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This single-center retrospective propensitymatched cohort study used electronic health records from January 2020 to December 2024, stratifying HFpEF patients by biopsy-proven or imaging-confirmed cancer history and evaluating mortality, HF hospitalization, and MACE, plus functional and health-status changes.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/cancer-and-the-risk-of-death-heart-failure-hospitalization-and-major-adverse-cardiovascular-events-in-hfpef-a-propensitymatched-cohort-study/352494/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/cancer-and-the-risk-of-death-heart-failure-hospitalization-and-major-adverse-cardiovascular-events-in-hfpef-a-propensitymatched-cohort-study/352494.png","ImageObject",300,407,{"name":42,"@type":43},"River Wang","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the study purpose regarding cancer and HFpEF outcomes?","Question",{"text":63,"@type":64},"To determine whether cancer independently increases mortality, heart-failure hospitalization, and major adverse cardiovascular events (MACE) in patients with HFpEF.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were cancer and HFpEF patients grouped for analysis?",{"text":68,"@type":64},"Adults with HFpEF were stratified by a history of biopsy-proven or imaging-confirmed cancer, then compared using propensity-score matching (1:1 nearest-neighbor, caliper 0.2).",{"name":70,"@type":61,"acceptedAnswer":71},"Which outcomes did the study evaluate, and what did it find in the matched cohort?",{"text":72,"@type":64},"Primary outcomes were all-cause mortality, HF hospitalization (HFH), and MACE, with secondary outcomes including NYHA class change and health status. In the matched cohort, cumulative incidences at 48 months were higher for cancer versus non-cancer in all primary outcomes, and cancer remained independently associated with HFH in multivariable Cox models.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},352494,1790258639,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","TYPE Original Research PUBLISHED 13 February 2026 DOI 10.3389/fonc.2026.1728009  \nOPEN ACCESS  \nEDITED BY  \nMatthew Yousefzadeh,  \nColumbia University, United States  \nREVIEWED BY  \nMatthew Yousefzadeh,  \nColumbia University, United States Ibrahim Abdelgawad,  \nAbbVie, United States  \n*CORRESPONDENCE  \nJianhua Jiao  \n [mnqw1230901@163.com](mnqw1230901@163.com)  \n†These authors share first authorship  \nRECEIVED 19 October 2025  \nREVISED 27 November 2025  \nACCEPTED 12 January 2026  \nPUBLISHED 13 February 2026  \nCITATION  \nLi C, Meng F, Xie Y, Li P and Jiao J (2026) Cancer and the risk of death, heart-failure hospitalization, and major adverse cardiovascular events in HFpEF: a propensitymatched cohort study.  \nFront. Oncol. 16:1728009 .  \ndoi: 10.3389/fonc.2026.1728009  \nCOPYRIGHT  \n© 2026 Li, Meng, Xie, Li and Jiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nCancer and the risk of death, heart-failure hospitalization, and major adverse cardiovascular events in HFpEF: a propensitymatched cohort study  \nChunling Li 1†, Fanhua Meng 1†, Yunbo Xie 2, Peng Li 3 and Jianhua Jiao 1*  \n1Geriatric Department, Zhangjiakou First Hospital, Zhangjiakou, China, 2Cardiology Department, Zhangjiakou First Hospital, Zhangjiakou, China, 3 Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, National Center of Gerontology, Beijing, China  \nBackground: Cancer and heart failure with preserved ejection fraction (HFpEF) frequently coexist in older adults and may share pathobiology, yet the independent effect of cancer on clinical outcomes in HFpEF remains uncertain. Methods: We performed a single-center, retrospective cohort study using electronic health records from January 2020 through December 2024 . Adults with HFpEF were stratified by a history of biopsy-proven or imaging-confirmed cancer. Primary outcomes were all-cause mortality, heart-failure hospitalization (HFH), and a composite of major adverse cardiovascular events (MACE: nonfatal myocardial infarction, HF rehospitalization, or arrhythmia requiring intervention) . Secondary outcomes included change in New York Heart Association (NYHA) class, health status by Kansas City Cardiomyopathy Questionnaire (KCCQ), cause-specific mortality, and HFpEF-related health-care utilization. Propensityscore matching (PSM; 1:1 nearest-neighbor, caliper 0.2) balanced key covariates (age, sex, comorbidities, renal function, biomarkers, NYHA class, and LVEF) . Time-to-event analyses used Kaplan–Meier methods and Cox proportionalhazards models with Greenwood 95% confidence bands and Schoenfeld diagnostics; prespecified subgroup analyses evaluated age, diabetes, chronic kidney disease (CKD), and NT-proBNP strata.  \nResults: Of 403 eligible patients (cancer, 174; non-cancer, 229; median followup, 36 months), PSM yielded 306 patients (153 per group) with excellent covariate balance. In the matched cohort, cumulative incidences at 48 months were higher with cancer than without for all-cause mortality (31 .4% vs. 15. 0%; log-rank P = 0. 012), HFH (36 .7% vs. 22. 9%; P = 0 . 031), and MACE (43 . 1% vs. 32.7%; P = 0 . 050) . In multivariable Cox models for HFH, cancer remained independently associated with risk across progressive adjustments: age-adjusted hazard ratio (HR) 1.42 (95% CI, 1.08–1.87), age-and-sex adjusted HR 1.40 (1.06–1.85), and fully adjusted HR 1 .38 (1 .02–1. 87) after additional control for diabetes, CKD, and NT-proBNP. Subgroup analyses showed directionally consistent cancer effects without significant interactions (all P for interaction ≥0","cbCaieNFgCTzFXlu","https://ap.wps.com/l/cbCaieNFgCTzFXlu","pdf",2674640,13,"English","# Background\n# Methods\n## Study design and outcomes\n## Propensity-score matching and statistical analysis\n# Results\n## Matched cohort findings\n## Secondary outcomes and subgroup analyses\n# Conclusions\n# Keywords","[{\"question\":\"What was the study purpose regarding cancer and HFpEF outcomes?\",\"answer\":\"To determine whether cancer independently increases mortality, heart-failure hospitalization, and major adverse cardiovascular events (MACE) in patients with HFpEF.\"},{\"question\":\"How were cancer and HFpEF patients grouped for analysis?\",\"answer\":\"Adults with HFpEF were stratified by a history of biopsy-proven or imaging-confirmed cancer, then compared using propensity-score matching (1:1 nearest-neighbor, caliper 0.2).\"},{\"question\":\"Which outcomes did the study evaluate, and what did it find in the matched cohort?\",\"answer\":\"Primary outcomes were all-cause mortality, HF hospitalization (HFH), and MACE, with secondary outcomes including NYHA class change and health status. In the matched cohort, cumulative incidences at 48 months were higher for cancer versus non-cancer in all primary outcomes, and cancer remained independently associated with HFH in multivariable Cox models.\"}]","Cancer and the risk of death, heart-failure hospitalization, and major adverse cardiovascular events in HFpEF - a propensitymatched cohort study | PDF",1790099909,33]