[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-383134-105":59,"doc-detail-383134-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","cancer-chemoprevention-with-pv-1-a-novel-prunella-vulgaris-containing-herbal-mixture-that-remodels-the-tumor-immune-microenvironment-in-mice","Cancer chemoprevention with PV-1, a novel Prunella vulgaris-containing herbal mixture that remodels the tumor immune microenvironment in mice","","Cancer chemoprevention with PV-1 evaluates a novel herbal mixture built from Prunella vulgaris and three additional botanicals for immune and tumor-modulating effects in mice. PV-1 showed no toxicity in a dose-escalation study in A/J mice and suppressed lung tumor development in chemically induced lung cancer models. In C57BL/6 mice, PV-1 also hindered induction of oral squamous cell carcinomas. Flow cytometry indicated increased CD8+ tumor-infiltrating lymphocytes and enhanced granzyme B, TNF-α, and IFN-γ production by CD8+ TILs, along with reduced g-MDSCs and improved anti-PD-1 therapeutic activity.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cancer-chemoprevention-with-pv-1-a-novel-prunella-vulgaris-containing-herbal-mixture-that-remodels-the-tumor-immune-microenvironment-in-mice/383134/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cancer-chemoprevention-with-pv-1-a-novel-prunella-vulgaris-containing-herbal-mixture-that-remodels-the-tumor-immune-microenvironment-in-mice/383134.png","ImageObject",300,407,{"name":92,"@type":93},"Anna Hans","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is PV-1, and how was it designed?","Question",{"text":113,"@type":114},"PV-1 is a novel lung cancer prevention formula combining Prunella vulgaris with three other Chinese herbs: Polygonum bistorta, Sonchus brachyotus, and Dictamnus dasycarpus.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Did PV-1 show toxicity in the animal studies?",{"text":118,"@type":114},"PV-1 exhibited no toxicity in a dose escalation study in A/J mice.",{"name":120,"@type":111,"acceptedAnswer":121},"How does PV-1 influence the tumor immune microenvironment?",{"text":122,"@type":114},"PV-1 increased CD8+ tumor-infiltrating lymphocytes and enhanced CD8+ TIL production of granzyme B, TNF-α, and IFN-γ, while suppressing g-MDSCs and improving the anti-cancer activity of anti-PD-1 immunotherapy.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},383134,1790318996,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},5909892332657,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","TYPE Original Research PUBLISHED 24 November 2023 DOI 10.3389/fimmu.2023.1196434  \nOPEN ACCESS  \nEDITED BY  \nErika Adriana Eksioglu,  \nMoffitt Cancer Center, United States  \nREVIEWED BY Junxuan Lu,  \nThe Pennsylvania State University, United States  \nJen-Tsung Chen,  \nNational University of Kaohsiung, Taiwan Robert David Hoffman,  \nZhejiang Chinese Medical University, China  \n*CORRESPONDENCE Ming You  \n [myou@houstonmethodist.org](myou@houstonmethodist.org)  \nRECEIVED 05 April 2023  \nACCEPTED 20 July 2023  \nPUBLISHED 24 November 2023  \nCITATION  \nZhang Q, Chen X, Palen K, Johnson B, Bui D, Xiong D, Pan J, Hu M, Wang Y and You M (2023) Cancer chemoprevention with PV-1, a novel Prunella vulgariscontaining herbal mixture that remodels the tumor immune microenvironment in mice.  \nFront. Immunol. 14:1196434 .  \ndoi: 10.3389/fimmu.2023.1196434  \nCOPYRIGHT  \n© 2023 Zhang, Chen, Palen, Johnson, Bui, Xiong, Pan, Hu, Wang and You. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nCancer chemoprevention with PV-1, a novel Prunella vulgariscontaining herbal mixture that remodels the tumor immune microenvironment in mice  \nQi Zhang 1, Xu Chen 2, Katie Palen 3, Bryon Johnson 3, Dinh Bui 4, Donghai Xiong 1, Jing Pan 1, Ming Hu 4, Yian Wang 1  \nand Ming You 1*  \n1Center for Cancer Prevention, Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX, United States, 2 Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States, 3 Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States, 4College of Pharmacy, University of Houston, Houston, TX, United States  \nThe herb Prunella vulgaris has shown significant immune-stimulatory and antiinflammatory effects in mouse models. Here, the effects of a novel Prunella vulgaris-containing herbal mixture, PV-1, were examined in several mouse models for cancer, including chemically induced models of lung and oral cancers as well as syngraft models for lung cancer and melanoma. PV-1, consisting of extracts from Prunella vulgaris, Polygonum bistorta, Sonchusbrachyotus and Dictamnus dasycarpus, exhibited no toxicity in a dose escalation study in A/J mice. PV-1 significantly inhibited mouse lung tumor development induced by the lung carcinogens vinyl carbamate and benzo[a] pyrene. PV-1 also hindered the induction of oral squamous cell carcinomas in C57BL/6 mice caused by 4-nitroquinoline-1-oxide. Flow cytometry analysis showed that PV-1 increased the numbers of CD8+ tumor-infiltrating lymphocytes (TILs) and increased the production of granzyme B, TNF-a, and IFN-g by CD8+ TILs. PV-1 also suppressed granulocytic myeloid-derived suppressor cell numbers (g-MDSCs) and improved the anti‐cancer activity of anti-PD‐1 immunotherapy. These results indicate that PV-1 remodels the tumor immune microenvironment by selectively inhibiting g‐MDSCs and increasing CD8+ TILs within tumors, resulting in decreased immune suppression and enhanced cancer chemopreventive efficacy.  \nKEYWORDS  \nPV-1, che mo prevention, lung cancer, oral cancer, melanoma, tumor immune microenvironment  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \nIntroduction  \nPrunella vulgaris (PV) is a perennail wildflower frequently used in traditional Chinese medicine (TCM) . PV extracts can have multiple biological activities, including anti-inflammatory, antibacterial, and anti-cancer effects (1) . PV is rich in phenolic acids,flavonoids, coumarins, triterpenes, volatile oil, and polysaccharides (2, 3) . Furthermore, PV extracts have been reported to have chemopre","cbCaikGbVxaiP41K","https://ap.wps.com/l/cbCaikGbVxaiP41K","pdf",1561240,"English","# Introduction\n## Background of Prunella vulgaris and its reported bioactivities\n## Yin-Yang theory and TCM rationale for lung tumor prevention\n## Development of the PV-1 formula and constituent herbs","[{\"question\":\"What is PV-1, and how was it designed?\",\"answer\":\"PV-1 is a novel lung cancer prevention formula combining Prunella vulgaris with three other Chinese herbs: Polygonum bistorta, Sonchus brachyotus, and Dictamnus dasycarpus.\"},{\"question\":\"Did PV-1 show toxicity in the animal studies?\",\"answer\":\"PV-1 exhibited no toxicity in a dose escalation study in A/J mice.\"},{\"question\":\"How does PV-1 influence the tumor immune microenvironment?\",\"answer\":\"PV-1 increased CD8+ tumor-infiltrating lymphocytes and enhanced CD8+ TIL production of granzyme B, TNF-α, and IFN-γ, while suppressing g-MDSCs and improving the anti-cancer activity of anti-PD-1 immunotherapy.\"}]","Cancer chemoprevention with PV-1, a novel Prunella vulgaris-containing herbal mixture that remodels the tumor immune microenvironment in mice | PDF",1790254421,23]