[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-426137-105":59,"doc-detail-426137-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","caloric-restriction-and-changes-in-geroscience-blood-based-biomarkers-in-older-adults-abstract","CALORIC RESTRICTION AND CHANGES IN GEROSCIENCE BLOOD-BASED BIOMARKERS IN OLDER ADULTS - Abstract","","Clinical trials targeting the biology of aging require intermediate endpoints to assess intervention effects. This study evaluated associations between caloric restriction (CR), achieved weight loss, and a consensus panel of blood-based geroscience biomarkers in 768 older adults drawn from six completed CR trials. Plasma CRP, IL-6, TNFr1, GDF15, cystatin C, and insulin were measured at baseline and 6 months. CR improved CRP and insulin, while weight loss decreased CRP, IL-6, and insulin, with no CR-group differences for several other markers.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/caloric-restriction-and-changes-in-geroscience-blood-based-biomarkers-in-older-adults-abstract/426137/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/caloric-restriction-and-changes-in-geroscience-blood-based-biomarkers-in-older-adults-abstract/426137.png","ImageObject",300,407,{"name":92,"@type":93},"Cipher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-10","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main goal regarding caloric restriction?","Question",{"text":112,"@type":113},"To evaluate how caloric restriction and achieved weight loss relate to changes in a blood-based panel of geroscience biomarkers in older adults.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which biomarkers were measured, and when were they assessed?",{"text":117,"@type":113},"Plasma CRP, IL-6, TNFr1, GDF15, cystatin C, and insulin were measured at baseline and 6 months after randomization to CR or no CR.",{"name":119,"@type":110,"acceptedAnswer":120},"Which biomarkers showed significant improvement with caloric restriction?",{"text":121,"@type":113},"CR was associated with significant improvements in CRP and insulin compared with no CR, while IL-6, TNFr1, GDF15, and cystatin C did not differ significantly.",{"name":123,"@type":110,"acceptedAnswer":124},"How did achieved weight loss affect the biomarkers?",{"text":125,"@type":113},"Achieved weight loss was associated with significant decreases in CRP, IL-6, and insulin over 6 months.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},426137,1790793304,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":24},687208528416,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","302 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.1020  \nCALORIC RESTRICTION AND CHANGES IN  \nGEROSCIENCE BLOOD-BASED BIOMARKERS IN  \nOLDER ADULTS  \nFang-Chi Hsu, Rebecca Neiberg, Michael Miller,  \nPhilip Kramer, John Stone, Denise Houston, Barbara Nicklas, and Stephen Kritchevsky, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States  \nIntermediate endpoints are needed to evaluate the effect of interventions targeting the biology of aging in clinical trials. We  \nInnovation in Aging, 2025, Vol. 9, No. S2 303  \nexamined associations between randomization to caloric restriction (CR), as well as achieved weight loss, and a consensus derived panel of blood-based geroscience biomarkers in 768 older adults (mean age, 67.4±5.2 years; 68% female and 81% Caucasian) . Participants were randomly selected from six completed CR trials to provide a representative subset from each randomized group (CR vs. no CR) within each trial. Plasma CRP, IL-6, TNFr1, GDF15, cystatin C and insulin were measured at baseline and 6-months post-randomization to CR or no CR by the immunoassay platform Ella. Mean±SD weight loss over  \n6 months was 8.0±5.8 kg in the CR group and 1.4±3.7 kg in the no CR group. CR was associated with significant improvements in CRP and insulin compared to no CR (mean difference [95% CI]: -1.1 [-0.2, -1.9] mg/L and-15.3 [-8.1, -22.6] pmol/mL, respectively); however, there were no significant differences in IL-6, TNFr1, GDF15, or cystatin C by CR group. Achieved weight loss was associated with significant decreases in CRP, IL-6, and insulin (standardized betas (95% CI) per SD weight change: log transformed CRP: -0.26 (-0.13, -0.36), p \u003C 0.0001; log transformed IL-6: -0.13 (-0.03, -0.23), p = 0.01; and insulin:  \n-0.25 (-0.15, -0.36), p \u003C 0.0001). We will also report the relationship between CR and a composite biomarker index. These results suggest that blood-based geroscience biomarkers are responsive to short-term CR, particularly those involved in inflammation and nutrient signaling.","cbCaicdlKErfn6h8","https://ap.wps.com/l/cbCaicdlKErfn6h8","pdf",604304,"English","# Overview\n## Study design and biomarker panel\n## CR effects vs. weight loss associations","[{\"question\":\"What was the study’s main goal regarding caloric restriction?\",\"answer\":\"To evaluate how caloric restriction and achieved weight loss relate to changes in a blood-based panel of geroscience biomarkers in older adults.\"},{\"question\":\"Which biomarkers were measured, and when were they assessed?\",\"answer\":\"Plasma CRP, IL-6, TNFr1, GDF15, cystatin C, and insulin were measured at baseline and 6 months after randomization to CR or no CR.\"},{\"question\":\"Which biomarkers showed significant improvement with caloric restriction?\",\"answer\":\"CR was associated with significant improvements in CRP and insulin compared with no CR, while IL-6, TNFr1, GDF15, and cystatin C did not differ significantly.\"},{\"question\":\"How did achieved weight loss affect the biomarkers?\",\"answer\":\"Achieved weight loss was associated with significant decreases in CRP, IL-6, and insulin over 6 months.\"}]","CALORIC RESTRICTION AND CHANGES IN GEROSCIENCE BLOOD-BASED BIOMARKERS IN OLDER ADULTS - Abstract | PDF",1790639490]