[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331635-105":59,"doc-detail-331635-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","butyrate-as-a-potential-modulator-in-gynecological-disease-progression-review","Butyrate as a Potential Modulator in Gynecological Disease Progression - Review","","This review investigates butyrate, a short-chain fatty acid produced by gut microbiota, as a therapeutic modulator for preventing and treating gynecological diseases including polycystic ovary syndrome (PCOS), endometriosis, and cervical or ovarian cancers. Conventional therapies often yield limited, temporary relief with notable side effects and recurrence risk. Butyrate’s histone deacetylase (HDAC) inhibition is highlighted for modulating gene expression, immune responses, and inflammation, improving hormone balance and insulin sensitivity in PCOS.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/butyrate-as-a-potential-modulator-in-gynecological-disease-progression-review/331635/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/butyrate-as-a-potential-modulator-in-gynecological-disease-progression-review/331635.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role does butyrate play in gynecological disease progression?","Question",{"text":112,"@type":113},"Butyrate is proposed as a modulator that can influence gene expression, immune responses, and inflammation, helping prevent and treat multiple gynecological conditions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which gynecological diseases are covered in this review?",{"text":117,"@type":113},"The review focuses on PCOS, endometriosis, and gynecologic cancers including cervical and ovarian cancer.",{"name":119,"@type":110,"acceptedAnswer":120},"How might diet affect butyrate levels and therapeutic outcomes?",{"text":121,"@type":113},"High-fiber and Mediterranean-style dietary interventions are suggested to increase butyrate production via microbiota modulation, potentially supporting better therapeutic results.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331635,1790497713,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":26,"preview_page_count":4},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Review  \nButyrate as a Potential Modulator in Gynecological Disease Progression  \nNayeon Kim and Changwon Yang *  \nCitation: Kim, N.; Yang, C. Butyrateas a Potential Modulator in Gynecological Disease Progression. Nutrients 2024, 16, 4196. [https://](https://)[ ](https://)[doi.org/10.3390/nu16234196](doi.org/10.3390/nu16234196)  \nAcademic Editor: Alba RodriguezNogales  \nReceived: 15 November 2024  \nRevised: 30 November 2024  \nAccepted: 3 December 2024  \nPublished: 4 December 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nDepartment of Science Education, Ewha Womans University, Seoul 03760, Republic of Korea; [nayeon7112@ewha.ac.kr](nayeon7112@ewha.ac.kr)  \n* Correspondence: [cyang@ewha.ac.kr](cyang@ewha.ac.kr)  \nAbstract: This review investigates the therapeutic potential of butyrate, a short-chain fatty acid (SCFA) produced by gut microbiota, in the prevention and treatment of various gynecological diseases, including polycystic ovary syndrome (PCOS), endometriosis, and gynecologic cancers like cervical and ovarian cancer. These conditions often pose treatment challenges, with conventional therapies offering limited and temporary relief, significant side effects, and a risk of recurrence. Emerging evidence highlights butyrate’s unique biological activities, particularly its role as a histone deacetylase (HDAC) inhibitor, which allows it to modulate gene expression, immune responses, and inflammation. In PCOS, butyrate aids in restoring hormonal balance, enhancing insulin sensitivity, and reducing chronic inflammation. For endometriosis, butyrate appears to suppress immune dysregulation and minimize lesion proliferation. Additionally, in cervical and ovarian cancers, butyrate demonstrates anticancer effects through mechanisms such as cell cycle arrest, apoptosis induction, and suppression of tumor progression. Dietary interventions, particularly high-fiber and Mediterranean diets, that increase butyrate production are proposed as complementary approaches, supporting natural microbiota modulation to enhance therapeutic outcomes. However, butyrate’s short half-life limits its clinical application, spurring interest in butyrate analogs and probiotics to maintain stable levels and extend its benefits. This review consolidates current findings on butyrate’s multifaceted impact across gynecological health, highlighting the potential for microbiota-centered therapies in advancing treatment strategies and improving women’s reproductive health.  \nKeywords: gynecological diseases; short-chain fatty acids; butyrate; microbiota; high-fiber diet; cervical cancer; ovarian cancer; endometrial cancer; polycystic ovary syndrome; endometriosis  \n1. Introduction  \nGynecological diseases, referring to disorders of the female reproductive system, pose significant public health and societal challenges. This broad category includes a variety of benign and malignant tumors as well as endocrine disorders, including polycystic ovary syndrome (PCOS) and endometriosis. These conditions profoundly affect women’s quality of life, impacting their physical health, emotional well-being, and reproductive capabilities. Unfortunately, most current therapies offer only temporary relief, often come with undesirable side effects, may interfere with the ability to conceive, and carry a risk of symptom recurrence after discontinuation. In the management of various health conditions, especially gynecological disorders, proactive measures can significantly reduce the incidence and severity of diseases.  \nNutrition plays a critical role in managing gynecological diseases through its impact on hormonal balance, inflammation, and metabolic health [1] . Diets","cbCaih4pyIrV9aoa","https://ap.wps.com/l/cbCaih4pyIrV9aoa","pdf",2072072,24,"English","# Abstract\n# Keywords\n# 1. Introduction\n## Nutrition and diet in gynecological disease management\n## Microbiota characterization and health/disease links","[{\"question\":\"What role does butyrate play in gynecological disease progression?\",\"answer\":\"Butyrate is proposed as a modulator that can influence gene expression, immune responses, and inflammation, helping prevent and treat multiple gynecological conditions.\"},{\"question\":\"Which gynecological diseases are covered in this review?\",\"answer\":\"The review focuses on PCOS, endometriosis, and gynecologic cancers including cervical and ovarian cancer.\"},{\"question\":\"How might diet affect butyrate levels and therapeutic outcomes?\",\"answer\":\"High-fiber and Mediterranean-style dietary interventions are suggested to increase butyrate production via microbiota modulation, potentially supporting better therapeutic results.\"}]","Butyrate as a Potential Modulator in Gynecological Disease Progression - Review | PDF",1789994380]