[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-444612-105":59,"doc-detail-444612-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","browns-tumor-of-the-mandible-secondary-to-hyperparathyroidism","Brown’s Tumor of the Mandible Secondary to Hyperparathyroidism","","Brown’s tumor (osteitis fibrosa cystica) is a rare, non-neoplastic condition caused by hyperparathyroidism, driven by increased osteoclastic activity and bone turnover with fibrous tissue deposition. Although it typically involves long bones, it may affect facial bones, especially the mandible, and can mimic infectious, fibro-osseous, or malignant disease. A 67-year-old woman with primary HPT had an incidental mandibular swelling during extraction, with imaging showing root resorption and histology showing multinucleated giant cells. Elevated calcium and PTH confirmed diagnosis and highlighted the need for early detection to manage both the lesion and the underlying disorder.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/browns-tumor-of-the-mandible-secondary-to-hyperparathyroidism/444612/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/browns-tumor-of-the-mandible-secondary-to-hyperparathyroidism/444612.png","ImageObject",300,407,{"name":92,"@type":93},"Franzy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What causes Brown’s tumor and why can it occur in the mandible?","Question",{"text":113,"@type":114},"Brown’s tumor results from hyperparathyroidism, where excessive PTH stimulates osteoclast activity, increasing bone resorption and turnover. Although more common in long bones, facial bones—particularly the mandible—can also be affected.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How is Brown’s tumor diagnosed in this case?",{"text":118,"@type":114},"Diagnosis relied on incidental clinical findings after extraction, radiographic root resorption, and histology showing multinucleated giant cells without atypia. Elevated serum calcium and PTH supported Brown’s tumor secondary to primary HPT.",{"name":120,"@type":111,"acceptedAnswer":121},"Why is early detection important?",{"text":122,"@type":114},"Brown’s tumor is often misdiagnosed as malignant disease. Early recognition is crucial to provide appropriate treatment for the lesion and to address the underlying hyperparathyroidism.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},444612,1790766069,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":52,"preview_page_count":4},2336478945519,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Review began 11/23/2025  \nReview ended 12/05/2025  \nPublished 12/07/2025  \n© Copyright 2025  \nVlachou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98633  \nOpen Access Case Report  \nBrown’s Tumor of the Mandible Secondary to Hyperparathyroidism  \nKaterina Vlachou 1, Shoney Bivin 2, Richard Burnham 2  \n1. Oral and Maxillofacial Surgery, Manchester Royal Infirmary, Manchester, GBR 2. Oral and Maxillofacial Surgery, Royal Stoke University Hospital, Stoke-on-Trent, GBR  \nCorresponding author: Katerina Vlachou, [katerina.vlachou@nhs.net](katerina.vlachou@nhs.net)  \nAbstract  \nBrown’s tumor (osteitis fibrosa cystica) is a rare, non-neoplastic condition resulting from hyperparathyroidism (HPT) . It is characterized by increased osteoclastic activity and bone turnover, which subsequently leads to the deposition of fibrous tissue. Although it generally affects long bones of the body, it can also affect facial bones, particularly the mandible. It can further mimic other fibro-osseous, infective, or malignant conditions. We report the case of a 67-year-old female patient with primary HPT. The initial swelling was found incidentally during an extraction. Radiographic imaging revealed root resorption of the adjacent teeth, while histological examination demonstrated the typical multinucleated giant cells. Elevated serum calcium and parathyroid hormone (PTH) levels confirmed the diagnosis of primary HPT and supported the clinical impression of a Brown 's tumor. Brown 's tumor is often a diagnostic challenge as it is misdiagnosed, particularly as a malignant lesion. Early detection is crucial in order to provide the appropriate treatment, not only for the lesions but also for the underlying HPT.  \nCategories: Endocrinology/Diabetes/Metabolism, Oral Medicine  \nKeywords: brown’s tumour, mandible bone tumour, oral manifestation, primary hyperparathyroidism (phpt), surgical case reports  \nIntroduction  \nBrown’s tumor (osteitis fibrosa cystica) is a benign lesion in the bones resulting from a high osteoclast turnover rate, secondary to hyperparathyroidism (HPT) . Excessive production of the parathyroid hormone (PTH) disrupts calcium homeostasis. In bones, specifically, PTH stimulates the action of osteoclasts, resulting in the increased rate of resorption of the matrix, increasing the amount of free calcium ions in theserum. The lesions tend to resolve by treating the underlying HPT [1] .  \nPTH has a key role in regulating calcium homeostasis through its effects on both the renal and skeletal systems. PTH acts on the kidneys as a calcitonin antagonist by stimulating calcium reabsorption and inhibiting phosphate reabsorption. In the skeletal system, it stimulates osteoclast activity to release calcium ions into the circulation. Primary HPT arises from autonomous increased production of PTH from the parathyroid gland, with the most common cause being benign adenomas. Secondary HPT is a compensatory mechanism due to systemic calcium dysregulation. Hypocalcemia caused by conditions such as chronic kidney disease and vitamin D deficiency increases the production of PTH. The compensatory mechanism results in increased bone turnover [1] .  \nBrown’s tumors secondary to HPT are relatively rare, with incidence rates around 2%-5% within the population affected by the condition. It is characterized by the proliferation of giant cell granulomas and most often affects the phalanges, clavicles, ribs, and pelvic girdle, but can, in some rarer cases, affect craniofacial bones [2] . Our case reports the development of Brown’s tumor on the anterior mandible region.  \nThis article was previously presented as a poster at the JTG (Junior Trainees Group of BAOMS) Conference 2025 on November 8, 2025. This article was previously posted to th","cbCaipTMpLDk9DH7","https://ap.wps.com/l/cbCaipTMpLDk9DH7","pdf",2074699,"English","# Abstract\n# Introduction\n# Case Presentation\n## Clinical Findings\n## Surgical and Diagnostic Workup\n## Definitive Management","[{\"question\":\"What causes Brown’s tumor and why can it occur in the mandible?\",\"answer\":\"Brown’s tumor results from hyperparathyroidism, where excessive PTH stimulates osteoclast activity, increasing bone resorption and turnover. Although more common in long bones, facial bones—particularly the mandible—can also be affected.\"},{\"question\":\"How is Brown’s tumor diagnosed in this case?\",\"answer\":\"Diagnosis relied on incidental clinical findings after extraction, radiographic root resorption, and histology showing multinucleated giant cells without atypia. Elevated serum calcium and PTH supported Brown’s tumor secondary to primary HPT.\"},{\"question\":\"Why is early detection important?\",\"answer\":\"Brown’s tumor is often misdiagnosed as malignant disease. Early recognition is crucial to provide appropriate treatment for the lesion and to address the underlying hyperparathyroidism.\"}]","Brown’s Tumor of the Mandible Secondary to Hyperparathyroidism | PDF",1790708673]