[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-330001-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-330001-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","brca-mutation-status-and-pathological-characterization-of-breast-cancer-in-zhoushan-islands-china","BRCA mutation status and pathological characterization of breast cancer in Zhoushan Islands, China","","Objective: Investigate BRCA1/2 gene mutations and their association with clinicopathological features in breast cancer patients from Zhoushan Islands. Methods: Use high-throughput whole-exome gene sequencing to detect BRCA1/2 mutations in 776 patients. Results: BRCA1/2 mutation rate is 4.38% (34/776); BRCA1 mutations correlate with age, molecular type, and family history, while BRCA2 mutations are most common in invasive lobular carcinoma. Conclusion: Findings link BRCA1 alterations with key clinical factors in this Chinese cohort.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/brca-mutation-status-and-pathological-characterization-of-breast-cancer-in-zhoushan-islands-china/330001/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/brca-mutation-status-and-pathological-characterization-of-breast-cancer-in-zhoushan-islands-china/330001.png","ImageObject",300,407,{"name":42,"@type":43},"Logic","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the objective of the study on Zhoushan Islands breast cancer patients?","Question",{"text":63,"@type":64},"To investigate BRCA1/2 gene mutations and examine how they relate to clinicopathological features in patients from Zhoushan Islands.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were BRCA1/2 mutations detected in the study?",{"text":68,"@type":64},"High-throughput whole-exome gene sequencing was used to detect BRCA1/2 mutations after collecting blood samples.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the key results regarding BRCA1/2 mutation rates and associations?",{"text":72,"@type":64},"The BRCA1/2 mutation rate was 4.38% (34/776). BRCA1 mutations correlated with age, molecular type, and family history, while BRCA2 mutations were most common in invasive lobular carcinoma.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},330001,1790624764,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":55,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":115,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","BRCA mutation status and pathological characterization of breast cancer in Zhoushan Islands, China  \nShuhui Bao 1,2, Nini Sun 1, Yaling Li 1, Jiaojie Shu 1, Jing Xu 1, Yong Zhang 1 and Xia Qiu 1   \nJournal of International Medical Research 2024, Vol. 52(1) 1–9! The Author(s) 2024 Article reuse guidelines:  \n[sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/03000605231223426](DOI: 10.1177/03000605231223426)[ ](DOI: 10.1177/03000605231223426)[journals.sagepub.com/home/imr](journals.sagepub.com/home/imr)  \nAbstract  \nObjective: To investigate BRCA1/2 gene mutations and their relationship with clinicopathological features in patients with breast cancer in Zhoushan Islands.  \nMethods: High-throughput whole-exome gene sequencing was used to detect BRCA1/2 mutations in 776 breast cancer patients in Zhoushan Islands.  \nResults: The BRCA1/2 mutation rate of breast cancer patients in Zhoushan Islands was 4.38%(34/776). BRCA1 mutations were significantly correlated with age, molecular type, and family history of breast and ovarian cancers. BRCA2 mutations were most commonly found in invasive lobular carcinoma. Moreover, the BRCA2 mutation rate of cancers with molecular type luminal B (receptor protein–tyrosine kinase [HER2]-negative) was also relatively high.  \nConclusion: The rate of BRCA1/2 mutations in breast cancer patients from Zhoushan Islands is approximately 4.38%, and BRCA1 mutation is related to age, molecular type, and family history of breast and ovarian cancers.  \nKeywords  \nBreast cancer, pathological characterization, BRCA1/2 gene, mutation, next-generation sequencing, China  \nDate received: 31 May 2023; accepted: 11 December 2023  \n1 Surgery Department, Zhoushan Hospital of Traditional Chinese Medicine, Zhejiang, China  \n2Department of Breast Surgery, Zhoushan Hospital, Zhejiang, China  \nCorresponding author:  \nXia Qiu, Breast Surgery Department, Zhoushan Hospital, 739 Dingshen Rd, Lincheng, Dinghai, Zhoushan, Zhejiang 316021, China.  \nEmail: [qiuxia5630@sina.com](qiuxia5630@sina.com)  \nCreative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative  \nCommons Attribution-NonCommercial 4.0 License ([https://creativecommons.org/licenses/by-nc/4.0/](https://creativecommons.org/licenses/by-nc/4.0/)) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ([https://us.sagepub.com/en-us/nam/open-access-at-sage](https://us.sagepub.com/en-us/nam/open-access-at-sage)).  \nIntroduction  \nIn China, breast cancer is the most common cancer in women.1 BRCA1/2 gene mutations can be detected in more than 25% of hereditary breast cancer cases, and account for 5% to 10% of all breast cancers.2 At most, pathogenic mutations of BRCA1 and BRCA2 raise the risk of ovarian cancer by 54% and 19%, and of breast cancer by 78% and 56%, respectively.3 These genes are also related to many other malignancies4–6 such as fallopian tube cancer,7 endometrial cancer,8 melanoma,9 and colorectal cancer.10 Genetic testing for pathogenic BRCA1 and BRCA2 variants is strongly recommended for women with a personal or family history of breast, ovarian, fallopian tube, or peritoneal cancer. Moreover, prophylactic bilateral salpingooophorectomy is recommended for women with pathogenic BRCA1/2 pathogenic variants; the procedure reduces the risk of ovarian cancer by more than 80% .11  \nBRCA1/2 expression status not only guides the prevention and screening methods for breast cancer, but also determines treatment and prognosis. Notably, BRCA mutation rates are inconsistent across different ethnic populations. Studies have indicated lower BRCA mutation rates in Asians than in Caucasians in Western countries.12–15 It is thus critical to investigate BRCA variations in different ethnic populations to improve cancer risk management in thes","cbCaikJBBKuKJ70K","https://ap.wps.com/l/cbCaikJBBKuKJ70K","pdf",363424,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Materials and methods\n## Study participants and data collection\n## Molecular classification of breast cancer\n## Ethical approval and consent\n## BRCA1/2 gene variant detection and analysis","[{\"question\":\"What was the objective of the study on Zhoushan Islands breast cancer patients?\",\"answer\":\"To investigate BRCA1/2 gene mutations and examine how they relate to clinicopathological features in patients from Zhoushan Islands.\"},{\"question\":\"How were BRCA1/2 mutations detected in the study?\",\"answer\":\"High-throughput whole-exome gene sequencing was used to detect BRCA1/2 mutations after collecting blood samples.\"},{\"question\":\"What were the key results regarding BRCA1/2 mutation rates and associations?\",\"answer\":\"The BRCA1/2 mutation rate was 4.38% (34/776). BRCA1 mutations correlated with age, molecular type, and family history, while BRCA2 mutations were most common in invasive lobular carcinoma.\"}]","BRCA mutation status and pathological characterization of breast cancer in Zhoushan Islands, China | PDF",1789986499,23]