[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-382737-105":59,"doc-detail-382737-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","biological-implications-of-micrornas-as-regulators-and-biomarkers-of-therapeutic-toxicities-in-breast-cancer","Biological Implications of MicroRNAs as Regulators and Biomarkers of Therapeutic Toxicities in Breast Cancer","","Contemporary breast cancer management combines surgical resection with multimodal systemic treatments including chemotherapy, radiotherapy, endocrine therapy, and targeted agents. Personalized selection based on disease and host factors improves outcomes, yet therapy can induce toxicities that harm long-term quality of life, especially cardiovascular and metabolic complications. MicroRNAs (miRNAs) are small non-coding RNAs that modulate gene expression at a post-transcriptional level and act as regulators, diagnostic markers, and potential therapeutic biomarkers in breast cancer. This review emphasizes miRNAs in predicting treatment-related cardiovascular toxicity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/biological-implications-of-micrornas-as-regulators-and-biomarkers-of-therapeutic-toxicities-in-breast-cancer/382737/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/biological-implications-of-micrornas-as-regulators-and-biomarkers-of-therapeutic-toxicities-in-breast-cancer/382737.png","ImageObject",300,407,{"name":92,"@type":93},"Melati","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main focus of the review on microRNAs in breast cancer?","Question",{"text":112,"@type":113},"The review highlights the role of microRNAs as regulators and biomarkers in breast cancer management, with particular emphasis on predicting treatment-related cardiovascular toxicity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why are treatment-induced toxicities important in breast cancer care?",{"text":117,"@type":113},"Routine treatment strategies can cause toxicities, especially cardiovascular and metabolic side effects, which negatively affect long-term quality of life metrics.",{"name":119,"@type":110,"acceptedAnswer":120},"How do microRNAs influence gene expression relevant to breast cancer?",{"text":121,"@type":113},"MicroRNAs are small non-coding RNAs that modulate genetic expression at a post-transcriptional cellular level, influencing protein synthesis and disease-related processes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},382737,1790370553,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962085570644,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Review  \nBiological Implications of MicroRNAs as Regulators and Biomarkers of Therapeutic Toxicities in Breast Cancer  \nRaza Abbas Syed *, Matthew G. Davey , Vinitha Richard, Nicola Miller  and Michael J. Kerin  \nCitation: Abbas Syed, R.; Davey, M.G.; Richard, V.; Miller, N.; Kerin, M.J. Biological Implications of MicroRNAs as Regulators and Biomarkers of Therapeutic Toxicities in Breast Cancer. Int. J. Mol. Sci. 2023, 24, 12694. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms241612694  \nAcademic Editor: Fabio Puglisi  \nReceived: 16 July 2023  \nRevised: 29 July 2023  \nAccepted: 7 August 2023  \nPublished: 11 August 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nDiscipline of Surgery, Lambe Institute for Translational Research, University of Galway, H91 YR71 Galway, Ireland; [mattgdavey1@gmail.com](mattgdavey1@gmail.com) (M.G.D.)  \n* Correspondence: [ray.abbas@outlook.ie](ray.abbas@outlook.ie); Tel.: +35-391-524-411  \nAbstract: Contemporary breast cancer management includes surgical resection combined with a multimodal approach, including chemotherapy, radiotherapy, endocrine therapy, and targeted therapies. Breast cancer treatment is now personalised in accordance with disease and host factors, which has translated to enhanced outcomes for the vast majority of patients. Unfortunately, the treatment of the disease involves patients developing treatment-induced toxicities, with cardiovascular and metabolic side effects having negative implications for long-term quality-of-life metrics. MicroRNAs (miRNAs) are a class of small non-coding ribonucleic acids that are 17 to 25 nucleotides in length, which have utility in modifying genetic expression by working at a post-transcriptional cellular level. miRNAshave involvement in modulating breast cancer development, which is well described, with these biomarkers acting as important regulators of disease, as well as potential diagnostic and therapeutic biomarkers. This review focuses on highlighting the role of miRNAs as regulators and biomarkers of disease, particularly in breast cancer management, with a specific mention of the potential value of miRNAs in predicting treatment-related cardiovascular toxicity.  \nKeywords: microRNA; breast cancer; diabetes; cardiovascular disease; miRNA profiling; posttranscriptomic profiling  \n1. Introduction  \nOne in eight women worldwide will be diagnosed with breast cancer [1], with the disease representing the most common cause of cancer-related death in women [2] . Therefore, it is imperative that further translational research efforts focus on adding novel diagnostic and therapeutic tools to the clinician's armamentarium. Breast cancer is typically classified into four intrinsic subtypes, including Luminal A, Luminal B, Erb-B2 overexpressing, and“basal-like” [3] . The type of cancer diagnosed has implications in treatment selection, as well as predicting disease recurrence. Improvements in our understanding of the molecular intricacies of the disease [4], coupled with the advent of targeted therapeutics [5], have facilitated enhanced oncological and survival outcomes for the vast majority (5-year survival increasing from 62.5% in the 1970s to 86.2% in 2007, as evident from data from the Surveillance, Epidemiology and End Results (SEER) database [6]) . Contemporary breast cancer treatment now includes a multimodal approach, where surgical resection is coupled with radiotherapy, chemotherapy, and endocrine agents, as well as targeted therapies (including immunomodulatory drugs) [7,8] . Moreover, surgical strategy has become more conservative in recent decades, as evidenced by Fisher et al., who previous","cbCaic3tsnlF0TZ4","https://ap.wps.com/l/cbCaic3tsnlF0TZ4","pdf",338499,13,"English","# 1. Introduction\n## Breast cancer subtypes and treatment approaches\n## Treatment-induced toxicities and cardiovascular risk\n## MicroRNAs as regulators and biomarkers","[{\"question\":\"What is the main focus of the review on microRNAs in breast cancer?\",\"answer\":\"The review highlights the role of microRNAs as regulators and biomarkers in breast cancer management, with particular emphasis on predicting treatment-related cardiovascular toxicity.\"},{\"question\":\"Why are treatment-induced toxicities important in breast cancer care?\",\"answer\":\"Routine treatment strategies can cause toxicities, especially cardiovascular and metabolic side effects, which negatively affect long-term quality of life metrics.\"},{\"question\":\"How do microRNAs influence gene expression relevant to breast cancer?\",\"answer\":\"MicroRNAs are small non-coding RNAs that modulate genetic expression at a post-transcriptional cellular level, influencing protein synthesis and disease-related processes.\"}]","Biological Implications of MicroRNAs as Regulators and Biomarkers of Therapeutic Toxicities in Breast Cancer | PDF",1790252127,33]