[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331984-105":59,"doc-detail-331984-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","biomarkers-of-lipid-metabolism-in-gastric-cancer-a-case-control-study","Biomarkers of Lipid Metabolism in Gastric Cancer - A Case Control Study","","The study investigates biomarkers of lipid metabolism and their association with gastric cancer. Case-control data include 1120 gastric cancer patients and 1134 health examiners, with clinic information and serum lipid measures collected: total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). TG and LDL-C are higher in patients, while HDL-C is lower, and HDL-C/LDL-C relate to cancer risk. Lipid changes also show patterns by clinicopathological features and TNM stage.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/biomarkers-of-lipid-metabolism-in-gastric-cancer-a-case-control-study/331984/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/biomarkers-of-lipid-metabolism-in-gastric-cancer-a-case-control-study/331984.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What biomarkers were evaluated for their relationship with gastric cancer risk?","Question",{"text":112,"@type":113},"The study assessed serum TC, TG, LDL-C, and HDL-C, and examined how these lipid measures correlated with gastric cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do lipid levels differ between gastric cancer patients and healthy controls?",{"text":117,"@type":113},"Serum TG and LDL-C were higher in gastric cancer patients, while HDL-C was lower than in the control group.",{"name":119,"@type":110,"acceptedAnswer":120},"How are HDL-C and LDL-C associated with gastric cancer risk and clinicopathological features?",{"text":121,"@type":113},"HDL-C and LDL-C showed significant correlation with gastric cancer risk, and lipid differences were further linked to specific clinicopathological characteristics and TNM stage patterns.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331984,1790165577,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Li etal. BMC Cancer (2024) 24:455  \n[https://doi.org/10.1186/s12885-024-12230-9](https://doi.org/10.1186/s12885-024-12230-9)  \nBMC Cancer  \nRESEARCH Open Access  \nBiomarkers of lipid metabolism in gastric cancer: a case control study  \nFangxuan Li 1*†, Jinli Dou 1†, Lijuan Wei 1, Shixia Li 1 and Juntian Liu 1*  \nAbstract  \nBackground The aim of this study was to explore the correlation between biomarkers of lipid metabolism and gastric cancer.  \nMethods 1120 gastric cancer patients and 1134 health examiners enrolled in this study. The clinic data and serum lipid level, including Total cholesterol (TC), Triglyceride (TG), Low-density lipoprotein cholesterol (LDL-C) and Highdensity lipoprotein cholesterol (HDL-C), were collected.  \nResults Serum TG and LDL-C levels in patients with gastric cancer were higher than those in the control group.  \nHDL-C levels were lower than the control group (P \u003C 0. 05) . HDL-C and LDL-C were significantly correlated with the risk of gastric cancer. Concentrating on clinicopathological features, increased TG was more frequently in male patients with distal gastric cancer, N0 stage and early TNM stage. Increased TC was more frequently in early T, N andTNM stage. Decreased HDL-C was more common in distal location and low-undifferentiated gastric cancer. LDL-C elevation was more common in distal gastric cancer and early T stage.  \nConclusions The serum lipid level of gastric cancer patients was higher than healthy controls. HDL-C and LDL-Cabnormal correlated with gastric cancer risk. However, as the progresses of gastric cancer, poor patient intake, increased tumor consumption, and continuous declining in nutritional status, the level s ofTC and TG gradually decreased in advanced gastric cancer.  \nKeywords Gastric cancer, Lipid metabolism, The risk, Clinicopathologic features, TNM stage  \n†Fangxuan Li and Jinli Dou contributed equally to this work.  \n*Correspondence: Fangxuan Li  \n[lifangxuan2008@126.com](lifangxuan2008@126.com); [lifangxuan@tjmuch.com](lifangxuan@tjmuch.com)  \nJuntian Liu  \n[ljt641024@163.com](ljt641024@163.com)  \n1Department of Cancer Prevention, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China  \nBackground  \nGastric cancer is a common malignant tumor. In the global malignant tumors, the incidence of gastric cancer ranks sixth and the mortality rate ranks the third [1]. It has high incidence in east Asia, especially in China, the incidence and mortality of gastric cancer both rank the second [2]. The common risk factors for gastric cancer include high-salt diet, intake of pickled, smoking, baked and fried food, irregular diet, and Helicobacter pylori (HP) infection [3, 4]. In recent years, with the improvement of people’s living standard, the incidence of abnormal lipid metabolism was significantly increased in China [5]. Dyslipidemia refers to the abnormal metabolism of lipoproteins in the human body, usually manifested as  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/l](http://creativecommons.org/l)icenses/by/4.0/. The Cr","cbCaig9NaTKEBOTW","https://ap.wps.com/l/cbCaig9NaTKEBOTW","pdf",1067363,"English","# Abstract\n# Background\n# Methods and materials\n## Patients\n# Results\n# Conclusions","[{\"question\":\"What biomarkers were evaluated for their relationship with gastric cancer risk?\",\"answer\":\"The study assessed serum TC, TG, LDL-C, and HDL-C, and examined how these lipid measures correlated with gastric cancer.\"},{\"question\":\"How do lipid levels differ between gastric cancer patients and healthy controls?\",\"answer\":\"Serum TG and LDL-C were higher in gastric cancer patients, while HDL-C was lower than in the control group.\"},{\"question\":\"How are HDL-C and LDL-C associated with gastric cancer risk and clinicopathological features?\",\"answer\":\"HDL-C and LDL-C showed significant correlation with gastric cancer risk, and lipid differences were further linked to specific clinicopathological characteristics and TNM stage patterns.\"}]","Biomarkers of Lipid Metabolism in Gastric Cancer - A Case Control Study | PDF",1789996152,18]