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Strong associations link PDO-based readouts with clinical outcomes, supporting their use to forecast chemotherapy and/or radiotherapy efficacy. To improve interpretation and enable consistent scientific communication, the work revisits PDO-based drug sensitivity testing (DST) and proposes an expert-consensus framework for medication selection and standardized guidelines for clarification and characterization, while outlining major clinical prediction challenges.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/building-consensus-on-the-application-of-organoid-based-drug-sensitivity-testing-in-cancer-precision-medicine-and-drug-development/342888/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/building-consensus-on-the-application-of-organoid-based-drug-sensitivity-testing-in-cancer-precision-medicine-and-drug-development/342888.png","ImageObject",300,407,{"name":92,"@type":93},"Violet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of PDO-based drug sensitivity testing (DST) in this article?","Question",{"text":112,"@type":113},"It revisits the concept of PDO-based DST to standardize interpretation and strengthen scientific communication for cancer precision medicine and drug development.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the article connect PDOs to clinical decision-making?",{"text":117,"@type":113},"It presents an expert consensus-driven approach for medication selection intended to predict patient responses based on PDO-derived information.",{"name":119,"@type":110,"acceptedAnswer":120},"What types of standardization and guidance are proposed to improve PDO-based DST?",{"text":121,"@type":113},"The article proposes guidelines for clarification and characterization to further standardize PDO-based DST.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},342888,1790198445,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","Ivyspring  \nInternational Publisher  \nTheranostics  \n2024; 14(8): 3300-3316. doi: 10.7150/thno.96027  \nReview  \nBuilding consensus on the application of organoid-based drug sensitivity testing in cancer precision medicine and drug development  \nDongxi Xiang1,2\\#􀀍, Aina He3\\#, Rong Zhou4,5\\#, Yonggang Wang3\\#, Xiuying Xiao6\\#, Ting Gong7\\#, Wenyan Kang8,9\\#, Xiaolin Lin6\\#, Xiaochen Wang10\\#, PDO-based DST Consortium11, Lianxin Liu12,13􀀍, Ye-Guang Chen14,15􀀍, Shaorong Gao16,17,18􀀍, Yingbin Liu1,2􀀍  \n1. State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200232, PRC  \n2. Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, PRC  \n3. Department of Oncology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233 PRC  \n4. Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200125, PRC  \n5. National Center of Stomatology, National Clinical Research Center for Oral Disease, Shanghai 200011, PRC  \n6. Department of Oncology, Ren Ji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, PRC  \n7. Department of Oncology, Tianjin Medical University General Hospital, Tianjin 300052, PRC  \n8. Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, PRC  \n9. Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine (Boao Research Hospital), Hainan 571434, PRC  \n10. Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou, Zhejiang 310009, PRC  \n11. PDO-based DST Consortium  \n12. Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui 230001, PRC  \n13. Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, Hefei, Anhui 230001, PRC  \n14. The State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100190, PRC  \n15. The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medicine, Jiangxi Medical College, Nanchang University, Nanchang 330047, China  \n16. Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200120, PRC  \n17. Frontier Science Center for Stem Cell Research, Tongji University, 1239 Siping Road, Shanghai 200092, PRC  \n18. Shanghai Key Laboratory of Maternal-Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, PRC  \n\\#These authors contribute equally to the work.  \n􀀍 Corresponding authors: [Dongxi Xiang: dxiang@shsmu.edu.cn](Dongxi Xiang: dxiang@shsmu.edu.cn) (D.X.), Lianxin Liu: [liulx@ustc.edu.cn](liulx@ustc.edu.cn) (L.L.), Ye-[Guang Chen: ygchen@tsinghua.edu.cn](Guang Chen: ygchen@tsinghua.edu.cn) (Y-G.C.), Shaorong [Gao: gaoshaorong@tongji.edu.cn](Gao: gaoshaorong@tongji.edu.cn) (S.G.), Yingbin Liu: [laoniulyb@shsmu.edu.cn](laoniulyb@shsmu.edu.cn) (Y.L.).  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [http://ivyspring.com/terms](http://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2024.03.07; Accepted: 2024.05.09; Published: 2024.05.27  \nAbstract  \nPatient-","cbCairxgRhhMPeU5","https://ap.wps.com/l/cbCairxgRhhMPeU5","pdf",3473706,17,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"What is the main purpose of PDO-based drug sensitivity testing (DST) in this article?\",\"answer\":\"It revisits the concept of PDO-based DST to standardize interpretation and strengthen scientific communication for cancer precision medicine and drug development.\"},{\"question\":\"How does the article connect PDOs to clinical decision-making?\",\"answer\":\"It presents an expert consensus-driven approach for medication selection intended to predict patient responses based on PDO-derived information.\"},{\"question\":\"What types of standardization and guidance are proposed to improve PDO-based DST?\",\"answer\":\"The article proposes guidelines for clarification and characterization to further standardize PDO-based DST.\"}]","Building consensus on the application of organoid-based drug sensitivity testing in cancer precision medicine and drug development | PDF",1790048646,43]