[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-454282-105":59,"doc-detail-454282-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","can-mini-dose-glucagon-prevent-fasting-induced-hypoglycemia-and-preserve-fasting","Can Mini-Dose Glucagon Prevent Fasting-Induced Hypoglycemia and Preserve Fasting?","","Individuals with diabetes, especially those using insulin, face heightened hypoglycemia risk during Ramadan fasting because of prolonged periods without food or drink. Mini-dose glucagon (MDG) is explored as an alternative to oral carbohydrates for mild or impending hypoglycemia without breaking the fast, though existing evidence remains limited and largely preliminary. This hypothesis-generating review integrates a small pilot RCT (n=17), an observational survey (n=136), and targeted literature search, suggesting short-term feasibility but leaving efficacy, safety, and optimal dosing inadequately defined.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/can-mini-dose-glucagon-prevent-fasting-induced-hypoglycemia-and-preserve-fasting/454282/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/can-mini-dose-glucagon-prevent-fasting-induced-hypoglycemia-and-preserve-fasting/454282.png","ImageObject",300,407,{"name":92,"@type":93},"Sophia Brooks","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is hypoglycemia a major concern for insulin-treated diabetes during Ramadan fasting?","Question",{"text":112,"@type":113},"Hypoglycemia is the most frequent insulin-treatment complication and fasting increases dependence on impaired counter-regulation. This raises susceptibility to low blood glucose during prolonged periods without food or drink.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is mini-dose glucagon (MDG) intended to do during fasting?",{"text":117,"@type":113},"MDG is considered to treat or help prevent mild or impending hypoglycemia without requiring oral carbohydrate intake, thereby avoiding breaking the fast.",{"name":119,"@type":110,"acceptedAnswer":120},"What limits the current confidence in MDG’s clinical effectiveness and safety?",{"text":121,"@type":113},"Available studies are preliminary with small sample sizes, heterogeneity in study designs, and investigator involvement, leaving key questions about efficacy, safety, and optimal dosing unresolved.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},454282,1791370164,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962084925636,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Review began 10/12/2025  \nReview ended 12/05/2025  \nPublished 12/07/2025  \n© Copyright 2025  \nAlgeffari. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98620  \nOpen Access Review Article  \nCan Mini-Dose Glucagon Prevent Fasting-Induced Hypoglycemia and Preserve Fasting?  \nMetab Algeffari 1  \n1. Department of Family and Community Medicine, College of Medicine, Qassim University, Buraydah, SAU Corresponding author: Metab Algeffari, [m.geffari@qu.edu.sa](m.geffari@qu.edu.sa)  \nAbstract  \nIndividuals with diabetes, particularly those using insulin, face substantial challenges when fasting during the Islamic month of Ramadan due to prolonged periods without food or drink and an increased risk of hypoglycemia. Mini-dose glucagon (MDG) has been considered as an alternative to oral carbohydrate intake for mild or impending hypoglycemia without breaking the fast; however, current evidence is limited and remains preliminary, derived largely from small pilot studies and limited real-world data.  \nThis hypothesis-generating review synthesizes findings from a pilot RCT (n=17), an observational survey (n=136), and a focused literature search, providing the reader with the best evidence so far on this topic. Across the available evidence, MDG appears feasible for short-term correction of mild hypoglycemia, yet its efficacy, safety, and optimal dosing during fasting remain insufficiently established. Limitations of the present studies, such as small sample sizes, investigators ' involvement, and heterogeneity in study designs, suggest cautious interpretation.  \nConsidering the relatively early nature of the evidence and the importance of patient safety at fasting times, the use of MDG cannot be regarded as a proven or routine strategy. Larger, independently conducted studies are required to clarify its clinical role, validate dosing protocols, and ensure alignment with safety-first recommendations for fasting individuals with diabetes.  \nCategories: Endocrinology/Diabetes/Metabolism  \nKeywords: diabetes, fasting, glucagon, hypoglycemia, mini-dose, ramadan  \nIntroduction And Background  \nHypoglycemia is the most frequent complication of insulin treatment in diabetes and is currently the major obstacle to achieving near normal glucose concentrations [1,2] . It has been reported that 5-10% of children and adults with type 1 diabetes (T 1D) experience a severe hypoglycemic episode every year, which is usually associated with noticeable neurocognitive dysfunction, coma, or seizures [2,3] . In addition, repeated hypoglycemic episodes are a risk factor for the development of hypoglycemic unawareness, a condition that greatly increases the chances of severe hypoglycemia [1,2] . This life-threatening state can often lead to costly emergency medical treatment or admission to acute care facilities [4] . In addition to its physical health consequences, severe hypoglycemia has a severe negative effect on the psychological and emotional well-being of patients and their families and thus affects their quality of life adversely [5,6] . Despite advancements in insulin formulations and delivery devices, the risk of hypoglycemia remains a significant concern, contributing to both the acute and long-term complications of diabetes [2-7].  \nIn normal physiology, glucagon plays an important role in regulating blood glucose levels to prevent hypoglycemia by acting as a counterregulatory hormone, raising blood glucose levels to prevent low blood sugar. During fasting, this delicate insulin-glucagon balance becomes increasingly dependent on hepatic responsiveness and insulin sensitivity. As a result of T 1D, however, this defense mechanism is impaired atan early stage [8-10], and the combination of relative insulin deficiency and variable insulin","cbCaidUexXMK1kSq","https://ap.wps.com/l/cbCaidUexXMK1kSq","pdf",743354,"English","# Introduction and Background\n## Mini-dose glucagon as a fasting alternative\n# Review Method and Evidence Summary\n## Findings on feasibility and limitations\n# Clinical Implications and Research Needs","[{\"question\":\"Why is hypoglycemia a major concern for insulin-treated diabetes during Ramadan fasting?\",\"answer\":\"Hypoglycemia is the most frequent insulin-treatment complication and fasting increases dependence on impaired counter-regulation. This raises susceptibility to low blood glucose during prolonged periods without food or drink.\"},{\"question\":\"What is mini-dose glucagon (MDG) intended to do during fasting?\",\"answer\":\"MDG is considered to treat or help prevent mild or impending hypoglycemia without requiring oral carbohydrate intake, thereby avoiding breaking the fast.\"},{\"question\":\"What limits the current confidence in MDG’s clinical effectiveness and safety?\",\"answer\":\"Available studies are preliminary with small sample sizes, heterogeneity in study designs, and investigator involvement, leaving key questions about efficacy, safety, and optimal dosing unresolved.\"}]","Can Mini-Dose Glucagon Prevent Fasting-Induced Hypoglycemia and Preserve Fasting? | PDF",1790740436,25]