002","RSC Advances  \nREVIEW  \nCite this: RSC Adv., 2024, 14, 39297  \nReceived 28th September 2024  \nAccepted 28th November 2024 DOI: 10.1039/d4ra06992g[rsc.li/rsc-advances](rsc.li/rsc-advances)  \nCancer treatment approaches within the frame of hyperthermia, drug delivery systems, and biosensors: concepts and future potentials  \nZeinab S. Sayed,  a Eman M. Hieba,b Hany A. Batakoushy,  c Huda R. M. Rashdan,  *d Enas Ismail, ef Saeid M. Elkatlawy  g and Amir Elzwawy  *h  \nThis work presents a review of the therapeutic modalities and approaches for cancer treatment. A brief overview of the traditional treatment routes is presented in the introduction together with their reported side effects. A combination of the traditional approaches was reported to demonstrate an effective therapy until a few decades ago. With the improvement in the fabrication of nanomaterials, targeted therapy represents a novel therapeutic approach. This improvement established on nanoparticles is categorized into hyperthermia, drug delivery systems, and biosensors. Hyperthermia presentsa personalized medicine-based approach in which targeted zones are heated up until the diseased tissue is destroyed by the thermal effect. The use of magnetic nanoparticles further improved the effectiveness of hyperthermia owing to the enhanced heating action, further increasing the accuracy of the targeting process. Nanoparticle-based biosensors present a smart nanodevice that can detect, monitor, and target tumor tissues by following the biomarkers in the body fluids. Magnetic nanoparticles offer a controlled thermo-responsive device that can be manipulated by changing the magnetic field, offering a more personalized and controlled hyperthermia therapeutic modality. Similarly, gold nanoparticles offer aneffective aid in the hyperthermia treatment approach. Furthermore, carbon nanotubes and metal– organic frameworks present a cutting-edge approach to cancer treatment. A combination of functionalized nanoparticles offers a unique route for drug delivery systems, in which therapeutic agents carried by nanoparticles are guided into the human body and then released in the target spot.  \n1. Introduction  \nScienti􀀁c research always opens the doors to novel routes for improving the quality of life of human beings. Cancer is a global health issue and leading cause of poor life quality and death  \naFaculty of Applied Medical Science, Misr University for Science and Technology (MUST), Giza, Egypt  \nbChemistry and Entomology Department, Faculty of Science, Cairo University, Giza 12613, Egypt  \ncDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Menou􀀁a University, Shebin Elkom 32511, Egypt  \ndChemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Buhouth St., Dokki, Giza  \n12622, [Egypt. E-mail: Hudadawoud20@yahoo.com](Egypt. E-mail: Hudadawoud20@yahoo.com)  \neDepartment of Prosthodontics, Faculty of Dentistry, University of the Western Cape, Cape Town 7505, South Africa  \nfPhysics Department, Faculty of Science (Girl's Branch), Al Azhar University, Nasr City, 11884, Cairo, Egypt  \ngDepartment of Physics, Faculty of Science, University of Sadat City, Fi􀀁h Zone, Sadat, Egypt  \nhCeramics Department, Advanced Materials Technology and Mineral Resources Research Institute, National Research Centre (NRC), 33 El Bohouth St., Dokki, Giza, 12622, Egypt. E-mail: [elzwawy1@gmail.com](elzwawy1@gmail.com); [aa.elzwawy@nrc.sci.eg](aa.elzwawy@nrc.sci.eg)  \nworldwide. It is characterized by abnormal spread and uncontrolled growth of biological cells.1,2 Cancer is a complex and diverse disease characterized by many genetic and molecular changes that cause the unregulated growth and multiplication of cells, resulting in the rapid accumulation of tissues in theaffected areas of the body. Typically, a cell receives instructions to undergo programmed cell death and be replaced with a younger and healthier cell.3  \nT","cbCaikp2ITOM87HQ","https://ap.wps.com/l/cbCaikp2ITOM87HQ","pdf",3176636,28,"English","# Introduction\n## Traditional cancer treatment routes and side effects\n## Nanotechnology-enabled targeted approaches","[{\"question\":\"What traditional cancer treatment approaches are discussed, and what limitation do they share?\",\"answer\":\"The review introduces traditional treatment routes such as surgery, chemotherapy, and radiotherapy. It highlights that these approaches can cause significant side effects, including fatigue, nausea, and hair loss.\"},{\"question\":\"How does hyperthermia contribute to targeted cancer treatment in this review?\",\"answer\":\"Hyperthermia is described as a personalized approach that heats diseased tissue to destroy it via thermal effects. Magnetic nanoparticles can enhance heating and improve targeting accuracy.\"},{\"question\":\"What roles do nanoparticles and biosensors play in the proposed targeted therapies?\",\"answer\":\"Functionalized nanoparticles support drug delivery by carrying therapeutic agents and releasing them at target sites. Nanoparticle-based biosensors can detect, monitor, and target tumor tissues by tracking biomarkers in body fluids.\"}]","Cancer treatment approaches within the frame of hyperthermia, drug delivery systems, and biosensors: concepts and future potentials | PDF",1790024105,71]