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This review summarizes advances in biomolecules and cellular entities for early detection, supported by analyses of CAS Content Collection and Excelra biomarker datasets. It also highlights evolving concepts and development pipelines, with emphasis on pancreatic and liver cancers characterized by difficult early detection and high morbidity and mortality.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/biomarkers-for-early-cancer-detection-a-landscape-view-of-recent-advancements-spotlighting-pancreatic-and-liver-cancers-review/330196/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/biomarkers-for-early-cancer-detection-a-landscape-view-of-recent-advancements-spotlighting-pancreatic-and-liver-cancers-review/330196.png","ImageObject",300,407,{"name":42,"@type":43},"Anda","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-17","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":30},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"Why is early cancer detection critical?","Question",{"text":62,"@type":63},"Early cancer diagnosis saves lives, improves treatment outcomes, reduces suffering, and lowers economic and emotional burdens. It provides a foundation for effective cancer care.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How do cancer biomarkers support early detection and clinical decisions?",{"text":67,"@type":63},"Cancer biomarkers provide varied information from early detection of malignancy to treatment decisions and subsequent monitoring. Biomarkers can be molecular, histologic, radiographic, or physiological entities.",{"name":69,"@type":60,"acceptedAnswer":70},"What makes pancreatic and liver cancers especially challenging?",{"text":71,"@type":63},"They are difficult to detect early and are associated with particularly high morbidity and mortality. The review focuses on how current biomarker knowledge addresses these challenges.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},330196,1792192310,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":30,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},962075006959,"https://ap-avatar.wpscdn.com/avatar/e0002397efbe92a78e?_k=1776741047341049297","This article is licensed under CC-BY 4.0   \n[pubs.acs.org/ptsci](pubs.acs.org/ptsci)  Review   \nBiomarkers for Early Cancer Detection: A Landscape View of Recent Advancements, Spotlighting Pancreatic and Liver Cancers  \nRumiana Tenchov,† Aparna K. Sapra, *,† Janet Sasso, Krittika Ralhan, Anusha Tummala, Norman Azoulay, and Qiongqiong Angela Zhou *  \n Cite This: ACS Pharmacol. Transl. Sci. 2024, 7, 586−613  \nRead Online  \n\n|  |  |  |  |  |  |\n| --- | --- | --- | --- | --- | --- |\n| ACCESS   | Metrics & More |  |  Article Recommendations |  | *sı Supporting Information |\n\nABSTRACT: Cancer is one of the leading causes of death worldwide. Early cancer detection is critical because it can significantly improve treatment outcomes, thus saving lives, reducing suffering, and lessening psychological and economic burdens. Cancer biomarkers provide varied information about cancer, from early detection of malignancy to decisions on treatment and subsequent monitoring. A large variety of molecular, histologic, radiographic, or physiological entities or features are among the common types of cancer biomarkers. Sizeable recent methodological progress and insights have promoted significant developments in the field of early cancer detection biomarkers. Here we provide an overview of recent advances in the knowledge related to biomolecules and cellular entities used for early cancer detection. We examine data from the CAS Content Collection, the largest human-curated collection of published scientific information, as well as from the biomarker datasets at Excelra, and analyze the publication landscape of recent research. We also discuss the evolution of key concepts and cancer biomarkers development pipelines, with a particular focus on pancreatic and liver cancers, which are known to be remarkably difficult to detect  \nearly and to have particularly high morbidity and mortality. The objective of the paper is to provide a broad overview of the evolving landscape of current knowledge on cancer biomarkers and to outline challenges and evaluate growth opportunities, in order to further efforts in solving the problems that remain. The merit of this review stems from the extensive, wide-ranging coverage of the most up-to-date scientific information, allowing unique, unmatched breadth of landscape analysis and in-depth insights. KEYWORDS: biomarker, cancer, diagnosis, prognosis, detection, monitoring, pancreatic cancer, liver cancer  \nC ancer is a leading cause of death worldwide, 1 with  \nincidence of cancer expected to rise as a result of lifestyle deviations and a rapidly aging population.2 The occurrence of cancer increases dramatically with age, most likely due to the accumulation of risks for specific cancers, combined with the tendency for cellular repair mechanisms to become less efficient upon aging.3 Early detection is critical to reducing cancer morbidity and mortality.4,5  \n■ EARLY CANCER DETECTION RATIONALE  \nEarly cancer diagnosis is essential because it can save lives, improve treatment outcomes, reduce suffering, and lessen the economic and emotional burdens associated with cancer. Public awareness, screening programs, and research efforts are critical components of achieving early diagnosis and better cancer care. Specifically, early cancer diagnosis is crucial for certain essential reasons, and it forms the foundation of effective cancer care and  \n6−8 treatment.  \nOne of the primary motivators for early cancer diagnosis is that treatment is often more effective when cancer is detected atan earlier, localized stage. At this stage, the tumor is typically smaller and has not spread to other parts of the body, making it more amenable to curative treatment options such as surgery,  \nradiation therapy, or targeted therapy. Early cancer diagnosis is also associated with higher survival rates. When cancer is identified at an advanced stage, the chances of successful treatment and long-term survival significantly decrease. Early detection ","cbCaipGn7PYhonjF","https://ap.wps.com/l/cbCaipGn7PYhonjF","pdf",4579758,28,"English","# Abstract\n## Early Cancer Detection Rationale\n## Screening and Risk-Based Monitoring\n## Clinical Impact of Early Diagnosis","[{\"question\":\"Why is early cancer detection critical?\",\"answer\":\"Early cancer diagnosis saves lives, improves treatment outcomes, reduces suffering, and lowers economic and emotional burdens. It provides a foundation for effective cancer care.\"},{\"question\":\"How do cancer biomarkers support early detection and clinical decisions?\",\"answer\":\"Cancer biomarkers provide varied information from early detection of malignancy to treatment decisions and subsequent monitoring. Biomarkers can be molecular, histologic, radiographic, or physiological entities.\"},{\"question\":\"What makes pancreatic and liver cancers especially challenging?\",\"answer\":\"They are difficult to detect early and are associated with particularly high morbidity and mortality. The review focuses on how current biomarker knowledge addresses these challenges.\"}]","Biomarkers for Early Cancer Detection: A Landscape View of Recent Advancements, Spotlighting Pancreatic and Liver Cancers - Review | PDF",1789987624,71]