[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-376679-105":3,"doc-detail-376679-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","cancer-prevention-with-rapamycin-research-perspective","Cancer prevention with rapamycin - Research Perspective","","Rapamycin (sirolimus) and other rapalogs (everolimus) are presented as anti-cancer and anti-aging drugs that delay cancer by targeting pre-cancerous cells directly and by slowing organism aging indirectly. Since cancer is described as an age-related disease, rapamycin is argued to delay cancer “by slowing down time.” Across dozens of murine models, rapamycin robustly prevents cancer, slows proliferation, and delays tumor progression. Evidence from organ-transplant patient contexts supports cancer-preventive effects, and proposals are made for lung cancer prevention trials in high-risk smokers, with clinical trials in warranted populations.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/cancer-prevention-with-rapamycin-research-perspective/376679/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/cancer-prevention-with-rapamycin-research-perspective/376679.png","ImageObject",300,407,{"name":42,"@type":43},"Ivy","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How does rapamycin delay cancer according to the document?","Question",{"text":63,"@type":64},"It delays cancer by directly targeting pre-cancerous cells and indirectly by slowing organism aging through effects on the mTOR pathway.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What evidence is cited for rapamycin preventing lung cancer?",{"text":68,"@type":64},"The text describes multiple murine models where rapamycin treatment after tobacco-related carcinogen exposure reduced tumor multiplicity, tumor progression, and tumor burden, including early and late intervention scenarios.",{"name":70,"@type":61,"acceptedAnswer":71},"What does the document suggest for future clinical research?",{"text":72,"@type":64},"Clinical trials in high-risk populations are warranted, including proposed use of rapamycin to prevent lung cancer in smokers and former smokers.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},376679,1790294770,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819",7,"[www.oncotarget.com](www.oncotarget.com) Oncotarget, 2023, Vol. 14, pp: 342-350  \nResearch Perspective  \nCancer prevention with rapamycin  \nMikhail V . Blagosklonny 1  \n1 Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA  \nCorrespondence to: Mikhail V. Blagosklonny, [email](email: Blagosklonny@oncotarget.com)[: Blagosklonny@oncotarget.com](email: Blagosklonny@oncotarget.com), [Blagosklonny@rapalogs.com](Blagosklonny@rapalogs.com)[ ](Blagosklonny@rapalogs.com)Keywords: chemoprevention; lung; rapamycin; aging; cancer  \nReceived: February 27, 2023 Accepted: April 06, 2023 Published: April 14, 2023  \nCopyright: © 2023 Blagosklonny. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nABSTRACT  \nRapamycin (sirolimus) and other rapalogs (everolimus) are anti-cancer and anti-aging drugs, which delay cancer by directly targeting pre-cancerous cells and, indirectly, by slowing down organism aging. Cancer is an age-related disease and, figuratively, by slowing down time (and aging), rapamycin may delay cancer. In several dozen murine models, rapamycin robustly and reproducibly prevents cancer. Rapamycin slows cell proliferation and tumor progression, thus delaying the onset of cancer in carcinogen-treated, genetically cancer-prone and normal mice. Data on the use of rapamycin and everolimus in organ-transplant patients are consistent with their cancer-preventive effects. Treatment with rapamycin was proposed to prevent lung cancer in smokers and former smokers. Clinical trials in high-risk populations are warranted.  \nINTRODUCTION  \nThe mTOR (Target of Rapamycin) pathway is involved in both cancer and aging. Furthermore, common cancers are age-related diseases, and their incidence increases exponentially with age. Rapamycin (sirolimus) and other rapalogs (temsirolimus, everolimus) may delay cancer by targeting directly pre-cancerous cells and by slowing down organism aging.  \nRapamycin delays tobacco-related and lung cancer in mice  \nIn 2007, it was demonstrated that rapamycin prevents lung cancer in mice caused by the tobaccospecific carcinogen NNK [1] . Mice were treated with NNK at the age of 6 weeks. In one of experiments, treatment with rapamycin (every-other-day) was started one week after NNK exposure. Rapamycin decreased tumor multiplicity by 90% . Phenotypic progression of tumors was slowed, tumors were smaller in size by 74% due to decreased cell proliferation. Granville et al. envisioned a clinical trial of rapamycin for smokers at high risk of lung cancer [1] .  \nSupporting these results, Patlolla et al. showed that rapamycin delayed (or prevented) development  \nof NNK-induced lung adenoma and progression from lung adenoma to adenocarcinoma in mice [2] . When treatment with rapamycin was started early (three weeks after NNK), rapamycin suppressed development of lung adenoma and adenocarcinoma [2] . For late intervention (rapamycin treatment was started 20 weeks after NNK exposure) rapamycin suppressed progression from lung adenoma to lung cancer. The authors concluded that rapamycin is effective even after dysplastic adenoma or early adenocarcinoma stages and may be useful for highrisk lung cancer people [2] .  \nYan et al. found that treatment with rapamycin for 14 weeks, beginning 12 weeks after administration of a polycyclic aromatic hydrocarbon [benzo(a)pyrene](BP), decreased lung tumor load by 84%[3] .  \nIn a model of EGFR mutant lung cancer in mice, rapamycin prevented or slowed down tumor development. Median overall survival was prolonged by more than three-fold [4] .  \nIn a different mouse model, 4-nitroquinoline-1 oxide (a surrogate of tobacco exposure) caused head and neck squamous cell carcinoma (HNSCC) . This tobacco-mimicking carcinogen leads to the appearance of preneoplastic and tumoral lesions, with 10","cbCaikGucoAbAJBC","https://ap.wps.com/l/cbCaikGucoAbAJBC","pdf",1102075,9,"English","# Abstract\n# Introduction\n## Rapamycin delays tobacco-related and lung cancer in mice\n## Rapamycin prevents cancer and extends lifespan in cancer-prone mice","[{\"question\":\"How does rapamycin delay cancer according to the document?\",\"answer\":\"It delays cancer by directly targeting pre-cancerous cells and indirectly by slowing organism aging through effects on the mTOR pathway.\"},{\"question\":\"What evidence is cited for rapamycin preventing lung cancer?\",\"answer\":\"The text describes multiple murine models where rapamycin treatment after tobacco-related carcinogen exposure reduced tumor multiplicity, tumor progression, and tumor burden, including early and late intervention scenarios.\"},{\"question\":\"What does the document suggest for future clinical research?\",\"answer\":\"Clinical trials in high-risk populations are warranted, including proposed use of rapamycin to prevent lung cancer in smokers and former smokers.\"}]","Cancer prevention with rapamycin - Research Perspective | PDF",1790220599,23,{"code":4,"msg":82,"data":100},[101,105,109,113,118,123,126,131,135,138,142],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},5,"Comic",60,"comic",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},6,"Technology",50,"technology",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":124,"slug":125},40,"healthcare",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":129,"slug":130},8,"Research & Report",30,"research-report",{"id":92,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":133,"slug":134},"Religion & Spirituality",20,"religion-spirituality",{"id":133,"doc_module":4,"doc_module_name":25,"category_name":136,"show_sort_weight":133,"slug":137},"World Cup","world-cup",{"id":139,"doc_module":4,"doc_module_name":25,"category_name":140,"show_sort_weight":139,"slug":141},10,"Lifestyle","lifestyle",{"id":143,"doc_module":4,"doc_module_name":25,"category_name":144,"show_sort_weight":114,"slug":145},19,"General","general"]