[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-372511-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-372511-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","cancer-and-neurotransmitter-receptors-review-article","Cancer and neurotransmitter receptors - review article","","Growing evidence indicates that the nervous system is essential for tumor development and metastasis. Understanding signaling crosstalk between neural pathways and cancer progression has become a key research direction. This review highlights how neurotransmitter receptors are expressed in cancer cells and regulate initiation and progression through multiple mechanisms, including effects on growth, apoptosis, angiogenesis, metastasis, drug resistance, and neural–cancer interaction formation. It also covers roles in metabolic control and tumor microenvironment remodeling, suggesting receptor modulators as potential therapeutic targets.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/cancer-and-neurotransmitter-receptors-review-article/372511/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/cancer-and-neurotransmitter-receptors-review-article/372511.png","ImageObject",300,407,{"name":42,"@type":43},"Rizky","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What role does the nervous system play in cancer progression?","Question",{"text":63,"@type":64},"The nervous system contributes centrally to cancer pathogenesis by influencing tumor development and metastasis, including both systemic effects and local remodeling of tissue innervation.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do neurotransmitter receptors influence cancer?",{"text":68,"@type":64},"Neurotransmitter receptors are widely expressed in cancer cells and regulate cancer initiation and progression through diverse mechanisms affecting growth, apoptosis, angiogenesis, metastasis, and drug resistance.",{"name":70,"@type":61,"acceptedAnswer":71},"Are neurotransmitter receptors potential targets for cancer treatment?",{"text":72,"@type":64},"Basic and clinical studies suggest neurotransmitter receptors may be potential therapeutic targets, with agonists or antagonists identified for controlling tumor growth and metastasis.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},372511,1791412358,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":127,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},962085564807,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Review Article  \nCancer and neurotransmitter receptors  \nXiaoqiang Wang1,2, Muyan Shi1,2, Jie Tian1,2, Weifeng Yu1,2,3  \n1Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2Key Laboratory of Anesthesiology, Shanghai Jiao Tong University, Ministry of Education, Shanghai 200127, China;  \n3Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.  \nAbstract  \nIn recent years, growing evidence indicates that the nervous system plays an indispensable role in tumor development and metastasis. Elucidating crosstalk between the nervous system and tumor progression has thrived as a hot topic and a new direction for understanding cancer pathogenesis. Notably, many novel discoveries have suggested that neurotransmitter receptors (NRs) are not only widely expressed in cancer cells, but also play key roles in regulating cancer initiation and progression by diverse approaches. In this review, we summarized the latest advance in cancer neuroscience, especially emphasizing the important roles of different NRs in cancer development and prevention. The exemplary studies presented herein illustrate the emerging view that NRs are profoundly influential, manifested in tumor growth, apoptosis, angiogenesis, metastasis, resistance to drugs, and participate in the formation of neural–cancer interactions. In addition, NRs also regulate cellular metabolic processes and tumor microenvironment (TME) remodeling. More importantly, numerous basic and clinical studies have suggested that NRs may be potential targets for cancer treatments, and corresponding agonists or antagonists have been identified effectively in controlling tumor growth and metastasis. In conclusion, NRs are emerging as novel targets for anti-cancer drug exploration and clinical cancer treatments, while trying to uncover deeper mechanisms and connections between NRs and cancer is of high clinical significance and translational value.  \nKeywords: Cancer; Nervous system; Neurotransmitter; Neurotransmitter receptor; Tumor microenvironment; Cellular reprogramming  \nIntroduction  \nCancer is a leading cause of death and remains a major human health concern worldwide. [1] In 2000, Hanahan and Weinberg[2] first proposed the hallmarks of cancer, which were updated to encompass 14 characteristics in 2022.[3] The integrative concept embodied in the hallmarks of cancer helps distill this complexity of cancer into a logical science and fully understand the mechanisms of cancer progression. It is not surprising that the core conceptualization behind the hallmarks continues to resonate, though new evidence emerges. Notably, an emerging hallmark of cancer that is garnering increasing attention is the interplay between the nervous system and cancer. [4] A growing body of experimental evidence is reinforcing this connection and its various aspects, from the systemic effects of tumors on nervous system functionality to local remodeling of tissue innervation by tumors, as well as the modulatory effects of the nervous system on tumor phenotypes—topics that have been extensively reviewed. [4–7] Consequently, a burgeoning field known as “Cancer Neuroscience” has been established, inviting  \n\n| Access this article online |  |\n| --- | --- |\n| Quick Response Code: | Website:\u003Cbr>[www.cmj.org](www.cmj.org) |\n|  | DOI:\u003Cbr>10.1097/CM9.0000000000003656 |\n\nmultidisciplinary collaboration to further investigate the interactions between cancer and the nervous system. [5,6]  \nThe nervous system is typically characterized as a signaling network that regulates the development, plasticity, homeostasis, and regeneration of various organs and tissues. [8] By connecting organs to the central nervous system (CNS), nerves are essential to the body’s internal communication and proper physiological regulation. Given that the nervous system oversees numerous functions of the human body in both health","cbCaiaxKxwRcPK5J","https://ap.wps.com/l/cbCaiaxKxwRcPK5J","pdf",3345542,"English","# Abstract\n# Introduction","[{\"question\":\"What role does the nervous system play in cancer progression?\",\"answer\":\"The nervous system contributes centrally to cancer pathogenesis by influencing tumor development and metastasis, including both systemic effects and local remodeling of tissue innervation.\"},{\"question\":\"How do neurotransmitter receptors influence cancer?\",\"answer\":\"Neurotransmitter receptors are widely expressed in cancer cells and regulate cancer initiation and progression through diverse mechanisms affecting growth, apoptosis, angiogenesis, metastasis, and drug resistance.\"},{\"question\":\"Are neurotransmitter receptors potential targets for cancer treatment?\",\"answer\":\"Basic and clinical studies suggest neurotransmitter receptors may be potential therapeutic targets, with agonists or antagonists identified for controlling tumor growth and metastasis.\"}]","Cancer and neurotransmitter receptors - review article | PDF",1790194702,48]