[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-327066-105":59,"doc-detail-327066-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","biomarker-cystatin-b-expression-correlates-with-pathogenesis-in-cervical-cancer","Biomarker cystatin B expression correlates with pathogenesis in cervical cancer","","Cystatin B (CSTB) is evaluated as a biomarker for cervical cancer by linking molecular expression patterns to disease pathogenesis. The study assesses CSTB protein and mRNA levels using immunohistochemical staining on tissue microarrays and quantification by quantitative real-time PCR and western blot in freshly isolated tissues. Bioinformatics identifies CSTB co-expression networks and functional enrichments, and analyzes how elevated CSTB aligns with pathological progression.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/biomarker-cystatin-b-expression-correlates-with-pathogenesis-in-cervical-cancer/327066/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/biomarker-cystatin-b-expression-correlates-with-pathogenesis-in-cervical-cancer/327066.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the objective of the study regarding CSTB?","Question",{"text":112,"@type":113},"To evaluate cystatin B (CSTB) expression as a potential biomarker for cervical cancer and relate it to disease pathogenesis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were CSTB expression levels measured?",{"text":117,"@type":113},"CSTB expression was detected using tissue microarray analysis with immunohistochemical staining, and CSTB mRNA and protein levels were measured by quantitative real-time PCR and western blot, respectively.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find about CSTB and cervical cancer progression?",{"text":121,"@type":113},"High CSTB mRNA and protein expression was observed in cervical cancer tissues, and increased CSTB expression was associated with pathological progress in cervical cancer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},327066,1790875784,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","Biomarker cystatin B expression correlates with pathogenesis in cervical cancer  \nDanjuan Ye 1, Xiaoling Duan 1, Bin Guan2,3, Jia Yuan2,3, Yan Zhu2, Jimin Shi2, Qi Lu 1,2,3 and Guoxiong Xu2,3   \nJournal of International Medical Research 2024, Vol. 52(3) 1–13! The Author(s) 2024 Article reuse guidelines:  \n[sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/03000605241233959](DOI: 10.1177/03000605241233959)[ ](DOI: 10.1177/03000605241233959)[journals.sagepub.com/home/imr](journals.sagepub.com/home/imr)  \nAbstract  \nObjective: Cervical cancer (CC) is one of the most common gynecologic malignancies worldwide. Although rapid improvements have been made regarding its prevention and treatment, little is known about disease pathogenesis and the clinical relevance of reliable biomarkers. The present study evaluated the expression of cystatin B (CSTB) as a potential biomarker of CC. Methods: Tissue microarray analysis and immunohistochemical staining were performed to detect CSTB expression, while CSTB mRNA and protein expression levels of freshly isolated CC tissue were measured by quantitative real-time PCR and western blot, respectively. Bioinformatics were used to analyze the CSTB co-expression network and functional enrichments.  \nResults: We observed high CSTB mRNA and protein expression levels in CC tissues, which was confirmed by tissue microarray in a comparison with paired adjacent non-cancerous cervical tissue samples. CSTB gene enrichments and associations with co-expressed genes were also observed. Further analysis showed that elevated CSTB expression was associated with pathological progress in CC.  \nConclusion: Our data demonstrate that CSTB has the potential to be used as a tissue biomarker with clinical value in patients with CC, which may aid the development of intervention strategies.  \n1 Department of Obstetrics and Gynaecology, Jinshan Hospital, Fudan University, Shanghai, P. R. China 2Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai, P. R. China  \n3Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, P. R. China Corresponding author:  \nGuoxiong Xu, Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai 201508, P. R. China.  \nEmail: [guoxiong.xu@fudan.edu.cn](guoxiong.xu@fudan.edu.cn)  \nCreative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative  \nCommons Attribution-NonCommercial 4.0 License ([https://creativecommons.org/licenses/by-nc/4.0/](https://creativecommons.org/licenses/by-nc/4.0/)) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ([https://us.sagepub.com/en-us/nam/open-access-at-sage](https://us.sagepub.com/en-us/nam/open-access-at-sage)).  \nKeywords  \nCystatin B, lesion, pathological progress, tissue microarray, tumor, cervical cancer  \nDate received: 30 October 2023; accepted: 29 January 2024  \nIntroduction  \nCervical cancer (CC) is one of the most common gynecologic malignancies worldwide, with estimated new cases and deaths in 2020 of 604,000 (about 6.5% of all female cancer incidences) and 342,000 (about 7.7% of all female cancer deaths), respectively.1 Typically, CC shows slow growth, and may not present with any signs or symptoms at an early stage. The main risk factor of CC is a sexually transmitted infection of human papillomavirus (HPV), and persistent infection with highrisk HPV can lead to cervical lesions and invasive cancer.2,3 However, HPV infection alone is not sufficient to cause precancerous lesions or CC. The human immune system usually clears more than 90% of infections within 2 years, and the time between HPV infection and the development of highgrade cervical lesions is usually 10 to 20 years.4,5 Other factors that may increase th","cbCainb77SXKQmIP","https://ap.wps.com/l/cbCainb77SXKQmIP","pdf",1190445,13,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Keywords\n# Introduction","[{\"question\":\"What is the objective of the study regarding CSTB?\",\"answer\":\"To evaluate cystatin B (CSTB) expression as a potential biomarker for cervical cancer and relate it to disease pathogenesis.\"},{\"question\":\"How were CSTB expression levels measured?\",\"answer\":\"CSTB expression was detected using tissue microarray analysis with immunohistochemical staining, and CSTB mRNA and protein levels were measured by quantitative real-time PCR and western blot, respectively.\"},{\"question\":\"What did the study find about CSTB and cervical cancer progression?\",\"answer\":\"High CSTB mRNA and protein expression was observed in cervical cancer tissues, and increased CSTB expression was associated with pathological progress in cervical cancer.\"}]","Biomarker cystatin B expression correlates with pathogenesis in cervical cancer | PDF",1789976168,33]