[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-366600-105":59,"doc-detail-366600-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","c15orf48-serves-as-a-potential-biomarker-and-therapeutic-target-in-pan-cancer-with-implications-for-lung-cancer","C15ORF48 serves as a potential biomarker and therapeutic target in pan-cancer with implications for lung cancer","","C15ORF48 expression is frequently elevated in tumor tissues, yet its pan-cancer relevance and biological significance remain insufficiently defined. This study evaluates C15ORF48 expression patterns, immune infiltration associations, and prognostic value across multiple cancers using TIMER2.0, GEPIA, and the Human Protein Atlas, supported by cBioPortal, PhosphoNET, and AlphaFold for genetic alterations and phosphorylation hotspot analysis. Results indicate cytoplasmic predominance in lung tissue, correlation with CD8+ T cell infiltration, and poorer survival in lung adenocarcinoma, suggesting biomarker and therapeutic targeting potential.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/c15orf48-serves-as-a-potential-biomarker-and-therapeutic-target-in-pan-cancer-with-implications-for-lung-cancer/366600/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/c15orf48-serves-as-a-potential-biomarker-and-therapeutic-target-in-pan-cancer-with-implications-for-lung-cancer/366600.png","ImageObject",300,407,{"name":92,"@type":93},"Ben ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How was C15ORF48 analyzed across pan-cancer in this study?","Question",{"text":112,"@type":113},"The study assessed C15ORF48 expression using TIMER2.0, GEPIA, and the Human Protein Atlas, and evaluated genetic alterations and phosphorylation hotspots with cBioPortal, PhosphoNET, and AlphaFold.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What relationship does C15ORF48 show with immune infiltration in lung tissue?",{"text":117,"@type":113},"C15ORF48 expression is positively associated with the degree of CD8+ T cell infiltration, supporting a link between the gene and tumor immune microenvironment.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is C15ORF48 considered promising for prognosis or targeted therapy?",{"text":121,"@type":113},"Higher C15ORF48 expression correlates with poorer survival in lung adenocarcinoma, while genetic alteration and phosphorylation hotspot findings across cancers suggest functional involvement that could inform biomarker discovery and targeted therapeutic strategies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},366600,1790219453,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},2336478951081,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nC15ORF48 serves as a potential biomarker and therapeutic target in pan-cancer with implications for lung cancer  \nJianhang Ren1, Houcheng Zhu2, Miao Liu1, Ruibin Zhang1, Weixu Mao1 & Shunqiong Xiao1􀀍  \nLung cancer ranks among the top causes of cancer-related deaths globally. Prompt diagnosis and timely intervention play a vital role in enhancing patient prognosis and increasing survival chances. Although C15ORF48 expression is generally elevated in tumor tissues, it is reduced in specific cancers like colorectal cancer, and its role across pan-cancer remains unclear. This research investigates the expression, immune infiltration, and predictive significance ofC15ORF48 in pan-cancer using multiple databases, including TIMER2.0, GEPIA, and the Human Protein Atlas. Additionally, we use cBioPortal, PhosphoNET, and AlphaFold to analyze the distribution of genetic alterations, phosphorylation sites, and pathogenic hotspots inC15ORF48. C15ORF48 expression is generally elevated in tumor versus normal tissues, and its distribution in lung tissues is predominantly cytoplasmic. C15ORF48 expression is positively correlated with the level of expression shows a positive association with the degree of CD8 +T cell infiltration.,etc. Furthermore, higher C15ORF48 expression is associated with poorer survival in lung adenocarcinoma, etc. Genetic alterations in C15orf48, including S29F, T38I, and K61N, and predicted phosphorylation sites such as S28, S29, T38, and T53, are identified across various cancers. Additionally, pathogenic hotspots, including G25D, S28K, and T38W, are highlighted. The results indicate that C15ORF48 could play a significant role in pan-cancer, particularly in lung cancer, and may serve as a potential biomarker for prognosis and targeted therapies.  \nKeywords C15ORF48, AlphaFold, Immune infiltration, Lung cancer, Overall survival, Pan-cancer  \nCancer is the second leading cause of death in the United States and the primary cause among individuals under 85 years. Incidence rates rose gradually from 1975, peaking at approximately 500 per 100,000 around 1990, before declining and stabilizing at about 470 per 100,000 by 20201. Lung cancer ranks as the second most prevalent malignancy globally and remains a primary contributor to cancer-associated mortality2. And lung cancer as the leading cause of cancer-related deaths, with an estimated 2.5 million new cases and 1.8 million deaths in 20223. In the United States alone, an estimated 234,580 new cases of lung and bronchial cancer are projected for 2024, with approximately 125,070 deaths attributed to these diseases, accounting for about 21% of all cancer-related mortality1. Cancer treatment has advanced from early surgical and radiotherapeutic approaches to contemporary multimodal strategies incorporating chemotherapy, targeted agents, and immunotherapies4. Looking ahead, future therapies will prioritize early detection, advanced immunotherapies, nanomedicines, stem cell interventions, and emerging techniques5. For lung cancer in particular, timely diagnosis and timely therapy of lung cancer are crucial for improving patient survival rates6. However, there is still a lack of reliable biomarkers for early diagnosis. Therefore, identifying new biomarkers and targeted therapeutic pathways remains an urgent research challenge.  \nC15ORF48 was initially discovered in studies of esophageal squamous cell carcinoma (ESCC)7 exhibits high expression levels in esophageal tissues and also significantly expressed in stomach and intestines8. The role of C15ORF48 remains unclear, but it has been identified as being associated with inflammatory responses9. Its expression has been shown to be reduced in colorectal cancer10. Methylation of C15orf48, which is associated with gene downregulation, has been confirmed in cervical squamous cell carcinoma cells11. Future studies could employ CRISPR screening to identify C15OR","cbCaibkkwhH71tRd","https://ap.wps.com/l/cbCaibkkwhH71tRd","pdf",1112899,"English","# Introduction\n# C15ORF48 characterization in pan-cancer\n## Expression patterns and tissue localization\n## Immune infiltration correlation\n## Prognostic significance and lung adenocarcinoma outcomes\n# Genetic alterations and phosphorylation hotspot analysis\n## Identified alterations\n## Predicted phosphorylation sites and hotspots\n# Implications for biomarkers and targeted therapy","[{\"question\":\"How was C15ORF48 analyzed across pan-cancer in this study?\",\"answer\":\"The study assessed C15ORF48 expression using TIMER2.0, GEPIA, and the Human Protein Atlas, and evaluated genetic alterations and phosphorylation hotspots with cBioPortal, PhosphoNET, and AlphaFold.\"},{\"question\":\"What relationship does C15ORF48 show with immune infiltration in lung tissue?\",\"answer\":\"C15ORF48 expression is positively associated with the degree of CD8+ T cell infiltration, supporting a link between the gene and tumor immune microenvironment.\"},{\"question\":\"Why is C15ORF48 considered promising for prognosis or targeted therapy?\",\"answer\":\"Higher C15ORF48 expression correlates with poorer survival in lung adenocarcinoma, while genetic alteration and phosphorylation hotspot findings across cancers suggest functional involvement that could inform biomarker discovery and targeted therapeutic strategies.\"}]","C15ORF48 serves as a potential biomarker and therapeutic target in pan-cancer with implications for lung cancer | PDF",1790166370]