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This study analyzed Canada-wide end-point quaking induced conversion (EP-QuIC) cerebrospinal fluid (CSF) test findings from 2016–2025, spanning pre-, during, and post-COVID-19 periods. EP-QuIC submissions increased during the pandemic, yet CJD incidence and major disease features remained stable, supporting continued vigilance in national surveillance.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/canadian-creutzfeldt-jakob-disease-incidence-remained-stable-during-the-coronavirus-disease-covid-19-pandemic/417553/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/canadian-creutzfeldt-jakob-disease-incidence-remained-stable-during-the-coronavirus-disease-covid-19-pandemic/417553.png","ImageObject",300,407,{"name":92,"@type":93},"Himbo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study’s purpose regarding CJD and COVID-19?","Question",{"text":113,"@type":114},"To determine whether the COVID-19 pandemic influenced Canadian CJD diagnostics and surveillance over 2016–2025.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were Canadian CJD diagnostics assessed in this report?",{"text":118,"@type":114},"The study compared Canada-wide EP-QuIC cerebrospinal fluid (CSF) assay findings across pre-, during-, and post-COVID-19 periods.",{"name":120,"@type":111,"acceptedAnswer":121},"Did CJD incidence change during the pandemic?",{"text":122,"@type":114},"No. Although EP-QuIC test submissions increased, CJD incidence was unaltered and not associated with SARS-CoV-2 incidence.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},417553,1790766032,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46,"preview_page_count":4},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","TYPE Original Research PUBLISHED 19 December 2025 DOI 10.3389/fneur.2025.1729083  \nOPEN ACCESS  \nEDITED BY  \nRodrigo Morales,  \nUniversity of Texas Health Science Center at Houston, United States  \nREVIEWED BY  \nMatteo Senesi,  \nThe University of Melbourne, Australia Adipa Chongsuksantikul,  \nKing Chulalongkorn Memorial Hospital, Thailand  \n*CORRESPONDENCE  \nStephanie A. Booth  \n [stephanie.booth@phac-aspc.gc.ca](stephanie.booth@phac-aspc.gc.ca)  \nRECEIVED 20 October 2025  \nREVISED 02 December 2025  \nACCEPTED 03 December 2025  \nPUBLISHED 19 December 2025  \nCITATION  \nSlota JA, Todoric D, Bergeron V, Avery K, Phillipson C, Kielich DMS, Myskiw J, Lamoureux L, Frost K, Simon SLR,  \nBailey-Elkin BA and Booth SA (2025) Canadian Creutzfeldt-Jakob disease incidence remained stable during the coronavirus disease (COVID-19) pandemic.  \nFront. Neurol. 16:1729083 .  \ndoi: 10.3389/fneur.2025.1729083  \nCOPYRIGHT  \n© 2025 Slota, Todoric, Bergeron, Avery, Phillipson, Kielich, Myskiw, Lamoureux, Frost, Simon, Bailey-Elkin and Booth. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nCanadian Creutzfeldt-Jakob disease incidence remained stable during the coronavirus disease (COVID-19) pandemic  \nJessy A. Slota 1, Dobrila Todoric 2, Vanessa Bergeron 2, Kristen Avery 1, Clark Phillipson 1, Dominic M. S. Kielich 1, Jennifer Myskiw 1, Lise Lamoureux 1, Kathy Frost 1, Sharon L. R. Simon 1, Ben A. Bailey-Elkin 1 and Stephanie A. Booth 1,3*  \n1Mycobacteriology, Vector-Borne and Prion Diseases Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada, 2Infectious Diseases and Vaccination Programs Branch, Public Health Agency of Canada, Ottawa, ON, Canada, 3Department of Medical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada  \nIntroduction: Healthcare disruptions imposed by the coronavirus disease (COVID-19) pandemic and possible biological links between SARS-CoV-2 and prion misfolding might influence the prevalence or characteristics of Creutzfeldt-Jakob Disease (CJD) . This report investigates the potential impact of the COVID-19 pandemic on Canadian CJD diagnostics and surveillance from 2016–2025.  \nMethods: Canada-wide CJD diagnostic findings from end-point quaking induced conversion (EP-QuIC) cerebrospinal fluid (CSF) assays were compared across three periods: pre- (2016-01-29 – 2020-02-28), during (2020-03-01 – 2022-09-30), and post-COVID-19 (2022-10-01 – 2025-09-29) . Presented are incidence rates and distributions of biomarker abundances, case demographics, CJD molecular subtypes, and disease durations.  \nResults: While EP-QuIC test submissions increased during the pandemic, CJD incidence was unaltered and not associated with SARS-CoV-2 incidence. Demographics, disease durations, and molecular subtypes of sporadic CJD (sCJD) were largely consistent across periods, although a higher proportion of females were tested during COVID and the prevalence of sCJD MV1 declined post-COVID.  \nConclusion: CJD prevalence and characteristics remained stable during COVID-19 despite increased EP-QuIC test submissions. These findings verify that CJD surveillance in Canada remained vigilant during the pandemic and highlight the value of EP-QuIC CSF testing for comprehensive CJD monitoring.  \nKEYWORDS  \ncoronavirus disease, Creutzfeldt-Jakob disease, diagnostics, prion disease, SARS-CoV- 2, surveillance  \nFrontiers in Neurology 01 [frontiersin.org](frontiersin.org)  \nIntroduction  \nCreutzfeldt-Jakob disease (CJD) is a rare, fatal, and transmissible neurodegenerative dis","cbCaipfBF5LNjglg","https://ap.wps.com/l/cbCaipfBF5LNjglg","pdf",5593776,"English","# Introduction\n## Methods\n## Results\n## Conclusion\n# Keywords","[{\"question\":\"What was the study’s purpose regarding CJD and COVID-19?\",\"answer\":\"To determine whether the COVID-19 pandemic influenced Canadian CJD diagnostics and surveillance over 2016–2025.\"},{\"question\":\"How were Canadian CJD diagnostics assessed in this report?\",\"answer\":\"The study compared Canada-wide EP-QuIC cerebrospinal fluid (CSF) assay findings across pre-, during-, and post-COVID-19 periods.\"},{\"question\":\"Did CJD incidence change during the pandemic?\",\"answer\":\"No. Although EP-QuIC test submissions increased, CJD incidence was unaltered and not associated with SARS-CoV-2 incidence.\"}]","Canadian Creutzfeldt-Jakob disease incidence remained stable during the coronavirus disease (COVID-19) pandemic | PDF",1790609585]