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The reported case describes a 40-year-old woman with SLE who developed painful skin lesions over both popliteal regions, accompanied by generalized aches, persistent nocturnal fever, polyarticular joint pain, pruritus, hair loss, dry mouth, and right hip swelling. Imaging showed multiple soft tissue calcifications and histopathology confirmed calcinosis cutis. Surgical excision plus immunosuppressive therapy was followed by an infected wound requiring antibiotics and repeat excision. The condition is rare and warrants early suspicion for timely diagnosis and treatment.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/calcinosis-cutis-in-a-patient-with-systemic-lupus-erythematosus-a-case-report/423063/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/calcinosis-cutis-in-a-patient-with-systemic-lupus-erythematosus-a-case-report/423063.png","ImageObject",300,407,{"name":92,"@type":93},"dabgoudw","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the primary diagnosis in the case report?","Question",{"text":113,"@type":114},"The patient had systemic lupus erythematosus (SLE) complicated by calcinosis cutis, confirmed by histopathological examination.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What clinical and laboratory findings supported the diagnosis?",{"text":118,"@type":114},"The case included painful bilateral popliteal skin lesions, systemic symptoms, positive antinuclear antibody (ANA) and anti-dsDNA antibodies, normal serum calcium/phosphorus, elevated ESR, and radiographic soft tissue calcifications.",{"name":120,"@type":111,"acceptedAnswer":121},"How was calcinosis cutis managed after initial treatment?",{"text":122,"@type":114},"Surgical excision was performed and immunosuppressive agents were given; one month later, the patient developed a persistent infected wound treated with antibiotics and then underwent repeat surgical excision.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},423063,1790695689,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46,"preview_page_count":4},3985747860484,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Review began 10/30/2025  \nReview ended 11/18/2025  \nPublished 12/04/2025  \n© Copyright 2025  \nOsman Ahmed Osman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98457  \nOpen Access Case Report  \nCalcinosis Cutis in a Patient With Systemic Lupus Erythematosus: A Case Report  \nMohammed Osman Ahmed Osman 1 , Ziryab Imad 2, Yassin Abdalla 3 , Salih Boushra Hamza 4 , Mohammedelmuntaga Gafar 5, Obada Mohamed Ahmed Ali 6  \n1. Internal Medicine, The National Ribat University, Khartoum, SDN 2. Internal Medicine and Rheumatology, University of Bahri, Khartoum, SDN 3. Internal Medicine, Omdurman Islamic University Faculty of Medicine and Health Sciences, Khartoum, SDN 4. Internal Medicine, Omdurman Islamic University, Omdurman, SDN 5. Internal Medicine and Rheumatology, Alzaiem Alazhari University Faculty of Medicine, Khartoum, SDN 6. Internal Medicine, University of Bahri College of Medicine, Khartoum, SDN  \nCorresponding author: Mohammed Osman Ahmed Osman, [mhmdosman50634@gmail.com](mhmdosman50634@gmail.com)  \nAbstract  \nSystemic lupus erythematosus (SLE) is a systemic, remitting, and relapsing autoimmune disease. It is associated with deficiency of early complement proteins, impaired clearance of immune complexes, and numerous clinical manifestations and morbidities.  \nWe report the case of a 40-year-old woman with a known diagnosis of systemic lupus erythematosus (SLE) who presented to the outpatient department with painful skin lesions over the left and right popliteal regions. She also reported generalized body aches, persistent fever that worsened at night, pain in multiple small and large joints, pruritus, hair loss, dry mouth, and right hip swelling for five years. Blood investigations revealed a positive antinuclear antibody (ANA) titer of 1: 160 and positive anti-dsDNA antibodies, with normal serum calcium and phosphorus levels and an elevated erythrocyte sedimentation rate (ESR) . Radiographs of both knees and the pelvis demonstrated multiple soft tissue calcifications of varying sizes. Histopathological examination revealed dense, massive calcified material in the subcutaneous tissue, confirming a diagnosis of calcinosis cutis. Surgical excision of the lesion was performed, and immunosuppressive agents were administered. However, one month later, the patient re-presented with a persistent infected wound that required antibiotic therapy. She subsequently received further medical treatment and underwent repeat surgical excision.  \nCalcinosis cutis is an exceedingly rare but potentially unfavorable complication of systemic lupus erythematosus, with only a limited number of cases reported in the literature, and it is most often associated with underlying cutaneous pathology. Clinicians must maintain a high index of suspicion to assure early diagnosis and treatment.  \nCategories: Internal Medicine, Rheumatology, Allergy/Immunology  \nKeywords: calcification, calcinosis cutis, connective tissue disorder, dystrophic, systemic lupus erythematosus  \nIntroduction  \nCalcinosis cutis is a rare, chronic, and potentially disabling condition characterized by the deposition of insoluble calcium salts in the skin, subcutaneous tissue, joints, ligaments, and muscles. It may result insignificant pain and functional impairment and is most commonly associated with autoimmune connective tissue diseases [1] . Among these, systemic sclerosis and dermatomyositis show the strongest association with its development [2] . Only a limited number of cases have been reported in patients with systemic lupus erythematosus (SLE) . Soft tissue calcifications are classified into five major types: dystrophic, metastatic, idiopathic, tumoral, and calciphylaxis [3-10]. The dystrophic type occurs in areas of tissue destruction with  \nnorma","cbCaifKil0qlWRRh","https://ap.wps.com/l/cbCaifKil0qlWRRh","pdf",4153478,"English","# Abstract\n# Introduction\n# Case Presentation\n## How to cite this article","[{\"question\":\"What was the primary diagnosis in the case report?\",\"answer\":\"The patient had systemic lupus erythematosus (SLE) complicated by calcinosis cutis, confirmed by histopathological examination.\"},{\"question\":\"What clinical and laboratory findings supported the diagnosis?\",\"answer\":\"The case included painful bilateral popliteal skin lesions, systemic symptoms, positive antinuclear antibody (ANA) and anti-dsDNA antibodies, normal serum calcium/phosphorus, elevated ESR, and radiographic soft tissue calcifications.\"},{\"question\":\"How was calcinosis cutis managed after initial treatment?\",\"answer\":\"Surgical excision was performed and immunosuppressive agents were given; one month later, the patient developed a persistent infected wound treated with antibiotics and then underwent repeat surgical excision.\"}]","Calcinosis Cutis in a Patient With Systemic Lupus Erythematosus - A Case Report | PDF",1790629993]