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Prior studies in men have reported inconsistent associations, motivating a prospective cohort investigation. Involving 2956 men, blood Cd was quantified and participants were followed for 78 months for cancer outcomes. High blood Cd (>0.71 µg/L) corresponded to increased cancer risk versus low levels (\u003C0.19 µg/L), with elevated hazard ratios in key subgroups. Smoking did not significantly modify the association. Findings suggest blood Cd may help indicate cancer risk and support Cd exposure minimization, while verification in other populations remains necessary for prevention.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/blood-cadmium-level-is-a-marker-of-cancer-risk-in-men/330593/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/blood-cadmium-level-is-a-marker-of-cancer-risk-in-men/330593.png","ImageObject",300,407,{"name":92,"@type":93},"Eliana","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the study evaluate regarding cadmium and cancer risk in men?","Question",{"text":112,"@type":113},"It assesses whether blood cadmium (Cd) level serves as a marker for cancer risk in men, especially at lower concentrations where evidence has been limited.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the study designed and how long were participants followed?",{"text":117,"@type":113},"A prospective cohort study enrolled 2956 men and followed them for 78 months to measure incident cancer outcomes after blood Cd measurement.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main results comparing high versus low blood Cd levels?",{"text":121,"@type":113},"Men with high blood Cd (>0.71 µg/L) had a significantly increased cancer risk compared with those with low levels (\u003C0.19 µg/L), with hazard ratios notably higher in several subgroups.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330593,1790755100,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","nutrients   \nCommunication  \nBlood Cadmium Level Is a Marker of Cancer Risk in Men  \nRóa Derkacz 1, Wojciech Marciniak 1, Piotr Baszuk 2, Monika Wysoki ´nska 2, Natalia Chrzanowska 2, Marcin Lener 2, Tomasz Huzarski 2,3, Jacek Gronwald 2, Tadeusz D˛ebniak 2, Cezary Cybulski 2, Anna Jakubowska 2, Rodney J. Scott 4,5 and Jan Lubi ´nski 1,2, *  \nCitation: Derkacz, R.; Marciniak, W.; Baszuk, P.; Wysoki ´nska, M.;  \nChrzanowska, N.; Lener, M.; Huzarski, T.; Gronwald, J.; D˛ebniak, T.; Cybulski, C.; et al. Blood Cadmium Level Is a Marker of Cancer Risk in Men. Nutrients 2024, 16, 1309 . [https://doi.org/10.3390/nu16091309](https://doi.org/10.3390/nu16091309)  \nAcademic Editor: Antonio Brunetti  \nReceived: 10 April 2024  \nRevised: 18 April 2024  \nAccepted: 21 April 2024  \nPublished: 27 April 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Read-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Dobra, Poland; [roza.derkacz@read-gene.com](roza.derkacz@read-gene.com) (R.D.); [wojciech.marciniak@read-gene.com](wojciech.marciniak@read-gene.com) (W.M.)  \n2 Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland; [piotr.baszuk@pum.edu.pl](piotr.baszuk@pum.edu.pl) (P.B.); [monika.wysokinska@pum.edu.pl](monika.wysokinska@pum.edu.pl) (M.W.); [natalia.chrzanowska@pum.edu.pl](natalia.chrzanowska@pum.edu.pl) (N.C.); [marcin.lener@pum.edu.pl](marcin.lener@pum.edu.pl) (M.L.); [tomasz.huzarski@pum.edu.pl](tomasz.huzarski@pum.edu.pl) (T.H.); [jacek.gronwald@pum.edu.pl](jacek.gronwald@pum.edu.pl) (J.G.); [tadeusz.debniak@pum.edu.pl](tadeusz.debniak@pum.edu.pl) (T.D.); [cezarycy@pum.edu.pl](cezarycy@pum.edu.pl) (C.C.); [anna.jakubowska@pum.edu.pl](anna.jakubowska@pum.edu.pl) (A.J.)  \n3 Department of Clinical Genetics and Pathology, University of Zielona Góra, ul. Zyty 28, 65-046 Zielona Góra, Poland  \n4 School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW 2308, Australia; [rodney.scott@newcastle.edu.au](rodney.scott@newcastle.edu.au)  \n5 Division of Molecular Medicine, NSW Health Pathology North, Newcastle, NSW 2064, Australia  \n* [Correspondence: jan.lubinski@pum.edu.pl](Correspondence: jan.lubinski@pum.edu.pl); Tel.: +48-91-441-72-50  \nAbstract: Cadmium (Cd) is a known carcinogen, but its impact on cancer risk at lower concentrations is poorly understood. Previous studies on Cd and cancer risk in men show inconsistent results, prompting further investigation. A prospective cohort study involving 2956 men was conducted. Blood Cd levels were measured, and participants were followed for 78 months to assess cancer incidence. Men with high blood Cd levels (>0.71 µg/L) had a significantly increased risk of cancer compared to those with low levels (\u003C0.19 µg/L) (HR 3.42, p \u003C 0.001), particularly among non-smokers (HR 3.74, p = 0.003), individuals aged \u003C 60 years (HR 2.79, p = 0.017), and ≥60 (HR 4.63, p = 0.004) . The influence of smoking on cancer risk based on Cd levels was not significant in this study. Blood Cd levels may influence cancer risk in men, emphasizing the importance of minimizing Cd exposure to reduce risk. Confirmation of these results in other populations is essential for effective preventive measures against Cd-related cancers.  \nKeywords: cadmium; cancer risk; prospective study  \n1. Introduction  \nCd and its compounds are commonly known to be carcinogenic in humans. The International Agency for Research on Cancer (IARC) has classified Cd and its compounds as Group 1 carcinogens [1,2], based primarily on its association with a higher risk of lung cancer in cohorts of men oc","cbCaiaYOqnfIT4P1","https://ap.wps.com/l/cbCaiaYOqnfIT4P1","pdf",289568,12,"English","# Introduction\n## Background on cadmium carcinogenicity\n## Prior prospective evidence in men\n## Rationale for low-concentration assessment","[{\"question\":\"What does the study evaluate regarding cadmium and cancer risk in men?\",\"answer\":\"It assesses whether blood cadmium (Cd) level serves as a marker for cancer risk in men, especially at lower concentrations where evidence has been limited.\"},{\"question\":\"How was the study designed and how long were participants followed?\",\"answer\":\"A prospective cohort study enrolled 2956 men and followed them for 78 months to measure incident cancer outcomes after blood Cd measurement.\"},{\"question\":\"What were the main results comparing high versus low blood Cd levels?\",\"answer\":\"Men with high blood Cd (\\u003e0.71 µg/L) had a significantly increased cancer risk compared with those with low levels (\\u003c0.19 µg/L), with hazard ratios notably higher in several subgroups.\"}]","Blood Cadmium Level Is a Marker of Cancer Risk in Men | PDF",1789989493]