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The manuscript unites multidisciplinary experts and patient perspectives to examine biological, clinical, and systemic barriers that hinder progress. It emphasizes gaps from delayed detection, overlapping pregnancy symptoms, limited access to evidence-based guidance, and the historical exclusion of pregnant patients from trials, outlining urgent unanswered questions to guide future research.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cancer-during-pregnancy-navigating-clinical-and-research-challenges/349211/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cancer-during-pregnancy-navigating-clinical-and-research-challenges/349211.png","ImageObject",300,407,{"name":92,"@type":93},"Pentious","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is cancer during pregnancy considered underexplored?","Question",{"text":112,"@type":113},"It is increasingly common but remains underexplored in oncology, limiting progress in timely diagnosis, safe treatment, and informed decision-making.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What barriers limit understanding and management of cancer during pregnancy?",{"text":117,"@type":113},"Key barriers include unique biological and clinical factors, systemic obstacles, delayed detection, overlapping pregnancy symptoms, limited access to evidence-based guidance, and the historical exclusion of pregnant patients from clinical trials.",{"name":119,"@type":110,"acceptedAnswer":120},"How does the perspective aim to advance future research and care?",{"text":121,"@type":113},"By defining urgent unanswered questions, it seeks to guide efforts to improve early detection, optimize treatment strategies that protect both parent and fetus, and expand preclinical models, registries, and patient-centered data resources.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},349211,1790417241,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374404730887,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Perspective  \nCancer During Pregnancy: Navigating Clinical and Research Challenges  \nMackenzie K. Callaway 1,†, Lizelle Comfort 2,†, Dhivyaa Anandan 1,3, Ruby Sharma 4, Narjust Florez 5, Traci R. Lyons 6,7, Doris Germain 8, Kathleen R. Cho 9, Burton L. Rochelson 2, Clarissa Bonanno 2,  \nKutluk Oktay 10,11, Sudarshana Roychoudhury 12, Eileen O’donnell 4, Richard Barakat 4, Joanne Marquardt 13, Diana W. Bianchi 14,15, Elyce Cardonick 16, Larry Norton 17, Ann H. Partridge 5, Susan M. Domchek 18,19, Virginia F. Borges 6,7, Frédéric Amant 20,21,22 and Camila O. Dos Santos 1, *  \nReceived: 3 March 2026  \nRevised: 14 April 2026  \nAccepted: 8 May 2026  \nPublished: 19 May 2026  \nCopyright: © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA;  \n[callaway@cshl.edu](callaway@cshl.edu) (M.K.C.); [anandan@cshl.edu](anandan@cshl.edu) (D.A.)  \n2 Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Northwell Health and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, New Hyde Park, NY 11042, USA; [lcomfort@northwell.edu](lcomfort@northwell.edu) (L.C.); [brochels@northwell.edu](brochels@northwell.edu) (B.L.R.); [cbonanno@northwell.edu](cbonanno@northwell.edu) (C.B.)  \n3 Stony Brook Medical Scientist Training Program, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11790, USA  \n4 Northwell Health Cancer Institute, 1111 Marcus Avenue, New Hyde Park, NY 11042, USA; [rsharma5@northwell.edu](rsharma5@northwell.edu) (R.S.); [eodonnell1@northwell.edu](eodonnell1@northwell.edu) (E.O.); [rbarakat@northwell.edu](rbarakat@northwell.edu) (R.B.)  \n5 Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA;  \nnarjust_florez@dfci.harvard.edu (N.F.); ann_partridge@dfci.harvard.edu (A.H.P.)  \n6 Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; [traci.lyons@cuanschutz.edu](traci.lyons@cuanschutz.edu) (T.R.L.); [virginia.borges@cuanschutz.edu](virginia.borges@cuanschutz.edu) (V.F.B.)  \n7 University of Colorado Cancer Center Young Women’s Breast Cancer Translational Program, Aurora, CO 80045, USA  \n8 Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; [doris.germain@mssm.edu](doris.germain@mssm.edu)  \n9 Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA; [kathcho@med.umich.edu](kathcho@med.umich.edu)  \n10 Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USA; [kutluk.oktay@yale.edu](kutluk.oktay@yale.edu)  \n11 Innovation Institute for Fertility Preservation, New York, NY 10016, USA  \n12 Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Greenvale, NY 11549, USA; [sroychoudh@northwell.edu](sroychoudh@northwell.edu)  \n[13](13 Babylon Breast Cancer Coalition)[ Babylon Breast Cancer Coalition](13 Babylon Breast Cancer Coalition), [218N Wellwood Ave Suite \\#2](218N Wellwood Ave Suite #2), [Lindenhurst](Lindenhurst), [NY 11757](NY 11757), [USA](USA); [jtmarquardt@aol.com](jtmarquardt@aol.com)  \n14 Prenatal Genomics and Therapy Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, 35A Convent Drive, Bethesda, MD 20892, USA; [diana.bianchi@nih.gov](diana.bianchi@nih.gov)  \n15 Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA  \n16 Department of Obstetrics and Gynecology, Cooper University Health Care, Camden, NJ 08103, USA; [cardonick-elyce@cooperhealth.edu](cardonick-elyce@coo","cbCaivV5xGz8OF2d","https://ap.wps.com/l/cbCaivV5xGz8OF2d","pdf",319372,18,"English","# Simple Summary\n## Clinical barriers and delayed detection\n## Research gaps in trials and evidence-based guidance\n## Unanswered questions and future directions","[{\"question\":\"Why is cancer during pregnancy considered underexplored?\",\"answer\":\"It is increasingly common but remains underexplored in oncology, limiting progress in timely diagnosis, safe treatment, and informed decision-making.\"},{\"question\":\"What barriers limit understanding and management of cancer during pregnancy?\",\"answer\":\"Key barriers include unique biological and clinical factors, systemic obstacles, delayed detection, overlapping pregnancy symptoms, limited access to evidence-based guidance, and the historical exclusion of pregnant patients from clinical trials.\"},{\"question\":\"How does the perspective aim to advance future research and care?\",\"answer\":\"By defining urgent unanswered questions, it seeks to guide efforts to improve early detection, optimize treatment strategies that protect both parent and fetus, and expand preclinical models, registries, and patient-centered data resources.\"}]","Cancer During Pregnancy - Navigating Clinical and Research Challenges | PDF",1790082233,45]