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Methods: Behavioral neuroscores were assessed daily for up to 7 days after SAH using the endovascular perforation model in mice across five studies, with histology in a subset. Results: Overall DND incidence was 33.9% with higher rates in females, and delayed death occurred in 21.1%. Conclusions: DND rates in this mouse model match human observations, supporting murine testing of DCI therapies, with future work linking DND to regional cerebral blood flow.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/brain-hemorrhages-5-incidence-and-factors-in-delayed-neurological-deficits-after-subarachnoid-hemorrhage-in-mice/510844/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/brain-hemorrhages-5-incidence-and-factors-in-delayed-neurological-deficits-after-subarachnoid-hemorrhage-in-mice/510844.png","ImageObject",300,407,{"name":42,"@type":43},"Dipper","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-12","2026-10-06",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",14,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main clinical problem addressed in this article?","Question",{"text":63,"@type":64},"The article focuses on delayed cerebral ischemia (DCI) and its delayed neurological deficits (DND) after aneurysmal subarachnoid hemorrhage (SAH). DCI is described as a major cause of morbidity in patients who survive to definitive aneurysm treatment.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were delayed neurological deficits measured in the mouse studies?",{"text":68,"@type":64},"Daily behavioral performance was assessed from day 1 through up to 7 days after SAH using an 8-test sensorimotor neuroscore. The neuroscore was used to identify the incidence and timing of DND as a clinical surrogate for DCI.",{"name":70,"@type":61,"acceptedAnswer":71},"What incidence rates of DND and delayed death were reported?",{"text":72,"@type":64},"The overall incidence of DND was 33.9%, and delayed death occurred in 21.1%. The study reports no statistically significant sex differences for delayed mortality and DND incidence.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},510844,1791831454,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":111,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":118,"preview_page_count":4},1374404997633,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Brain Hemorrhages 5 (2024) 99–106  \nContents lists available at ScienceDirect  \nBrain Hemorrhages  \njournal [homepage: www. keaipublishing. com/en/journals/brain-hemorrhages/](homepage: www. keaipublishing. com/en/journals/brain-hemorrhages/)  \nResearch Article  \nIncidence and factors in delayed neurological deficits after subarachnoid hemorrhage in mice  \nWilliam Wroe a, Ari Dienel a, Sungha Hong a, Kanako Matsumura a, Jose Guzman a, Kiara Torres a, Angelica Bernalb, Hussein A. Zeineddine a, Peeyush Thankamani Pandit a, Spiros L. Blackburn a, Devin W. McBride a, ⇑, 1  \na The Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA b Cornell University, Ithaca, NY, USA  \n\n| a r t i c l e i n f o | a b s t r a c t\u003Cbr>Objective: Delayed cerebral ischemia (DCI) is one of the most feared complications in aneurysmal subarachnoid hemorrhage (SAH). Animal models are crucial to studying the disease mechanisms and potential treatments. DCI in rodents was thought to not exist; herein we examine literature and our experience with DCI in rodents.\u003Cbr>Methods: Daily behavioral performance was assessed every day from day 1 to up to 7 days post-SAH on mice from 5 different studies that used the endovascular perforation model. Performance was graded using an 8-test sensorimotor neuroscore previously described. The daily neuroscore was then used to identify the incidence and timing of delayed neurological deficits (DND), a clinical surrogate for DCI. A total number of 298 mice (134 males, 164 females) were subjected to SAH. Fifty-one mice had histological staining done to identify infarct volume.\u003Cbr>Results: The overall incidence of DND was 33.9%; 27.6% in males and 39.0% in females, but this difference was not statistically significant. The overall incidence of delayed death was 21. 1%, and there was no significant difference for delayed mortality in females versus male mice. There is a non-statistically significant trend towards increased infarct volume in mice suffering DND.\u003Cbr>Conclusions: Mice with endovascular puncture induced SAH develop DND at rates comparable to human patients. Future work needs to correlate the DND seen with decreased regional cerebral blood flow, another hallmark of DCI, but in spite of this need, researchers may use the murine models to test therapies for DCI after SAH.\u003Cbr>􀀁 2023 International Hemorrhagic Stroke Association. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license ([http://creati](http://creati)[vecommons.org/licenses/by-nc-nd/4.0/](vecommons.org/licenses/by-nc-nd/4.0/)). |\n| --- | --- |\n| Article history:\u003Cbr>Received 6 November 2023\u003Cbr>Received in revised form 16 December 2023 Accepted 20 December 2023\u003Cbr>Available online 30 December 2023 |  |\n| Keywords:\u003Cbr>Subarachnoid hemorrhage Delayed cerebral ischemia\u003Cbr>Delayed neurological deficits DCI\u003Cbr>SAH |  |\n\n1. Introduction  \nDelayed cerebral ischemia (DCI) is the most common cause of morbidity in patients with aneurysmal subarachnoid hemorrhage (SAH) who survive to having their aneurysm definitively treated.1 DCI occurs in roughly 30 % of surviving patient’s, usually within 3–14 days after their SAH onset, and often leads to cerebral infarction and delayed neurological deficits (DND).2 Initially it was  \nAbbreviations: DCI, Delayed Cerebral ischemia; SAH, Subarachnoid Hemorrhage; DND, Delayed Neurological Deficit.  \n⇑ Corresponding author at: The Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA  \nE-mail address: [devin.w.mcbride@uth.tmc.edu](devin.w.mcbride@uth.tmc.edu) (D.W. McBride).  \n1 ORCID: 0000-0001-8988-3353.  \nbelieved that DCI was directly caused by large vessel vasospasm, often referred to as angiographic vasospasm. However, multiple lines of evidence suggest that the mechanism of DCI is","cbCaiv8gLlY2Hv7Q","https://ap.wps.com/l/cbCaiv8gLlY2Hv7Q","pdf",245421,"English","# Objective\n# Methods\n# Results\n# Conclusions\n# Introduction","[{\"question\":\"What is the main clinical problem addressed in this article?\",\"answer\":\"The article focuses on delayed cerebral ischemia (DCI) and its delayed neurological deficits (DND) after aneurysmal subarachnoid hemorrhage (SAH). DCI is described as a major cause of morbidity in patients who survive to definitive aneurysm treatment.\"},{\"question\":\"How were delayed neurological deficits measured in the mouse studies?\",\"answer\":\"Daily behavioral performance was assessed from day 1 through up to 7 days after SAH using an 8-test sensorimotor neuroscore. The neuroscore was used to identify the incidence and timing of DND as a clinical surrogate for DCI.\"},{\"question\":\"What incidence rates of DND and delayed death were reported?\",\"answer\":\"The overall incidence of DND was 33.9%, and delayed death occurred in 21.1%. The study reports no statistically significant sex differences for delayed mortality and DND incidence.\"}]","Brain Hemorrhages 5 - Incidence and factors in delayed neurological deficits after subarachnoid hemorrhage in mice | PDF",1791245535]