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Age-specific and age-standardised incidence rates with 95% confidence intervals are reported, alongside sex ratios and metastatic proportions at diagnosis.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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RT  \nCancer incidence and stage at diagnosis in children and adolescents in the Community of Madrid, 2015–2018  \nRaquel López-González1,2  | David Parra-Blázquez2  | Daniel Moñino3 | Candela Pino-Rosón1,2  | Marina Pollán4,5  | Nuria Aragonés2,5   \n1Universidad Autónoma, Madrid, Spain 2Cancer Surveillance and Registry Unit, General Directorate of Public Health, Madrid Health Department, Madrid, Spain 3 Primary Care Department, Madrid Health Department, Madrid, Spain  \n4Carlos III Health Institute, Madrid, Spain 5Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain  \nCorrespondence  \nNuria Aragonés, Cancer Surveillance and Registry Unit, General Directorate of Public Health, Madrid Health Department, Madrid, Spain.  \nEmail: [registro.cancer@salud. madrid.org](registro.cancer@salud. madrid.org)  \nFunding information  \nEuropean Union; Instituto de Salud Carlos III  \nAbstract  \nBackground: Cancer is the leading cause of death in children aged 1–14 and the second in 15-19-year-old adolescents in Spain. The Paediatric Population-Based Cancer Registry of the Community of Madrid was created to monitor its incidence and survival.  \nObjectives: This study presents the incidence of childhood and adolescent cancer (0–19 years) in Madrid at a population level by sex, age group, type of tumour and stage at diagnosis.  \nMethods: This study was a retrospective analysis of the total number of cases registered in the Paediatric Population-Based Cancer Registry of the Community of Madrid. The registry employs passive and active case finding: by cross-referencing hospital discharge data, primary healthcare data, mortality data and administrative information; and by validation of all potential incident cases through a review of electronic medical charts. All new diagnoses of malignant neoplasms, non-malignant neoplasms of the Central Nervous System, and uncertain and in situ neoplasms of the bladder, identified in 2015–2018 in individuals under age 20 residing in Madrid, were included. Patient information was collected along with tumour characteristics, including stage at diagnosis according to the Toronto Childhood Cancer Stage Guidelines. Age-specific and age-standardised incidence rates were computed with 95% confidence intervals (CI) .  \nResults: A total of 1002 tumours were registered in 5,269,524 person-years, yielding an age-standardised rate of 192.7 (95% CI 184. 3, 201.4) cases per million personyears. Male/female rate ratio was 1.1. The most common cancers across all ages comprised CNS tumours, leukaemias and lymphomas (primarily Hodgkin): 45.5 (95% CI 39.9, 51.7), 41.1 (95% CI 35.7, 47. 1) and 35.8 (95% CI 30.9, 41. 3) cases per million person-years, respectively. The proportion of metastatic tumours at diagnosis was similar for ages 0–14 (18 . 6%) and 15–19 (18 .7%) .  \nConclusions: This study provides a comprehensive understanding of childhood and adolescent cancer incidence in Madrid. The registry provides high-quality data and consolidates epidemiological surveillance of cancer in the region.  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.  \n© 2024 The Author(s) . Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd.  \nK E Y WO R D S  \nadolescent cancer, childhood cancer, incidence, Paediatric cancer, population-based cancer registry, Toronto paediatric cancer stage guidelines  \n1 | BACKGROUND  \nCancer in children and adolescents differs biologically from cancer in adults, representing 1 .4% of global cancer cases.1 Despite this low percentage, it ranks as the leading cause of death in children aged 1–14 and the second leading cause in 15-19-year-old adolescents in Spain.2  \nThe World Health Organi","cbCaiogQTvaHKgk7","https://ap.wps.com/l/cbCaiogQTvaHKgk7","pdf",625475,11,"English","# Abstract\n## Background\n## Objectives\n## Methods\n## Results\n## Conclusions\n# Background\n# Methods\n## Study design","[{\"question\":\"What cancer types and age range are included in the Madrid 2015–2018 analysis?\",\"answer\":\"The study includes individuals under 20 residing in Madrid and covers malignant neoplasms, specified non-malignant central nervous system tumours, and certain uncertain/in situ bladder neoplasms diagnosed between 2015 and 2018.\"},{\"question\":\"How does the Paediatric Population-Based Cancer Registry identify and validate cases?\",\"answer\":\"It combines passive and active case-finding by linking hospital discharge, primary healthcare, mortality, and administrative information, then validates potential incident cases through retrospective review of electronic medical charts.\"},{\"question\":\"What stage framework is used to classify tumours at diagnosis?\",\"answer\":\"Tumour stage at diagnosis follows the Toronto Childhood Cancer Stage Guidelines, enabling reporting of stage distribution, including metastatic proportions, by age group.\"}]","Cancer incidence and stage at diagnosis in children and adolescents in the Community of Madrid, 2015–2018 | PDF",1789995035,28]