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GEROSCIENCE TO THE BEDSIDE:  \nLEVERAGING BIOMARKERS OF AGING IN CLINICAL  \nRESEARCH  \nSara LaHue, University of California, San Francisco, San Francisco, California, United States  \nBiomarkers of aging, including epigenetic and proteomic “clocks”and senescence-associated secretory phenotype (SASP) factors, offer powerful tools for potentially understanding and predicting outcomesin older adults, yet their application in patient-facing clinical research remains limited. In this talk, I will share practical lessons from integrating geroscience markers into patient cohorts, focusing on delirium and other complications that follow traumatic injuries in older adults, to show how aging biomarkers may both illuminate mechanisms of vulnerability and serve as predictors of adverse clinical outcomes. I will highlight strategies for measuring these markers in clinical settings and overcoming implementation challenges to demonstrate that geroscience biomarkers are not only feasible to integrate but also essential for advancing precision approaches to aging-related conditions.","cbCaij07rj59itBw","https://ap.wps.com/l/cbCaij07rj59itBw","pdf",464263,"English","# Abstract\n## Key tools: biomarkers, epigenetic/proteomic clocks, SASP\n## Clinical focus: delirium and complications after trauma\n## Practical integration: measurement strategies and implementation challenges","[{\"question\":\"What biomarkers of aging are highlighted for clinical research in older adults?\",\"answer\":\"The talk highlights epigenetic and proteomic “clocks” and senescence-associated secretory phenotype (SASP) factors as tools to understand and predict outcomes in older adults.\"},{\"question\":\"Which clinical outcome areas are emphasized for integrating these biomarkers?\",\"answer\":\"Integration is emphasized for delirium and other complications that follow traumatic injuries in older adults.\"},{\"question\":\"How does the talk address measuring biomarkers and challenges in clinical settings?\",\"answer\":\"It shares strategies for measuring these markers in clinical settings and discusses ways to overcome implementation challenges to support feasibility and impact.\"}]","BRINGING GEROSCIENCE TO THE BEDSIDE: LEVERAGING BIOMARKERS OF AGING IN CLINICAL RESEARCH | PDF",1790634465]