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This multicenter prospective study developed a body mass index (BMI)-based inflammation index and evaluated its prognostic value. Among 2376 patients aged 65+, outcomes included overall survival, short-term survival, malnutrition, and cachexia, assessed with C-index, ROC analysis, Kaplan–Meier estimates, Cox regression, and subgroup validation. Results highlighted BCLR as a strong independent risk marker.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/body-mass-index-based-inflammation-index-is-a-promising-prognostic-predictor-in-older-adult-cancer-patients/356563/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/body-mass-index-based-inflammation-index-is-a-promising-prognostic-predictor-in-older-adult-cancer-patients/356563.png","ImageObject",300,407,{"name":92,"@type":93},"Jacob","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23",true,{"@type":101,"interactionType":102,"userInteractionCount":8},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What is the study’s main goal?","Question",{"text":111,"@type":112},"To develop a BMI-based inflammation index and determine its prognostic significance in older adults with cancer.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"How was patient prognosis evaluated?",{"text":116,"@type":112},"The study used C-index and ROC curves to compare indices, Kaplan–Meier survival with log-rank tests for overall survival, and Cox proportional hazards regression to identify independent predictors.",{"name":118,"@type":109,"acceptedAnswer":119},"Why is BCLR highlighted in the findings?",{"text":120,"@type":112},"BCLR showed higher ROC AUC and C-index than other inflammation indices and was significantly associated with increased mortality and worse overall survival, including in multiple cancer subgroups.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},356563,1790169453,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":138,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962084931830,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Huang et al. BMC Geriatrics (2026) 26:442 BMC Geriatrics  \n[https://doi.org/10.1186/s12877-026-07232-0](https://doi.org/10.1186/s12877-026-07232-0)  \nRESEARCH Open Access  \nBody mass index-based inflammation index is a promising prognostic predictor in older adult cancer patients  \nJia-Xin Huang1,5†, Xi Zhang1,2,3†, Min Yang1†, Meng Tang1,2,3, Qi Zhang2,3,7, Li Deng2,3,6, Chun-Hua Song4, Wei Li5, Han-Ping Shi2,3,6* and Ming-Hua Cong1*  \nAbstract  \nBackground Older patients with cancer often have a worse prognosis than the general cancer patient population due to decreased immune responses, chronic inflammation status, and malnutrition. The present study aimed to develop a novel body mass index (BMI)-based inflammation index and investigate its prognostic significance in older patients with cancer.  \nMethods This multicenter prospective study totally included 2376 cancer patients aged 65 years or older. Concordance index (C-index) and receiver operating characteristic (ROC) curves were applied to compare the prognostic value of various BMI-based inflammation indices. The overall survival (OS) was calculated and compared using the Kaplan–Meier method generated by the log-rank test. A Cox proportional hazard regression model was performed to identify independent predictors associated with OS. Subgroup analysis was used to explore the discriminative performance in different populations. The second outcomes included short-term survival, malnutrition and cachexia.  \nResults We recorded 1112 death cases during a median follow-up of 17.43 months. Both the area under ROC curvesand the C-index of the BMI to C-reactive protein/lymphocyte ratio (BCLR) were higher than other inflammation indices. There was a significant L-shaped association between BCLR and all-cause mortality in older patients with cancer (P \u003C 0. 001) . A low BCLR was significantly associated with shortened OS and served as an independent risk factor for survival in older patients with cancer (hazard ratio = 1 . 51, 95% confidence interval = 1 .32–1. 73, P \u003C 0. 001) . In the subgroup analysis, a low BCLR was an independent risk factor for prognosis inpatients with lung (HR = 1 .40, 95%CI = 1 .13–1. 73, P = 0 . 002), upper gastrointestinal (HR = 1 . 32, 95%CI = 1 .01–1. 73, P = 0 . 041), hepatobiliary and pancreatic (HR = 1 . 78, 95%CI = 1 .10–2. 88, P = 0 . 020) and colorectal cancer (HR = 2 . 24, 95%CI = 1 .57–3. 18, P \u003C 0. 001) . In addition, the prognostic value of low BCLR was also confirmed in underweight, normal as well as overweight and  \n†Jia-Xin Huang, Xi Zhang and Min Yang contributed equally to this work.  \n*Correspondence:  \nHan-Ping Shi [shihp@ccmu.edu.cn](shihp@ccmu.edu.cn)[ ](shihp@ccmu.edu.cn)Ming-Hua Cong [congmh@cicams.ac.cn](congmh@cicams.ac.cn)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/licenses/by-nc-nd/4.0/](vecommons.org/licenses/by-nc-nd/4.0/.)[.](vecommons.org/licenses/by-nc-nd/4.0/.)  \nHuang et a","cbCaim3X2ozw6p13","https://ap.wps.com/l/cbCaim3X2ozw6p13","pdf",1890580,13,"English","# Abstract\n# Background\n# Methods\n## Study design and participants\n## Statistical analyses\n# Results\n## Primary findings\n## Subgroup findings\n# Conclusion\n# Keywords","[{\"question\":\"What is the study’s main goal?\",\"answer\":\"To develop a BMI-based inflammation index and determine its prognostic significance in older adults with cancer.\"},{\"question\":\"How was patient prognosis evaluated?\",\"answer\":\"The study used C-index and ROC curves to compare indices, Kaplan–Meier survival with log-rank tests for overall survival, and Cox proportional hazards regression to identify independent predictors.\"},{\"question\":\"Why is BCLR highlighted in the findings?\",\"answer\":\"BCLR showed higher ROC AUC and C-index than other inflammation indices and was significantly associated with increased mortality and worse overall survival, including in multiple cancer subgroups.\"}]","Body mass index-based inflammation index is a promising prognostic predictor in older adult cancer patients | PDF",1790125973,33]