[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-336317-105":59,"doc-detail-336317-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","cancer-biotherapy-review-and-prospect","Cancer biotherapy: review and prospect","","Malignant tumors threaten quality of human life, and their prevalence in China is steadily increasing. While clinical practice relies on surgery, radiotherapy, and pharmaceutical therapy alone or in combination, these approaches often fail to eliminate tumor cells completely, leading to metastasis and recurrence. Tumor biotherapy is presented as a safer, more effective fourth strategy with minimal adverse effects. The paper reviews recent biological treatments, including gene therapy, tumor vaccines, monoclonal antibodies, cancer stem cell therapy, cytokine therapy, and adoptive cellular immunotherapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cancer-biotherapy-review-and-prospect/336317/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cancer-biotherapy-review-and-prospect/336317.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are current treatments for malignant tumors often insufficient?","Question",{"text":112,"@type":113},"Even with surgery, radiotherapy, and pharmaceutical therapy, modalities frequently cannot fully eradicate malignant tumor cells, resulting in metastasis and recurrence.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is tumor biotherapy and why is it considered promising?",{"text":117,"@type":113},"Tumor biotherapy is described as an encouraging fourth approach that helps prevent and manage malignant tumors with safety, efficacy, and minimal adverse effects.",{"name":119,"@type":110,"acceptedAnswer":120},"Which tumor biotherapy methods are covered in the review?",{"text":121,"@type":113},"The review discusses gene therapy, tumor vaccines, monoclonal antibody therapy, cancer stem cell therapy, cytokine therapy, and adoptive cellular immunotherapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},336317,1790331832,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","Clinical and Experimental Medicine (2024) 24:114 [https://doi.org/10.1007/s10238-024-01376-2](https://doi.org/10.1007/s10238-024-01376-2)  \nCancer biotherapy: review and prospect  \nQi Liu1,2 · Hu Ma1,2  \nReceived: 2 February 2024 / Accepted: 13 May 2024 / Published online: 27 May 2024 © The Author(s) 2024  \nAbstract  \nMalignant tumors pose a grave threat to the quality of human life. The prevalence of malignant tumors in China is steadily rising. Presently, clinical interventions encompass surgery, radiotherapy, and pharmaceutical therapy in isolation or combination. Nonetheless, these modalities fail to completely eradicate malignant tumor cells, frequently leading to metastasis and recurrence. Conversely, tumor biotherapy has emerged as an encouraging fourth approach in preventing and managing malignant tumors owing to its safety, efficacy, and minimal adverse effects. Currently, a range of tumor biotherapy techniques are employed, including gene therapy, tumor vaccines, monoclonal antibody therapy, cancer stem cell therapy, cytokine therapy, and adoptive cellular immunotherapy. This study aims to comprehensively review the latest developments in biological treatments for malignant tumors.  \nKeywords Tumors · Biological therapy · Immunotherapy · Gene therapy  \nIntroduction  \nAs a result of rapid socio-economic development and environmental changes, malignant tumors have emerged as a significant health concern, posing a grave threat to human life. The overall prevalence of malignant tumors is on the rise in our country. Recent statistics predict an estimated 1.95 million new cases and 0.60 million deaths from malignant tumors in the United States by 2023 [1]. Notably, lung cancer (LUNG), colorectal cancer (COAD), gastric cancer (GC), hepatocellular carcinoma (HCC), and breast cancer (BRCA) are the most common and contribute prominently to the escalating mortality rates. Malignant tumors possess an inherent characteristic of unrestricted proliferation, making their complete eradication through surgery, radiotherapy (RT), or chemotherapy alone highly challenging. Interestingly, tumor biotherapy had already entered clinical practice a century ago (Fig.1) [2–13] . However, limited advancements in biotechnology hindered its widespread clinical application back then. Subsequently, with extensive research  \n* Hu Ma[mahuab@163.com](mahuab@163.com)  \n1 Zunyi Medical University, Zunyi, Guizhou 563000, China  \n2 Department of Thoracic Oncology, The Second Affiliated Hospital of Zunyi Medical University, Guizhou 56300, Zunyi, China  \non the molecular mechanisms underlying tumor occurrence and development and the rapid progress in biotechnology, tumor biotherapy has emerged as a novel and fourth primary treatment modality, complementing surgery, RT, and chemotherapy [14]. Tumor biotherapy utilizes biological engineering techniques and agents to cultivate and amplify immune cells harvested from patients. Subsequently, these bolstered cells are reintroduced into patients' bodies to stimulate and enhance their own immune system, ultimately fostering the fight against malignant tumors [15] . Presently, biotherapy for malignant tumors encompasses diverse methodologies, including genes therapy, tumor vaccines, monoclonal antibodies (mAbs) therapy, stem cells (SC) therapy, cytokines therapy, and adoptive cell therapies (ACT) (Fig.2) . This article aims to provide a comprehensive overview of the recent research advancements in biotherapy for specific malignant tumors.  \nGenes therapy  \nGene therapy is a biomedical technology that involves the insertion of normal or therapeutic exogenous genes into target cells. The aim is to repair or replace defective genes in these cells, ultimately treating diseases. Current tumor gene therapy includes tumor suppressor gene therapy, suicide gene therapy and oncolytic virus gene therapy (Fig.3) .  \nFig. 1 A hundred years of development of cancer biotherapy  \nFig. 2 Main treatment mode of tumor biology. A Biothe","cbCaijJT8HJxWvw8","https://ap.wps.com/l/cbCaijJT8HJxWvw8","pdf",1616574,"English","# Abstract\n# Introduction\n# Genes therapy\n## Tumor suppressor genes therapy","[{\"question\":\"Why are current treatments for malignant tumors often insufficient?\",\"answer\":\"Even with surgery, radiotherapy, and pharmaceutical therapy, modalities frequently cannot fully eradicate malignant tumor cells, resulting in metastasis and recurrence.\"},{\"question\":\"What is tumor biotherapy and why is it considered promising?\",\"answer\":\"Tumor biotherapy is described as an encouraging fourth approach that helps prevent and manage malignant tumors with safety, efficacy, and minimal adverse effects.\"},{\"question\":\"Which tumor biotherapy methods are covered in the review?\",\"answer\":\"The review discusses gene therapy, tumor vaccines, monoclonal antibody therapy, cancer stem cell therapy, cytokine therapy, and adoptive cellular immunotherapy.\"}]","Cancer biotherapy: review and prospect | PDF",1790014505,48]