[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-367327-105":59,"doc-detail-367327-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","cancer-metastasis-molecular-mechanismsand-therapeutic-interventions","Cancer metastasis: molecular mechanismsand therapeutic interventions","","Metastatic cascade is a multi-organ, multi-step process in which cancer cells disseminate from the primary site and establish distant lesions. While the seed-and-soil framework is widely accepted, the drivers of organotropism remain unclear. Using breast cancer subtypes as a model, the study links metastatic profile of cancer cells and organ microenvironment redox status to organotropism. It connects metabolic plasticity with stemness, proposes oxidative stress as selection power, and reviews pro-oxidative strategies including chemo- and radiotherapies, physical modalities, designed nanoparticle composites, and cold atmospheric plasma.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cancer-metastasis-molecular-mechanismsand-therapeutic-interventions/367327/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cancer-metastasis-molecular-mechanismsand-therapeutic-interventions/367327.png","ImageObject",300,407,{"name":92,"@type":93},"Mia  ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What determines cancer metastasis organotropism according to the review?","Question",{"text":112,"@type":113},"The review identifies the metastatic profile of cancer cells and the redox status of the organ microenvironment as primary determinants of organotropism.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How are cancer metabolic plasticity, stemness, and oxidative stress related in the proposed mechanism?",{"text":117,"@type":113},"The authors report a positive correlation between cancer metabolic plasticity and stemness, and propose oxidative stress as the selection power that helps cancer cells succeed through the metastatic cascade.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic intervention strategy is emphasized during metastasis?",{"text":121,"@type":113},"The review proposes pro-oxidative therapeutics to ablate cancer cells by leveraging a fragile window of vulnerability during metastasis, and it surveys multiple pro-oxidative approaches and possible combinations with existing oncology treatments.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},367327,1790459837,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":41,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},687207024478,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Dai et al. Molecular Biomedicine (2025) 6:20 [https://doi.org/10.1186/s43556-025-00261-y](https://doi.org/10.1186/s43556-025-00261-y)  \nMolecular Biomedicine  \n REVIEW Open Access  \nCancer metastasis: molecular mechanismsand therapeutic interventions  \nXiaofeng Dai 1*, Ming Xi1 and Jitian Li2  \nAbstract  \nThe metastatic cascade is a complicated process where cancer cells travel across multiple organs distant from their primary site of onset. Despite the wide acceptance of the ‘seed and soil’ theory, mechanisms driving metastasis organotropism remain mystery. Using breast cancer of different subtypes as the disease model, we characterized the ‘metastatic profile of cancer cells’ and the ‘redox status of the organ microenvironment’ as the primary determinants of cancer metastasis organotropism. Mechanically, we identified a positive correlation between cancer metabolic plasticity and stemness, and proposed oxidative stress as the selection power of cancer cells succeeding the metastasis cascade. Therapeutically, we proposed the use of pro-oxidative therapeutics in ablating cancer cells taking advantages ofthis fragile moment during metastasis. We comprehensively reviewed current pro-oxidative strategies for treating cancers that cover the first line chemo-and radio-therapies, approaches relying on naturally existing power including magnetic field, electric field, light and sound, nanoparticle-based anti-cancer composites obtained through artificial design, as well as cold atmospheric plasma as an innovative pro-oxidative multi-modal modality. We discussed possible combinations of pro-oxidative approaches with existing therapeutics in oncology prior to the forecast of future research directions. This paper identified the fundamental mechanics driving metastasis organotropism and proposed intervention strategies accordingly. Insights provided here may offer clues for the design of innovative solutions that may open a new paradigm for cancer treatment.  \nKeywords Cancer, Metastasis organotropism, Onco-therapeutics, Oxidative stress, Metabolism, Cold atmospheric plasma  \nIntroduction explaining over 90% cancer-related mortality [3] .  \nUnder the long-term synergistic stimulus of various internal and external tumor-causing factors, cells loose the redox homeostasis [1, 2], leading to uncontrollable proliferation and the onset of carcinogenesis. Some transformed cells gain the metastatic features,  \n*Correspondence: Xiaofeng Dai [xiaofengteam@163.com](xiaofengteam@163.com)  \n1 National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, People’s Republic of China  \n2 Molecular Biology Lab, Henan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Henan Province, Zhengzhou 450000, China  \nMetastasis refers to the process where transformed cells are disseminated from the site of primary initiation to different location(s) of the body. A complicated cascade is involved during metastasis including, e.g., invasion, intravasation, circulation, extravasation, and colonization. The organ to which cancer cells can metastasize is non-random, with the process being known as ‘organotropism’. For example, prostate cancers preferably colonize in the bone, uveal melanomas typically relapse to the liver, and breast cancer of different subtypes favor distinct organs to metastasize that include bone, liver, brain, and lung [4] . Transformed cells need to decide ‘whether to grow or go’ [5, 6] and ‘where to go’ for sustained survival, as proliferation and migration represent two mutually exclusive  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the ","cbCaiq2u5dOvjvo5","https://ap.wps.com/l/cbCaiq2u5dOvjvo5","pdf",3766616,"English","# Abstract\n# Introduction\n## Metastasis and organotropism","[{\"question\":\"What determines cancer metastasis organotropism according to the review?\",\"answer\":\"The review identifies the metastatic profile of cancer cells and the redox status of the organ microenvironment as primary determinants of organotropism.\"},{\"question\":\"How are cancer metabolic plasticity, stemness, and oxidative stress related in the proposed mechanism?\",\"answer\":\"The authors report a positive correlation between cancer metabolic plasticity and stemness, and propose oxidative stress as the selection power that helps cancer cells succeed through the metastatic cascade.\"},{\"question\":\"What therapeutic intervention strategy is emphasized during metastasis?\",\"answer\":\"The review proposes pro-oxidative therapeutics to ablate cancer cells by leveraging a fragile window of vulnerability during metastasis, and it surveys multiple pro-oxidative approaches and possible combinations with existing oncology treatments.\"}]","Cancer metastasis: molecular mechanismsand therapeutic interventions | PDF",1790170289,76]