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The article presents a case of breast metastasis originating from lung adenocarcinoma, emphasizing diagnostic separation from primary breast carcinoma through clinical context, imaging findings, histological assessment, and immunohistochemistry. 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Front. Oncol. 14:1370453 .  \ndoi: 10.3389/fonc.2024.1370453  \nCOPYRIGHT  \n© 2024 Ding, Gu, Yang, Lu and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nBreast metastasis from lung adenocarcinoma: a case report and review of the literature  \nJialing Ding, Huayan Gu, Zhi Yang, Yiqiao Lu and Guilong Guo*  \nDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China  \nLung cancer (LC) is one of the most lethal and most prevalent malignant tumors, and lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer . Breast cancer (BC) is the most common cancer worldwide, but metastases to the breast from extramammary neoplasms are rare, especially from the lung. Early diagnosis and differentiation of primary from metastatic breast carcinoma are essential. Here, we present a case of metastases to the breast from lung adenocarcinoma, the treatment options varied according to disease progression.  \nKEYWORDS  \nlung cancer, breast metastasis, breast cancer, diagnosis, differentiation  \nIntroduction  \nFemale breast cancer has overtaken lung cancer as the most common diagnosed cancer worldwide (1). According to the statistics of the American Cancer Society (2), lung cancer has occupied the first place of cancer deaths (21% in both sexes), and breast cancer is second only to lung cancer in women. However, metastases to the breast from extramammary neoplasms are not very common (3) . Koch et al. conducted a statistical analysis of 463 cases and obtained a proportion of breast metastases incidence from primary cancers rate: melanoma (29.8%), bronchial lung cancer (16.4%), gynecological cancer (12.7%), gastrointestinal cancer (9.9%), leukemia and lymphoma (8.4%), sarcoma (7.3%), and renal cancer (1.5%) . Differentiating between primary breast cancer and breast metastases is a challenge, particularly when the metastases are identified as lung adenocarcinoma. At present, the main means include clinical manifestation, imaging characteristics, histological examination, and immunohistochemistry testing (IHC) . The choice of combination treatment for primary and metastatic breast cancer is also different depending on the primary focus and pathology. Here, we present a case of metastases to the breast from lung adenocarcinoma and its treatment.  \nFrontiers in Oncology 01 [frontiersin.org](frontiersin.org)  \nCase report  \nIn February 2019, a 52-year-old woman with no history of smoking attended to our hospital complaining of recurring chest distress. Computed tomography (CT) scan revealed an abnormal mass and pleural effusion in her left lung. Subsequently, she underwent pleuroscopy and biopsy. Based on epidermal growth factor receptor (EGFR) mutational analysis, the specimen retrieved at pleuroscopy was identified as pulmonary adenocarcinoma with a mutation in exon-19 19-Del of the EGFR gene. Then, she received icotinib (125 mg orally three times daily) for therapy. However, 1 year late","cbCaissjrWFC2H7P","https://ap.wps.com/l/cbCaissjrWFC2H7P","pdf",578163,"English","# Introduction\n# Case report\n# Discussion","[{\"question\":\"Why is differentiating primary breast cancer from metastatic breast carcinoma important?\",\"answer\":\"Early diagnosis and accurate differentiation determine the correct treatment strategy. The article highlights that breast metastasis from extramammary tumors is rare and can be difficult to distinguish, especially when the metastatic lesion resembles lung adenocarcinoma.\"},{\"question\":\"What diagnostic methods are used to identify lung adenocarcinoma metastasis to the breast?\",\"answer\":\"The document states that clinical manifestations, imaging characteristics, histological examination, and immunohistochemistry testing (IHC) are used. It also describes additional IHC markers such as TTF-1 and Napsin-A to support lung origin.\"},{\"question\":\"How does treatment change as the disease progresses in the reported case?\",\"answer\":\"The case describes initial targeted therapy, development of resistance with subsequent switching to another targeted agent, then chemotherapy after further progression, followed by therapy adjusted after breast lesions were detected and confirmed as metastatic.\"}]","Breast metastasis from lung adenocarcinoma - a case report and review of the literature | PDF",1790041276,13]