[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-436742-105":59,"doc-detail-436742-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","blood-prestin-levels-in-covid-19-patients","Blood prestin levels in COVID-19 patients","","Study evaluates serum prestin levels in individuals with COVID-19 and compares them with healthy volunteers, aiming to assess infection severity and whether additional tissues are involved. Blood samples from 45 COVID-19 patients and 40 controls were analyzed for prestin via enzyme-linked immunosorbent assay, alongside LDH, CRP, ALT, AST, CK-MB, ferritin, and D-dimer. COVID-19 patients showed significantly higher prestin and strong positive correlations with CRP and D-dimer.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/blood-prestin-levels-in-covid-19-patients/436742/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/blood-prestin-levels-in-covid-19-patients/436742.png","ImageObject",300,407,{"name":92,"@type":93},"Sarah ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How were prestin levels measured in COVID-19 patients?","Question",{"text":112,"@type":113},"Serum prestin levels were determined from blood samples using a commercially available enzyme-linked immunosorbent assay (ELISA) kit.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is the main finding regarding prestin levels?",{"text":117,"@type":113},"Serum prestin levels in COVID-19 patients were significantly higher than in healthy controls (p \u003C 0.001).",{"name":119,"@type":110,"acceptedAnswer":120},"With which biomarkers did prestin show positive correlations?",{"text":121,"@type":113},"Prestin correlated positively with CRP and D-dimer, with statistically significant strong positive correlations reported in the results.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436742,1790878317,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962085320529,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","J Chin MedAssoc  \nOriginal article  \nBlood prestin levels in COVID-19 patients  \nMahfuz Turana,* , Hamit Hakan Alpb, Hanifi Yildizc, Ali İrfan Barand, Selami Ekinc, Ramazan Akına, Ahmet Arısoyc, Yaser Said Çetina, Aydın Turana, Nazım Bozana  \naDepartment of Otorhinolaryngology, Medical Faculty, Yuzuncu Yıl University, Van, Turkey; bDepartment of Biochemistry, Medical Faculty, Yuzuncu Yıl University, Van, Turkey; cDepartment of Pulmonary Medicine, Medical Faculty, Yuzuncu Yıl University, Van, Turkey; dDepartment of Infectious Diseases and Clinical Microbiology, Medical Faculty, Yuzuncu Yıl University, Van, Turkey  \nAbstract  \nBackground: Many studies have found that viral infections affect different tissues, including the inner ear. Coronavirus disease 2019 (COVID-19), a viral infection, is a significant health problem worldwide. Prestin is a motor protein with important functions both in the outer hair cells of the inner ear and in cardiac tissue. In addition, prestin is promising as an early biomarker in the detection of ototoxicity. To determine the severity of infection in COVID-19 patients and to determine whether other tissues are affected by the infection, lactate dehydrogenase (LDH), C-reactive protein (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase MB (CK-MB), biochemical markers such as ferritin and D-dimer are used. This study aimed to compare prestin levels in patients with COVID-19 and healthy volunteers.  \nMethods: In blood samples taken from 45 patients diagnosed with COVID-19 and 40 healthy volunteers, prestin levels were determined with the kit that used an enzyme-linked immunosorbent assay method and was commercially available. At the sametime, LDH, CRP, ALT, AST, CK-MB, ferritin, and D-dimer levels were also detected in both patients and healthy control groups and correlations with prestin levels were examined.  \nResults: The main result of our study is that serum prestin levels in COVID-19 patients are significantly higher than in healthy controls (p \u003C 0.001) . In addition, a statistically significant strong positive correlation was found between prestin-LDL (r = 0.537, p = 0.001), prestin-CRP (r = 0.654, p = 0.001), and prestin-D-dimer (r = 0.659, p = 0.001) .  \nConclusion: The levels of prestin, a motor protein in inner ear outer hair cells and cardiac myocytes, were found to be higher in COVID-19 patients than in healthy volunteers. It also showed a positive correlation with CRP and D-dimer. This may be associated with systemic dysfunction.  \nKeywords: Cardiac myocytes; Cochlear outer hair cells; COVID-19; Prestin  \n1. INTRODUCTION  \nCoronavirus disease 2019 (COVID-19) is a severe infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) . After the first case was reported in Wuhan, China, in December 2019, cases began to be seen worldwide, and a few months later, COVID-19 was declared a pandemic by the World Health Organization (WHO) on March 11, 2020.1 From the first case to the present day, more than 5.5 million people have died due to COVID-19 .2 COVID-19 is characterized by an abnormal host immune response that causes an extreme inflammatory response or cytokine storm.3 It has been reported to cause multiple-organ failure, especially in the respiratory system.4 Effective vaccines have been developed for COVID-19, but variants have emerged over time due to mutations, so its virulence continues.  \n*Address correspondence. Dr. Mahfuz Turan, Department of Otorhinolaryngology, Medical Faculty, Yuzuncu Yıl University, 65400, Van, Turkey. E-mail address: [mahfuzturan@hotmail.com](mahfuzturan@hotmail.com) (M. Turan).  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2023) 86: 571-576.  \nReceived June 15, 2022; accepted February 16, 2023.  \ndoi: 10. 1097/JCMA.0000000000000919.  \nCopyright © 2023, the ","cbCaickh3oUPtfnZ","https://ap.wps.com/l/cbCaickh3oUPtfnZ","pdf",542298,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# 1. INTRODUCTION","[{\"question\":\"How were prestin levels measured in COVID-19 patients?\",\"answer\":\"Serum prestin levels were determined from blood samples using a commercially available enzyme-linked immunosorbent assay (ELISA) kit.\"},{\"question\":\"What is the main finding regarding prestin levels?\",\"answer\":\"Serum prestin levels in COVID-19 patients were significantly higher than in healthy controls (p \\u003c 0.001).\"},{\"question\":\"With which biomarkers did prestin show positive correlations?\",\"answer\":\"Prestin correlated positively with CRP and D-dimer, with statistically significant strong positive correlations reported in the results.\"}]","Blood prestin levels in COVID-19 patients | PDF",1790678902,15]