[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-351897-105":59,"doc-detail-351897-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","cancer-risk-among-women-with-scoliosis-a-nationwide-danish-register-based-study","Cancer risk among women with scoliosis - a nationwide danish register-based study","","Adolescent Idiopathic Scoliosis (AIS) affects more than 1% of adolescents and is typically diagnosed during a vulnerable growth period, when repeated radiographs may increase cancer risk. Earlier research suggested links between scoliosis and breast cancer, but evidence was constrained by small cohorts, inadequate matched controls, and incomplete registry data. This nationwide Danish register-based cohort study evaluates cancer hazard ratios in women with scoliosis versus age-matched controls.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cancer-risk-among-women-with-scoliosis-a-nationwide-danish-register-based-study/351897/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cancer-risk-among-women-with-scoliosis-a-nationwide-danish-register-based-study/351897.png","ImageObject",300,407,{"name":92,"@type":93},"Aldword","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study aim regarding cancer risk in women with scoliosis?","Question",{"text":112,"@type":113},"To estimate the hazard ratio of cancer among women with scoliosis compared with age-matched controls using nationwide registry data.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which Danish data sources and designs were used to assess cancer outcomes?",{"text":117,"@type":113},"Cancer outcomes were obtained from the Danish National Cancer Register, using an observational cohort design with Cox regression to estimate hazard ratios.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find for breast cancer and carcinoma in situ?",{"text":121,"@type":113},"Women with scoliosis showed a significantly increased hazard ratio for carcinoma in situ (CIS) of the breast, with a non-significant trend toward increased invasive breast and gynecologic cancers.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},351897,1790181577,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},2336478940917,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Spine Deformity (2026) 14:1299–1306  \n[https://doi.org/10.1007/s43390-026-01301-5](https://doi.org/10.1007/s43390-026-01301-5)  \nCancer risk among women with scoliosis: a nationwide danish register‑based study  \nF. D. Højsager1 · L. Borch2,3 · R. Castelein4 · S. B. Christensen5 · A. Simony1,6,7  \nReceived: 29 August 2025 / Accepted: 3 February 2026 / Published online: 14 February 2026 © The Author(s) 2026  \nAbstract  \nBackground Adolescent Idiopathic Scoliosis (AIS) affects over 1% of adolescents and is often diagnosed during a sensitive developmental period, with repeated radiographs, potentially increasing cancer risk. Previous studies have suggested an association between scoliosis and breast cancer, but have been limited by small cohorts, lack of matched controls, and incomplete registry data. The aim of this study, therefore, was to assess the hazard ratio (HR) of cancer among women with scoliosis compared to age-matched controls using nationwide registry data.  \nMethods This observational cohort study included all Danish women born 1967–1977 with a scoliosis diagnosis (ICD-8 735.0/735.2 or ICD-10 DM411), and four age-matched controls per case, identified through national health registers. Cancer outcomes were obtained from the Danish National Cancer Register, and Cox regression was used to estimate HRs, with time at risk beginning at age 12.  \nResults Among 6,217 women (1,238 (20% with scoliosis), the mean follow-up time was approximately 38 years. The HR (95% CI) for any cancer was 1.06 [0.85–1.31] . For breast cancer, HR was 1.25 [0.86–1.80], while HR for carcinoma in situ (CIS) of the breast was 13.62 [3.75–49.50] . Among 12 cases of ovarian cancer, the HR was 2.91 [0.92–9.18] . This study could not, however, discriminate between idiopathic and non-idiopathic scoliosis.  \nConclusion Women with scoliosis showed a significantly increased HR for CIS of the breast, and a non-significant trend toward increased risk of invasive breast and gynecologic cancers. Findings support further investigation into genetic or developmental links between scoliosis and cancer risk.  \nKey Points • Women with scoliosis are at a higher risk of getting cancer, namely of the breast.  \n• Pregnancy did not appear to have a protective effect.  \nKeywords Scoliosis · Cancer risk · Breast cancer · Register study  \n* A. Simony [Ane.simony1@rsyd.dk](Ane.simony1@rsyd.dk)  \n1 Department of Orthopaedic Surgery and Traumatology, Hospital Lillebaelt Kolding, Kolding, Denmark  \n2 Department of Pediatric and Adolescent Medicine, Gødstrup Hospital, Herning, Denmark  \n3 NIDO|Centre for Research and Education, Gødstrup Hospital, Herning, Denmark  \n4 Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands  \n5  \n6  \n7  \nDepartment of Orthopaedic Surgery, University Hospital Rigshospitalet, Copenhagen, Denmark  \nDepartment of Regional Health Research, University of Southern Denmark, Odense, Denmark  \nDepartment of Orthopedic Surgery, The Region of Southern Denmark University Hospital, Sygehusvej 24, 6000 Kolding, Denmark  \nIntroduction  \nAdolescent Idiopathic Scoliosis (AIS) has a prevalence of 4–5% and is the most common form of scoliosis [1] . In AIS rotational stability in the spine is compromised, resulting in a three-dimensional (3D) s-shape of the spine, due to biomechanical alterations during the final growth spurt [2]. While the etiology of AIS has not yet been established, association with genetic factors have been identified [3 , 4] .  \nScoliosis is diagnosed by clinical examination, eg. Adams forward bending test [5], use of scoliometer [6], and by use of radiographs of the spine in both PosteriorAnterior (PA), and Lateral projections.  \nWhen undergoing radiographs, a dose of ionizing radiation is absorbed in the body, varying by tissue and projection [7] . The dose of radiation towards the breast in an AP projection of the spine, has been reduced drastically throughout the twentieth century, with modern techniques exposin","cbCaiefnUGLmQhy4","https://ap.wps.com/l/cbCaiefnUGLmQhy4","pdf",595728,"English","# Abstract\n# Background\n# Introduction\n# Methods\n## Data sources\n## Study population and outcomes\n## Statistical analysis\n# Results\n# Conclusion\n# Key Points\n# Keywords","[{\"question\":\"What was the study aim regarding cancer risk in women with scoliosis?\",\"answer\":\"To estimate the hazard ratio of cancer among women with scoliosis compared with age-matched controls using nationwide registry data.\"},{\"question\":\"Which Danish data sources and designs were used to assess cancer outcomes?\",\"answer\":\"Cancer outcomes were obtained from the Danish National Cancer Register, using an observational cohort design with Cox regression to estimate hazard ratios.\"},{\"question\":\"What did the study find for breast cancer and carcinoma in situ?\",\"answer\":\"Women with scoliosis showed a significantly increased hazard ratio for carcinoma in situ (CIS) of the breast, with a non-significant trend toward increased invasive breast and gynecologic cancers.\"}]","Cancer risk among women with scoliosis - a nationwide danish register-based study | PDF",1790096452]