[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-340512-105":59,"doc-detail-340512-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","body-roundness-index-trajectories-and-the-risk-of-cancer-a-cohort-study","Body Roundness Index Trajectories and the Risk of Cancer - A Cohort Study","","Background: The body rounds index (BRI) is an obesity indicator combining waist circumference with height, enabling a two-dimensional assessment of obesity; prior work has not clarified how BRI trajectory patterns relate to cancer. Methods: Using 42,022 participants observed from 2006–2010, three BRI trajectory groups (low-stable, medium-stable, high-stable) were defined and linked to cancer incidence and cancer-specific deaths with Cox regression across total, sex-, and age-specific strata, plus site-specific analyses. Results: After a median 11.04-year follow-up, high-stable BRI increased overall cancer risk versus low-stable, with stronger effects in middle-aged men and elevated risk for uterine cancers. Conclusion: High-stable BRI trajectories are significantly associated with cancer incidence and uterine site-specific cancer, supporting lifestyle modification and monitoring BRI changes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/body-roundness-index-trajectories-and-the-risk-of-cancer-a-cohort-study/340512/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/body-roundness-index-trajectories-and-the-risk-of-cancer-a-cohort-study/340512.png","ImageObject",300,407,{"name":92,"@type":93},"Evangeline","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the body roundness index (BRI) and why is it studied for cancer risk?","Question",{"text":112,"@type":113},"BRI is an obesity indicator integrating waist circumference and height to provide a two-dimensional assessment of obesity. The study investigates whether different BRI trajectory patterns are associated with cancer incidence and cancer-specific deaths.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were BRI trajectory patterns defined in this cohort study?",{"text":117,"@type":113},"BRI changes from 2006 to 2010 were used to identify three trajectory groups: low-stable, medium-stable, and high-stable. These groups were then compared for cancer outcomes.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings about cancer risk across BRI trajectories?",{"text":121,"@type":113},"After a median follow-up of 11.04 years, the high-stable BRI trajectory was associated with a higher risk of cancer occurrence compared with the low-stable trajectory. The association was especially pronounced in middle-aged men and for uterine site-specific cancers.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},340512,1790645026,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},13056703019662,"https://ap-avatar.wpscdn.com/avatar/be000253a8e92610077?_k=1778726343310543188","Cancer Medicine  \nRESEARCH ARTICLE  OPEN ACCESS   \nBody Roundness Index Trajectories and the Risk of Cancer: A Cohort Study  \nYue Chen1,2,3 | Yiming Wang4 | Xin Zheng1,2,3 | Tong Liu1,2,3 | Chenan Liu1,2,3 | Shiqi Lin1,2,3 | Hailun Xie1,2,3 | Jinyu Shi1,2,3 | Xiaoyue Liu1,2,3 | Xiangming Ma5 | Li Deng1,2,3 | Shouling Wu4 | Hanping Shi1,2,3   \n1Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing,  \nChina | 2Department of National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China | 3Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China | 4Department of Cardiology, Kailuan General Hospital, North China University of  \nScience and Technology, Tangshan, China | 5Department of Hepatological Surgery, Kailuan General Hospital, Tangshan, China Correspondence: Shouling Wu ([drwusl@163.com](drwusl@163.com)) | Hanping Shi ([shihp@ccmu.edu.cn](shihp@ccmu.edu.cn))  \nReceived: 23 May 2024 | Revised: 20 October 2024 | Accepted: 14 November 2024  \nFunding: This work was supported by National Key Research and Development Program of China (grant number 2022YFC2010101); Laboratory for Clinical Medicine, Capital Medical University (grant number 2023-SYJCLC01); National Multidisciplinary Cooperative Diagnosis and Treatment Capacity Project for Major Diseases: Comprehensive Treatment and Management of Critically Ill Elderly Inpatients (grant number 2019.YLFW) .  \nKeywords: abdominal obesity | body roundness index | cancer | epidemiology | trajectory analysis  \nABSTRACT  \nBackground: The body rounds index (BRI), an innovative obesity indicator integrating waist circumference (WC) and height, offers a two-dimensional assessment of obesity. The relationship between BRI trajectories and cancer has been overlooked in previous studies. This study aims to explore the association between BRI trajectories and the incidence of cancer.  \nMethods: This study included 42,022 participants with a median age of 48.91years. Based on the changes in participants' BRI during the period from 2006 to 2010, three BRI trajectory patterns were identified: low-stable, medium-stable, and high-stable. The primary outcome was cancer incidence and the secondary outcome was cancer-specific deaths. The association between BRI trajectories and cancer incidence and death was explored by cox regression analysis in the total, sex-specific and age-specific populations, respectively. Additionally, we further investigated the relationship between BRI and site-specific cancer incidence. Sensitivity analyses were applied to exclude interferences and ensure the stability of the results.  \nResults: After a median follow-up time of 11.04 years, high-stable BRI trajectory was significantly associated with increased risk of cancer occurrence compared to low-stable BRI trajectory. This association was more pronounced in middle-aged men (men: HR = 1.46, 95% CI = 1.21–1.77, p \u003C 0.001; age \u003C 65: HR = 11.38, 95% CI = 1.15–1.66, p = 0.001). Additionally, high-stable BRI trajectory was significantly associated with a substantial increase in the risk of site-specific uterine cancers (HR = 4.92, 95% CI = 1.69–14.33, p = 0.004). Sensitivity analysis confirmed the stability of the results.  \nConclusion: Our study identified a significant association between a high-stable BRI trajectory and cancer incidence, with this association being most pronounced in middle-aged men. Moreover, the high-stable BRI trajectory was strongly associated with uterine site-specific cancer development. Our findings underscore the importance of implementing lifestyle modifications and monitoring BRI values and their changes to provide effective health guidance.  \n\n| Yue Chen, Yiming Wang, and Xin Zheng have contributed equally to this work and share first authorship. |\n| --- |\n| This is an open access article under the terms of the Creative Commons Attribution License","cbCaiggsVqQkaSaS","https://ap.wps.com/l/cbCaiggsVqQkaSaS","pdf",431064,11,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the body roundness index (BRI) and why is it studied for cancer risk?\",\"answer\":\"BRI is an obesity indicator integrating waist circumference and height to provide a two-dimensional assessment of obesity. The study investigates whether different BRI trajectory patterns are associated with cancer incidence and cancer-specific deaths.\"},{\"question\":\"How were BRI trajectory patterns defined in this cohort study?\",\"answer\":\"BRI changes from 2006 to 2010 were used to identify three trajectory groups: low-stable, medium-stable, and high-stable. These groups were then compared for cancer outcomes.\"},{\"question\":\"What were the main findings about cancer risk across BRI trajectories?\",\"answer\":\"After a median follow-up of 11.04 years, the high-stable BRI trajectory was associated with a higher risk of cancer occurrence compared with the low-stable trajectory. The association was especially pronounced in middle-aged men and for uterine site-specific cancers.\"}]","Body Roundness Index Trajectories and the Risk of Cancer - A Cohort Study | PDF",1790036982,28]