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Previous research linked higher visceral fat to atrophy in regions vulnerable to early AD pathology. This study examined how high visceral fat and type 2 diabetes mellitus jointly relate to brain volume loss, a key biomarker of neurodegeneration.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/brain-structure-in-type-2-diabetics-with-high-visceral-adiposity-poster-presentation-abstract/468444/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/brain-structure-in-type-2-diabetics-with-high-visceral-adiposity-poster-presentation-abstract/468444.png","ImageObject",300,407,{"name":92,"@type":93},"\tJames","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main background for this study on brain structure?","Question",{"text":112,"@type":113},"Dementia, including Alzheimer’s Disease, is preventable through modifiable risk factors. Higher visceral fat has been associated with atrophy in brain regions vulnerable to early AD pathology.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the study conducted and what imaging was used?",{"text":117,"@type":113},"A cross-sectional study included 4,213 adults who underwent whole-body MRI at 1.5T across multiple sites. Visceral and subcutaneous adipose tissue were quantified, and deep learning measured visceral fat and brain volumes from regional segmentations.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key findings regarding brain volumes in type 2 diabetics with high visceral adiposity?",{"text":121,"@type":113},"Participants with type 2 diabetes and the highest quartile of visceral adipose tissue had significantly lower brain parenchymal volumes, reduced hippocampal volume, and decreased posterior cingulate gyrus volume, while precuneus showed no significant difference.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},468444,1790774241,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":24,"preview_page_count":4},2336474466412,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","DOI: 10. 1002/alz70856_106639  \nBIOMARKERS  \nPOSTER PRESENTATION  \nNEUROIMAGING  \nBrain Structure in Type 2 Diabetics with High Visceral Adiposity  \nCyrus A. Raji1  Somayeh Meysami2, 3  Soojin Lee4  Saurabh Garg4  Nasrin Akbari4  Rodrigo Solis Pompa4  Ahmed Gouda4  Thanh Duc Nguyen4 Saqib Basar4  Yosef Gavriel Chodakiewitz5  David A. Merrill2, 3  Amar Patel5 Daniel J. Durand5  Sam Hashemi4  \n1 Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA  \n2 Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA  \n3Saint John’s Cancer Institute at Providence Saint John’s Health Center, Santa Monica, CA, USA  \n4Vigilance Health Imaging Network Inc., Vancouver, BC, Canada  \n5 Prenuvo, Palo Alto, CA, USA  \nCorrespondence  \nCyrus A. Raji, Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.  \n[Email:](Email: craji@wustl.edu)[ craji@wustl.edu](Email: craji@wustl.edu)  \nAbstract  \nBackground: Dementia, including Alzheimer’s Disease (AD), is preventable, with modifiable risk factors accounting for up to 45% of cases. Previous research has shown that higher visceral fat is related to atrophy in brain regions vulnerable to early AD pathology, such as the hippocampus and posterior cingulate gyrus. This study investigated the confluence of high visceral fat with type 2 diabetes mellitus on brain volume loss, a critical biomarker of neurodegeneration.  \nMethod: A cross-sectional study of 4,213 adults (mean age 55.39 ± 12.84 years, 57.3% women) underwent whole-body MRI at 1.5T across sites in Vancouver, Canada; San Francisco Bay Area, California; and Minneapolis, Minnesota. Scanner models included Siemens Espree and Aera. The protocol included whole-body sagittal T1-and T2-weighted images, coronal STIR, and axial T1 images with Dixon technique, enabling visual identification and quantification of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Deep learning models measured visceral fat and brain volumes computed from regional segmentations using Fastsurfer. Type 2 diabetes mellitus history was obtained through participant self-report. Brain volumes in brain parenchyma, hippocampus, posterior cingulate, and precuneus were compared in diabetics with the highest quartile of VAT (n = 144) to those without, using ANCOVA adjusted for age, sex, and total intracranial volume.  \nResult: Persons with type 2 diabetes mellitus were significantly older (mean age 61.5 ± 11. 3 years; p \u003C.001), more likely to be obese (mean BMI 33.3 ± 5.8; p \u003C.001), and predominantly male (71%; p \u003C.001). Type 2 diabetics with the highest quartile of VAT showed significantly lower brain parenchymal volumes (F=632, p \u003C.0001), reduced hippocampal volume (Figure 1A; F=376. 2, p = .012), and decreased posterior cingulate gyrus volume (Figure 1B; F=336. 9, p = .000013). No significant difference was observed in precuneus volume (p = . 54).  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.  \nAlzheimer’s Dement. 2025;21(Suppl. 2):e106639.  \n[https://doi.org/10.1002/alz70856_106639](https://doi.org/10.1002/alz70856_106639)  \nwi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz)  \n1of2  \nBIOMARKERS  \nConclusion: Individuals with type 2 diabetes mellitus and higher amounts of visceral fat exhibited lower volumes in whole brain parenchyma and regions vulnerable to Alzheimer’s disease. These findings suggest that type 2 diabetes and visceral obesity may be important targets for secondary prevention of AD as early as midlife. The public health implications are significant, as these conditions are modifiable through behavioral and pharmacological intervent","cbCaiihSM9sb0PRN","https://ap.wps.com/l/cbCaiihSM9sb0PRN","pdf",250728,"English","# Abstract\n## Background\n## Method\n## Result\n## Conclusion","[{\"question\":\"What is the main background for this study on brain structure?\",\"answer\":\"Dementia, including Alzheimer’s Disease, is preventable through modifiable risk factors. Higher visceral fat has been associated with atrophy in brain regions vulnerable to early AD pathology.\"},{\"question\":\"How was the study conducted and what imaging was used?\",\"answer\":\"A cross-sectional study included 4,213 adults who underwent whole-body MRI at 1.5T across multiple sites. Visceral and subcutaneous adipose tissue were quantified, and deep learning measured visceral fat and brain volumes from regional segmentations.\"},{\"question\":\"What were the key findings regarding brain volumes in type 2 diabetics with high visceral adiposity?\",\"answer\":\"Participants with type 2 diabetes and the highest quartile of visceral adipose tissue had significantly lower brain parenchymal volumes, reduced hippocampal volume, and decreased posterior cingulate gyrus volume, while precuneus showed no significant difference.\"}]","Brain Structure in Type 2 Diabetics with High Visceral Adiposity - Poster Presentation - Abstract | PDF"]