[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-379052-105":59,"doc-detail-379052-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","can-echinococcus-granulosus-infestation-prevent-pancreatic-cancer-an-in-vivo-experimental-study","Can Echinococcus Granulosus Infestation Prevent Pancreatic Cancer - An In vivo Experimental Study","","Hydatid cyst is a zoonotic infestation caused by Echinococcus granulosus, with evidence that some parasites can inhibit cancer development or exert cancer-promoting effects. This in vivo study evaluates whether E. granulosus suppresses exocrine pancreatic cancer precursor changes using an azaserine-rat model. Forty-five male Wistar rats were allocated to control, azaserine-only, protoscolex-only, or combined azaserine plus protoscolex groups. Atypical acinar cell foci (AACF) burden was quantified and analyzed. The combined group showed significantly lower AACF burden, suggesting inhibition of precursor foci and new insight into the controversy of Echinococcosis and pancreatic cancer.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/can-echinococcus-granulosus-infestation-prevent-pancreatic-cancer-an-in-vivo-experimental-study/379052/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/can-echinococcus-granulosus-infestation-prevent-pancreatic-cancer-an-in-vivo-experimental-study/379052.png","ImageObject",300,407,{"name":92,"@type":93},"Sophia Brooks","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the aim of the study?","Question",{"text":112,"@type":113},"To determine whether Echinococcus granulosus can inhibit exocrine pancreatic cancer precursor changes in rats using the azaserine-rat model.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the rats grouped and treated?",{"text":117,"@type":113},"Forty-five male Wistar rats were divided into a control group, an azaserine-only group, a protoscolex-only group, and a group receiving both azaserine and protoscolex by injection.",{"name":119,"@type":110,"acceptedAnswer":120},"What was the main outcome measured?",{"text":121,"@type":113},"The study quantitatively measured the load of atypical acinar cell foci (AACF) in the exocrine pancreas using image analysis and a mathematical model.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},379052,1790342599,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962084925636,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","RESEARCH ARTICLE  \nEditorial Process: Submission:12/07/2022 Acceptance:04/18/2023  \nCanEchinococcus Granulosus Infestation Prevent Pancreatic Cancer? An In vivo Experimental Study  \nSerhat Doğan1, Murat Çakir2, Adil Kartal2, Haydar Öztaş3 *, Pembe Oltulu4 Abstract  \nHydatid cyst is a zoonotic infestation caused by Echinococcus granulosus, and it is known that some parasites found in humans cause cancer in humans or some may have a protective effect against cancer. Cancer is one of the most serious health problems of today and it has been shown in some studies that parasites such as Echinococcus granulosus can have an inhibitory effect. The aim of this study was determined as whether Echinococcus granulosushas an inhibitory effect on exocrine pancreatic cancer with the help of the azaserine-rat model used in different cancer studies. Material and Methods: During experimental process a total of 45 male Wistar rats used, 14-day-old male Wistar rats were divided into groups according to the experimental protocol, administered azaserine injection protocol or kept as a control group without azaserine injection. Animals are grouped as Group 1, Control Group (group not treated with Azaserine and not injected with protoscolex.) (E-A-) (n=7); Group 2, Group injected with (IP) Azaserine only (30mg/ kg) (E-A+) (n=8);Group 3, Group injected (IP) with protoscolex suspension of 1 cc only (E+A-) (n=15);Group 4, Group injected both Azaserine (IP) and protoscolex suspension (IP) (E+A+) (n=15). Atypical Acinar Cell Foci (AACF) load in the exocrine pancreas of each rat was measured quantitatively with the help of a video image analyzer and the AACF load was calculated with the help of a mathematical model. Results: Findings showed that the Atypical Acinar Cell Foci (AACF) burden was statistically significantly lower in the Azaserine+ protoscolex (Azaserine-injectedprotoscolex-implanted) rat group compared to the other groups, suggesting that Echinococcosis in the azaserine-rat model could inhibit the development of precursor foci of neoplastic changes in the exocrine pancreas. Conclusion: The most significant aspect of our study is that it contributes new insights into the controversy that Echinococcosis suppresses pancreatic cancer.  \nKeywords: Echinococcus granulosus-azaserine-rats-pancreatic cancer  \nAsian Pac J Cancer Prev, 24 (4), 1307-1312  \nIntroduction  \nHydatid cyst is a zoonotic infestation caused by Echinococcus granulosus (EG) . It is widely seen in the Mediterranean countries, the Middle East, South America, New Zealand, Australia and SouthEastern Asia (Karamanet al. , 2011; Lynen et al. , 2011) . In addition to this, cancer is one of the most significant healthcare problems today. There are also articles reporting that parasites can lead to or inhibit cancer in humans (Akgül et al., 2003; Alvarez-Errico et al., 2001) . However, it is not known exactly what kind of histopathological change parasites bring about in the pancreas in vivo animal experiments (Rhim and Stanger, 2010; Noya et al., 2013) .  \nIt is assumed that pancreatic ductal adenocarcinoma (PDAC) completes its developmental process from a precursor lesion into cancer through multiple stages.  \nPancreatic intraepithelial neoplasia (PanIN) is a precursor lesion frequently detected in the pancreas of pancreatic cancer patients (Longnecker and Curphey, 1975; Rhim and Stanger, 2010; Vincent et al., 2011; Ji et al., 2009; Gourgou-Bourgade et al., 2011) . It has been found that preneoplastic structures in the pancreas were seen in 80% of these cases (Hruban et al., 2008) . KRAS oncogene is a well-known mutant gene that leads to pancreatic cancer. KRAS oncogene leads tothe inactivation of tumor suppressor genes CDKN2A, TP53, DPC4 and BRCA2 .  \nLoss of chromosomes, gene amplification and telomere contraction are usually observed anomalies in pancreatic cancer cases in which activation of this gene is involved (Vincent et al., 2011) . It has been reported that antigenic properties ","cbCaii4BSJdxF3V0","https://ap.wps.com/l/cbCaii4BSJdxF3V0","pdf",780627,"English","# Introduction\n## Hydatid cyst, E. granulosus, and cancer context\n## Pancreatic precursor lesions and molecular background\n# Materials and Methods\n## Animal model, groups, and treatment\n## AACF measurement and analysis","[{\"question\":\"What was the aim of the study?\",\"answer\":\"To determine whether Echinococcus granulosus can inhibit exocrine pancreatic cancer precursor changes in rats using the azaserine-rat model.\"},{\"question\":\"How were the rats grouped and treated?\",\"answer\":\"Forty-five male Wistar rats were divided into a control group, an azaserine-only group, a protoscolex-only group, and a group receiving both azaserine and protoscolex by injection.\"},{\"question\":\"What was the main outcome measured?\",\"answer\":\"The study quantitatively measured the load of atypical acinar cell foci (AACF) in the exocrine pancreas using image analysis and a mathematical model.\"}]","Can Echinococcus Granulosus Infestation Prevent Pancreatic Cancer - An In vivo Experimental Study | PDF",1790233906,15]